NPDC1_MOUSE
ID NPDC1_MOUSE Reviewed; 332 AA.
AC Q64322; Q99J69;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Neural proliferation differentiation and control protein 1;
DE Short=NPDC-1;
DE Flags: Precursor;
GN Name=Npdc1; Synonyms=Npdc-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=7903403; DOI=10.1002/jnr.490360204;
RA Galiana E., Bernard R., Borde I., Rouget P., Evrard C.;
RT "Proliferation and differentiation properties of bipotent glial progenitor
RT cell lines immortalized with the adenovirus E1A gene.";
RL J. Neurosci. Res. 36:133-146(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=7878019; DOI=10.1073/pnas.92.5.1560;
RA Galiana E., Vernier P., Dupont E., Evrard C., Rouget P.;
RT "Identification of a neural-specific cDNA, NPDC-1, able to down-regulate
RT cell proliferation and to suppress transformation.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:1560-1564(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Suppresses oncogenic transformation in neural and non-neural
CC cells and down-regulates neural cell proliferation. Might be involved
CC in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the brain and nervous system. Not
CC detected in liver, heart, skeletal muscle, spleen, pancreas, pituitary
CC and adrenal glands. Expression increases when cultured neural cells are
CC growth-arrested and begin to differentiate.
CC -!- SIMILARITY: Belongs to the NPDC1/cab-1 family. {ECO:0000305}.
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DR EMBL; X67209; CAA47648.1; -; mRNA.
DR EMBL; L03814; AAA39836.1; -; mRNA.
DR EMBL; AK146466; BAE27193.1; -; mRNA.
DR EMBL; AL732557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466542; EDL08243.1; -; Genomic_DNA.
DR EMBL; BC003320; AAH03320.1; -; mRNA.
DR CCDS; CCDS15771.1; -.
DR PIR; I48691; I48691.
DR RefSeq; NP_032747.2; NM_008721.4.
DR AlphaFoldDB; Q64322; -.
DR STRING; 10090.ENSMUSP00000071387; -.
DR iPTMnet; Q64322; -.
DR PhosphoSitePlus; Q64322; -.
DR MaxQB; Q64322; -.
DR PaxDb; Q64322; -.
DR PRIDE; Q64322; -.
DR ProteomicsDB; 293682; -.
DR Antibodypedia; 2177; 127 antibodies from 24 providers.
DR DNASU; 18146; -.
DR Ensembl; ENSMUST00000071442; ENSMUSP00000071387; ENSMUSG00000015094.
DR GeneID; 18146; -.
DR KEGG; mmu:18146; -.
DR UCSC; uc008irx.2; mouse.
DR CTD; 56654; -.
DR MGI; MGI:1099802; Npdc1.
DR VEuPathDB; HostDB:ENSMUSG00000015094; -.
DR eggNOG; KOG3884; Eukaryota.
DR GeneTree; ENSGT00440000038604; -.
DR HOGENOM; CLU_058246_0_1_1; -.
DR InParanoid; Q64322; -.
DR OrthoDB; 924213at2759; -.
DR TreeFam; TF318443; -.
DR Reactome; R-MMU-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR BioGRID-ORCS; 18146; 2 hits in 60 CRISPR screens.
DR ChiTaRS; Npdc1; mouse.
DR PRO; PR:Q64322; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q64322; protein.
DR Bgee; ENSMUSG00000015094; Expressed in cortical plate and 243 other tissues.
DR ExpressionAtlas; Q64322; baseline and differential.
DR Genevisible; Q64322; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR009635; NPDC1.
DR PANTHER; PTHR23352; PTHR23352; 1.
DR Pfam; PF06809; NPDC1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..332
FT /note="Neural proliferation differentiation and control
FT protein 1"
FT /id="PRO_0000021831"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 145..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 272..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 236
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NQX5"
FT CONFLICT 126
FT /note="A -> R (in Ref. 1; CAA47648 and 2; AAA39836)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 332 AA; 35720 MW; 22BDD66E8392B171 CRC64;
MATPVPPPSP RHLRLLRLLL SGLILGAALN GATARRPDAT TCPGSLDCAL KRRAKCPPGA
HACGPCLQSF QEDQRGFCVP RKHLSSGEGL PQPRLEEEID SLAQELALKE KEAGHSRLTA
QPLLEAAQKL LEPAATLGFS QWGQRLEPGL PSTHGTSSPI PHTSLSSRAS SGPVQMSPLE
PQGRHGNGLT LVLILAFCLA SSAALAVAAL CWCRLQREIR LTQKADYAAT AKGPTSPSTP
RISPGDQRLA HSAEMYHYQH QRQQMLCLER HKEPPKELES ASSDEENEDG DFTVYECPGL
APTGEMEVRN PLFDHSTLSA PVPGPHSLPP LQ
