NPDC1_HUMAN
ID NPDC1_HUMAN Reviewed; 325 AA.
AC Q9NQX5; Q5SPY8; Q9BTD6; Q9BXT3; Q9NQS2; Q9Y434;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-2002, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Neural proliferation differentiation and control protein 1;
DE Short=NPDC-1;
DE Flags: Precursor;
GN Name=NPDC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Iris;
RA Wistow G.J.;
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal liver;
RX PubMed=11245976; DOI=10.1016/s0378-1119(01)00324-9;
RA Qu X., Zhang C., Zhai Y., Xing G., Wei H., Yu Y., Wu S., He F.;
RT "Characterization and tissue expression of a novel human gene npdc1.";
RL Gene 264:37-44(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 39-325.
RC TISSUE=Brain;
RA Evrard C., Apiou F., Dutrillaux B., Rouget P.;
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 218-325.
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Suppresses oncogenic transformation in neural and non-neural
CC cells and down-regulates neural cell proliferation. Might be involved
CC in transcriptional regulation (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q9NQX5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-748927, EBI-3867333;
CC Q9NQX5; P50402: EMD; NbExp=3; IntAct=EBI-748927, EBI-489887;
CC Q9NQX5; Q5TD97: FHL5; NbExp=5; IntAct=EBI-748927, EBI-750641;
CC Q9NQX5; P61978-2: HNRNPK; NbExp=5; IntAct=EBI-748927, EBI-7060731;
CC Q9NQX5; Q5VWX1: KHDRBS2; NbExp=6; IntAct=EBI-748927, EBI-742808;
CC Q9NQX5; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-748927, EBI-11959885;
CC Q9NQX5; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-748927, EBI-11749135;
CC Q9NQX5; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-748927, EBI-10172150;
CC Q9NQX5; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-748927, EBI-12012928;
CC Q9NQX5; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-748927, EBI-10172290;
CC Q9NQX5; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-748927, EBI-10171774;
CC Q9NQX5; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-748927, EBI-10172052;
CC Q9NQX5; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-748927, EBI-10176379;
CC Q9NQX5; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-748927, EBI-11953334;
CC Q9NQX5; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-748927, EBI-14065470;
CC Q9NQX5; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-748927, EBI-11957260;
CC Q9NQX5; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-748927, EBI-11958132;
CC Q9NQX5; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-748927, EBI-3958099;
CC Q9NQX5; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-748927, EBI-1043191;
CC Q9NQX5; P21145: MAL; NbExp=3; IntAct=EBI-748927, EBI-3932027;
CC Q9NQX5; Q99750: MDFI; NbExp=8; IntAct=EBI-748927, EBI-724076;
CC Q9NQX5; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-748927, EBI-12070086;
CC Q9NQX5; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-748927, EBI-945833;
CC Q9NQX5; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-748927, EBI-22310682;
CC Q9NQX5; Q9UKJ1: PILRA; NbExp=6; IntAct=EBI-748927, EBI-965833;
CC Q9NQX5; Q15415: RBMY1J; NbExp=3; IntAct=EBI-748927, EBI-8642021;
CC Q9NQX5; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-748927, EBI-10243654;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in adult brain; especially in
CC hippocampus, frontal lobe and temporal lobe.
CC -!- SIMILARITY: Belongs to the NPDC1/cab-1 family. {ECO:0000305}.
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DR EMBL; AF272357; AAF76225.1; -; mRNA.
DR EMBL; AF285836; AAK27328.1; -; mRNA.
DR EMBL; AL807752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC004217; AAH04217.1; -; mRNA.
DR EMBL; AF283247; AAF82603.1; -; mRNA.
DR EMBL; AL050221; CAB43321.1; -; mRNA.
DR CCDS; CCDS7024.1; -.
DR PIR; T08809; T08809.
DR RefSeq; NP_056207.3; NM_015392.3.
DR AlphaFoldDB; Q9NQX5; -.
DR BioGRID; 121167; 66.
DR IntAct; Q9NQX5; 38.
DR STRING; 9606.ENSP00000360660; -.
DR GlyGen; Q9NQX5; 2 sites, 1 O-linked glycan (2 sites).
DR iPTMnet; Q9NQX5; -.
DR PhosphoSitePlus; Q9NQX5; -.
