ID   NPF1_LEPDE              Reviewed;          10 AA.
AC   Q9TWD6;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   02-JUN-2021, entry version 31.
DE   RecName: Full=Neuropeptide NPF-1;
DE            Short=Led-NPF-1;
DE   AltName: Full=Short neuropeptide F I;
OS   Leptinotarsa decemlineata (Colorado potato beetle) (Doryphora
OS   decemlineata).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia;
OC   Chrysomeloidea; Chrysomelidae; Chrysomelinae; Doryphorini; Leptinotarsa.
OX   NCBI_TaxID=7539;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND AMIDATION AT PHE-10.
RC   TISSUE=Cerebral ganglion {ECO:0000269|PubMed:8814784};
RX   PubMed=8814784; DOI=10.1016/0965-1748(95)00104-2;
RA   Spittaels K., Verhaert P., Shaw C., Johnston R.N., Devreese B.,
RA   Van Beeumen J., De Loof A.;
RT   "Insect neuropeptide F (NPF)-related peptides: isolation from Colorado
RT   potato beetle (Leptinotarsa decemlineata) brain.";
RL   Insect Biochem. Mol. Biol. 26:375-382(1996).
RN   [2] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=10098622; DOI=10.1016/s0196-9781(98)00152-1;
RA   Cerstiaens A., Benfekih L., Zouiten H., Verhaert P., De Loof A.,
RA   Schoofs L.;
RT   "Led-NPF-1 stimulates ovarian development in locusts.";
RL   Peptides 20:39-44(1999).
RN   [3] {ECO:0000305}
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=15081426; DOI=10.1016/j.bbrc.2004.03.136;
RA   Huybrechts J., De Loof A., Schoofs L.;
RT   "Diapausing Colorado potato beetles are devoid of short neuropeptide F I
RT   and II.";
RL   Biochem. Biophys. Res. Commun. 317:909-916(2004).
CC   -!- FUNCTION: Neuropeptide. Stimulates egg development in L.migratoria, but
CC       not in N.bullata. May be involved in the regulation of adult diapause.
CC       {ECO:0000269|PubMed:10098622, ECO:0000269|PubMed:15081426}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9VIQ0}.
CC   -!- DEVELOPMENTAL STAGE: Found in the brain of non-diapausing beetles, but
CC       not in diapausing beetles. {ECO:0000269|PubMed:15081426}.
CC   -!- MASS SPECTROMETRY: Mass=1212.8; Method=MALDI; Note=Using a Fisons mass
CC       spectrometer.; Evidence={ECO:0000269|PubMed:8814784};
CC   -!- MASS SPECTROMETRY: Mass=1212.3; Method=MALDI; Note=Using a Bruker mass
CC       spectrometer.; Evidence={ECO:0000269|PubMed:8814784};
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000255}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Hormone; Neuropeptide; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Neuropeptide NPF-1"
FT                   /evidence="ECO:0000269|PubMed:8814784"
FT                   /id="PRO_0000328937"
FT   MOD_RES         10
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:8814784"
SQ   SEQUENCE   10 AA;  1213 MW;  351E02340736C768 CRC64;
     ARGPQLRLRF