NPFF_MOUSE
ID NPFF_MOUSE Reviewed; 114 AA.
AC Q9WVA8;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Pro-FMRFamide-related neuropeptide FF;
DE AltName: Full=FMRFamide-related peptides;
DE Contains:
DE RecName: Full=Neuropeptide SF;
DE Short=NPSF;
DE Contains:
DE RecName: Full=Neuropeptide FF;
DE Short=NPFF;
DE Contains:
DE RecName: Full=Neuropeptide AF-like;
DE Short=NPAF;
DE Flags: Precursor;
GN Name=Npff;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=10220558;
RA Vilim F.S., Aarnisalo A.A., Nieminen M.L., Lintunen M., Karlstedt K.,
RA Kontinen V.K., Kalso E., States B., Panula P., Ziff E.;
RT "Gene for pain modulatory neuropeptide NPFF: induction in spinal cord by
RT noxious stimuli.";
RL Mol. Pharmacol. 55:804-811(1999).
RN [2]
RP FUNCTION.
RX PubMed=10798398; DOI=10.1016/s0896-6273(00)81144-7;
RA Askwith C.C., Cheng C., Ikuma M., Benson C., Price M.P., Welsh M.J.;
RT "Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory
RT neurons and proton-gated DEG/ENaC channels.";
RL Neuron 26:133-141(2000).
CC -!- FUNCTION: Morphine modulating peptides. Have wide-ranging physiologic
CC effects, including the modulation of morphine-induced analgesia,
CC elevation of arterial blood pressure, and increased somatostatin
CC secretion from the pancreas. Neuropeptide FF potentiates and sensitizes
CC ASIC1 and ASIC3 channels. {ECO:0000269|PubMed:10798398}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000305}.
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DR EMBL; AF148701; AAD39829.1; -; mRNA.
DR CCDS; CCDS27887.1; -.
DR RefSeq; NP_061257.1; NM_018787.1.
DR AlphaFoldDB; Q9WVA8; -.
DR STRING; 10090.ENSMUSP00000023814; -.
DR PaxDb; Q9WVA8; -.
DR PRIDE; Q9WVA8; -.
DR ProteomicsDB; 293950; -.
DR Antibodypedia; 15271; 138 antibodies from 23 providers.
DR DNASU; 54615; -.
DR Ensembl; ENSMUST00000023814; ENSMUSP00000023814; ENSMUSG00000023052.
DR GeneID; 54615; -.
DR KEGG; mmu:54615; -.
DR UCSC; uc007xwj.1; mouse.
DR CTD; 8620; -.
DR MGI; MGI:1891708; Npff.
DR VEuPathDB; HostDB:ENSMUSG00000023052; -.
DR eggNOG; ENOG502S60B; Eukaryota.
DR GeneTree; ENSGT00390000015021; -.
DR HOGENOM; CLU_169782_0_0_1; -.
DR InParanoid; Q9WVA8; -.
DR OMA; GEFWSLA; -.
DR OrthoDB; 1435009at2759; -.
DR PhylomeDB; Q9WVA8; -.
DR TreeFam; TF330924; -.
DR Reactome; R-MMU-389397; Orexin and neuropeptides FF and QRFP bind to their respective receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 54615; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Npff; mouse.
DR PRO; PR:Q9WVA8; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9WVA8; protein.
DR Bgee; ENSMUSG00000023052; Expressed in bone marrow and 63 other tissues.
DR Genevisible; Q9WVA8; MM.
DR GO; GO:0043679; C:axon terminus; ISO:MGI.
DR GO; GO:0030425; C:dendrite; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0043204; C:perikaryon; ISO:MGI.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:0031982; C:vesicle; ISO:MGI.
DR GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISO:MGI.
DR GO; GO:0060079; P:excitatory postsynaptic potential; ISO:MGI.
DR GO; GO:0032099; P:negative regulation of appetite; ISO:MGI.
DR GO; GO:0010459; P:negative regulation of heart rate; ISO:MGI.
DR GO; GO:0046676; P:negative regulation of insulin secretion; ISO:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISO:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0003254; P:regulation of membrane depolarization; ISO:MGI.
DR GO; GO:0051930; P:regulation of sensory perception of pain; ISO:MGI.
DR GO; GO:0070253; P:somatostatin secretion; ISO:MGI.
DR GO; GO:0030103; P:vasopressin secretion; ISO:MGI.
DR InterPro; IPR008065; NPFF.
DR PANTHER; PTHR15044; PTHR15044; 1.
DR Pfam; PF15085; NPFF; 1.
DR PIRSF; PIRSF038092; FMRFamid-rel_pep_precur; 1.
DR PRINTS; PR01682; FMRFAMIDEPEP.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..69
FT /id="PRO_0000009903"
FT PEPTIDE 72..82
FT /note="Neuropeptide SF"
FT /id="PRO_0000009904"
FT PEPTIDE 75..82
FT /note="Neuropeptide FF"
FT /id="PRO_0000009905"
FT PROPEP 85..100
FT /id="PRO_0000009906"
FT PEPTIDE 101..111
FT /note="Neuropeptide AF-like"
FT /id="PRO_0000009907"
FT MOD_RES 82
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT MOD_RES 111
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 114 AA; 13012 MW; 8743308C46561DDA CRC64;
MDSKWAALLL LLLLLLNWGH TEEAGSWGED QVFAGEDKGP HPPQYAHIPD RIQTPGSLFR
VLLQAMDTPR RSPAFLFQPQ RFGRSAWGSW SKEQLNPQAR QFWSLAAPQR FGKK
