ID   NPFF_BOVIN              Reviewed;         115 AA.
AC   Q9TUX7;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Pro-FMRFamide-related neuropeptide FF;
DE   AltName: Full=FMRFamide-related peptides;
DE   Contains:
DE     RecName: Full=Neuropeptide SF;
DE              Short=NPSF;
DE   Contains:
DE     RecName: Full=Neuropeptide FF;
DE              Short=NPFF;
DE   Contains:
DE     RecName: Full=Neuropeptide AF;
DE              Short=NPAF;
DE   Flags: Precursor;
GN   Name=NPFF;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=10220558;
RA   Vilim F.S., Aarnisalo A.A., Nieminen M.L., Lintunen M., Karlstedt K.,
RA   Kontinen V.K., Kalso E., States B., Panula P., Ziff E.;
RT   "Gene for pain modulatory neuropeptide NPFF: induction in spinal cord by
RT   noxious stimuli.";
RL   Mol. Pharmacol. 55:804-811(1999).
CC   -!- FUNCTION: Morphine modulating peptides. Have wide-ranging physiologic
CC       effects, including the modulation of morphine-induced analgesia,
CC       elevation of arterial blood pressure, and increased somatostatin
CC       secretion from the pancreas. The neuropeptide FF potentiates and
CC       sensitizes ASIC3 cation channel.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000305}.
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DR   EMBL; AF148699; AAD39827.1; -; mRNA.
DR   RefSeq; NP_776548.1; NM_174123.3.
DR   AlphaFoldDB; Q9TUX7; -.
DR   STRING; 9913.ENSBTAP00000003109; -.
DR   PaxDb; Q9TUX7; -.
DR   Ensembl; ENSBTAT00000003109; ENSBTAP00000003109; ENSBTAG00000002401.
DR   GeneID; 281354; -.
DR   KEGG; bta:281354; -.
DR   CTD; 8620; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002401; -.
DR   VGNC; VGNC:32198; NPFF.
DR   eggNOG; ENOG502S60B; Eukaryota.
DR   GeneTree; ENSGT00390000015021; -.
DR   HOGENOM; CLU_169782_0_0_1; -.
DR   InParanoid; Q9TUX7; -.
DR   OMA; GEFWSLA; -.
DR   OrthoDB; 1435009at2759; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000002401; Expressed in temporal cortex and 55 other tissues.
DR   GO; GO:0043679; C:axon terminus; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0043204; C:perikaryon; IBA:GO_Central.
DR   GO; GO:0098794; C:postsynapse; IEA:GOC.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IBA:GO_Central.
DR   GO; GO:0060079; P:excitatory postsynaptic potential; IBA:GO_Central.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR008065; NPFF.
DR   PANTHER; PTHR15044; PTHR15044; 1.
DR   Pfam; PF15085; NPFF; 1.
DR   PIRSF; PIRSF038092; FMRFamid-rel_pep_precur; 1.
DR   PRINTS; PR01682; FMRFAMIDEPEP.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..66
FT                   /id="PRO_0000009893"
FT   PEPTIDE         68..78
FT                   /note="Neuropeptide SF"
FT                   /id="PRO_0000009894"
FT   PEPTIDE         71..78
FT                   /note="Neuropeptide FF"
FT                   /id="PRO_0000009895"
FT   PROPEP          81..94
FT                   /id="PRO_0000009896"
FT   PEPTIDE         95..112
FT                   /note="Neuropeptide AF"
FT                   /id="PRO_0000009897"
FT   REGION          20..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          78..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         78
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         112
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   115 AA;  12614 MW;  B40D9F53FF4AF127 CRC64;
     MDARQAAALL LVLLLVTDWS HAEGPGGRDG GDQIFMEEDS GAHPAQDAQT PRSLLRSLLQ
     AMQRPGRSPA FLFQPQRFGR NTRGSWSNKR LSPRAGEGLS SPFWSLAAPQ RFGKK