DR BioMuta; NPDC1; -.
DR DMDM; 22261810; -.
DR EPD; Q9NQX5; -.
DR jPOST; Q9NQX5; -.
DR MassIVE; Q9NQX5; -.
DR MaxQB; Q9NQX5; -.
DR PaxDb; Q9NQX5; -.
DR PeptideAtlas; Q9NQX5; -.
DR PRIDE; Q9NQX5; -.
DR ProteomicsDB; 82224; -.
DR Antibodypedia; 2177; 127 antibodies from 24 providers.
DR DNASU; 56654; -.
DR Ensembl; ENST00000371601.5; ENSP00000360660.4; ENSG00000107281.10.
DR GeneID; 56654; -.
DR KEGG; hsa:56654; -.
DR MANE-Select; ENST00000371601.5; ENSP00000360660.4; NM_015392.4; NP_056207.3.
DR UCSC; uc004ckt.3; human.
DR CTD; 56654; -.
DR DisGeNET; 56654; -.
DR GeneCards; NPDC1; -.
DR HGNC; HGNC:7899; NPDC1.
DR HPA; ENSG00000107281; Low tissue specificity.
DR MIM; 605798; gene.
DR neXtProt; NX_Q9NQX5; -.
DR OpenTargets; ENSG00000107281; -.
DR PharmGKB; PA31701; -.
DR VEuPathDB; HostDB:ENSG00000107281; -.
DR eggNOG; KOG3884; Eukaryota.
DR GeneTree; ENSGT00440000038604; -.
DR HOGENOM; CLU_058246_0_1_1; -.
DR InParanoid; Q9NQX5; -.
DR OMA; NDHVFIV; -.
DR OrthoDB; 924213at2759; -.
DR PhylomeDB; Q9NQX5; -.
DR TreeFam; TF318443; -.
DR PathwayCommons; Q9NQX5; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR SignaLink; Q9NQX5; -.
DR BioGRID-ORCS; 56654; 14 hits in 1064 CRISPR screens.
DR ChiTaRS; NPDC1; human.
DR GeneWiki; NPDC1; -.
DR GenomeRNAi; 56654; -.
DR Pharos; Q9NQX5; Tbio.
DR PRO; PR:Q9NQX5; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9NQX5; protein.
DR Bgee; ENSG00000107281; Expressed in right hemisphere of cerebellum and 97 other tissues.
DR ExpressionAtlas; Q9NQX5; baseline and differential.
DR Genevisible; Q9NQX5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR InterPro; IPR009635; NPDC1.
DR PANTHER; PTHR23352; PTHR23352; 1.
DR Pfam; PF06809; NPDC1; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..325
FT /note="Neural proliferation differentiation and control
FT protein 1"
FT /id="PRO_0000021830"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 138..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 229
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CONFLICT 113
FT /note="H -> Q (in Ref. 1; AAF76225)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="L -> M (in Ref. 2; AAK27328)"
FT /evidence="ECO:0000305"
FT CONFLICT 210
FT /note="Q -> H (in Ref. 2; AAK27328)"
FT /evidence="ECO:0000305"
FT CONFLICT 218..226
FT /note="KADYATAKA -> EGRLRHCEG (in Ref. 6; CAB43321)"
FT /evidence="ECO:0000305"
FT CONFLICT 289
FT /note="E -> D (in Ref. 5; AAF82603)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 325 AA; 34516 MW; 21D6512AD345A575 CRC64;
MATPLPPPSP RHLRLLRLLL SGLVLGAALR GAAAGHPDVA ACPGSLDCAL KRRARCPPGA
HACGPCLQPF QEDQQGLCVP RMRRPPGGGR PQPRLEDEID FLAQELARKE SGHSTPPLPK
DRQRLPEPAT LGFSARGQGL ELGLPSTPGT PTPTPHTSLG SPVSSDPVHM SPLEPRGGQG
DGLALVLILA FCVAGAAALS VASLCWCRLQ REIRLTQKAD YATAKAPGSP AAPRISPGDQ
RLAQSAEMYH YQHQRQQMLC LERHKEPPKE LDTASSDEEN EDGDFTVYEC PGLAPTGEME
VRNPLFDHAA LSAPLPAPSS PPALP
