NPFF_RAT
ID NPFF_RAT Reviewed; 114 AA.
AC Q9WVA9;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Pro-FMRFamide-related neuropeptide FF;
DE AltName: Full=FMRFamide-related peptides;
DE Contains:
DE RecName: Full=Neuropeptide SF;
DE Short=NPSF;
DE Contains:
DE RecName: Full=Neuropeptide FF;
DE Short=NPFF;
DE Contains:
DE RecName: Full=Neuropeptide AF-like;
DE Short=NPAF;
DE Flags: Precursor;
GN Name=Npff;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=10220558;
RA Vilim F.S., Aarnisalo A.A., Nieminen M.L., Lintunen M., Karlstedt K.,
RA Kontinen V.K., Kalso E., States B., Panula P., Ziff E.;
RT "Gene for pain modulatory neuropeptide NPFF: induction in spinal cord by
RT noxious stimuli.";
RL Mol. Pharmacol. 55:804-811(1999).
RN [2]
RP FUNCTION.
RX PubMed=11587714; DOI=10.1016/s0028-3908(01)00107-1;
RA Catarsi S., Babinski K., Seguela P.;
RT "Selective modulation of heteromeric ASIC proton-gated channels by
RT neuropeptide FF.";
RL Neuropharmacology 41:592-600(2001).
RN [3]
RP FUNCTION.
RX PubMed=12668052; DOI=10.1016/s0028-3908(03)00047-9;
RA Deval E., Baron A., Lingueglia E., Mazarguil H., Zajac J.-M., Lazdunski M.;
RT "Effects of neuropeptide SF and related peptides on acid sensing ion
RT channel 3 and sensory neuron excitability.";
RL Neuropharmacology 44:662-671(2003).
CC -!- FUNCTION: Morphine modulating peptides. Have wide-ranging physiologic
CC effects, including the modulation of morphine-induced analgesia,
CC elevation of arterial blood pressure, and increased somatostatin
CC secretion from the pancreas. Neuropeptide FF and SF potentiate and
CC sensitize ASIC2 and ASIC3 channels. {ECO:0000269|PubMed:11587714,
CC ECO:0000269|PubMed:12668052}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC {ECO:0000305}.
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DR EMBL; AF148700; AAD39828.1; -; mRNA.
DR RefSeq; NP_072108.1; NM_022586.1.
DR AlphaFoldDB; Q9WVA9; -.
DR STRING; 10116.ENSRNOP00000065607; -.
DR BindingDB; Q9WVA9; -.
DR PaxDb; Q9WVA9; -.
DR PRIDE; Q9WVA9; -.
DR GeneID; 60337; -.
DR KEGG; rno:60337; -.
DR CTD; 8620; -.
DR RGD; 62033; Npff.
DR eggNOG; ENOG502S60B; Eukaryota.
DR HOGENOM; CLU_169782_0_0_1; -.
DR InParanoid; Q9WVA9; -.
DR OMA; GEFWSLA; -.
DR OrthoDB; 1435009at2759; -.
DR PhylomeDB; Q9WVA9; -.
DR Reactome; R-RNO-389397; Orexin and neuropeptides FF and QRFP bind to their respective receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:Q9WVA9; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000047739; Expressed in lung and 19 other tissues.
DR Genevisible; Q9WVA9; RN.
DR GO; GO:0043679; C:axon terminus; IDA:RGD.
DR GO; GO:0030425; C:dendrite; IDA:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:RGD.
DR GO; GO:0043204; C:perikaryon; IDA:RGD.
DR GO; GO:0098794; C:postsynapse; IEA:GOC.
DR GO; GO:0031982; C:vesicle; IDA:RGD.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IDA:RGD.
DR GO; GO:0005184; F:neuropeptide hormone activity; IDA:RGD.
DR GO; GO:0002438; P:acute inflammatory response to antigenic stimulus; IEP:RGD.
DR GO; GO:0060079; P:excitatory postsynaptic potential; IDA:RGD.
DR GO; GO:0060135; P:maternal process involved in female pregnancy; IEP:RGD.
DR GO; GO:0032099; P:negative regulation of appetite; IDA:RGD.
DR GO; GO:0010459; P:negative regulation of heart rate; IDA:RGD.
DR GO; GO:0046676; P:negative regulation of insulin secretion; IDA:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045777; P:positive regulation of blood pressure; IDA:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
DR GO; GO:0003254; P:regulation of membrane depolarization; IDA:RGD.
DR GO; GO:0051930; P:regulation of sensory perception of pain; IDA:RGD.
DR GO; GO:0043278; P:response to morphine; IEP:RGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR GO; GO:0070253; P:somatostatin secretion; IDA:RGD.
DR GO; GO:0021510; P:spinal cord development; IEP:RGD.
DR GO; GO:0030103; P:vasopressin secretion; IDA:RGD.
DR InterPro; IPR008065; NPFF.
DR PANTHER; PTHR15044; PTHR15044; 1.
DR Pfam; PF15085; NPFF; 1.
DR PIRSF; PIRSF038092; FMRFamid-rel_pep_precur; 1.
DR PRINTS; PR01682; FMRFAMIDEPEP.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..69
FT /id="PRO_0000009908"
FT PEPTIDE 72..82
FT /note="Neuropeptide SF"
FT /id="PRO_0000009909"
FT PEPTIDE 75..82
FT /note="Neuropeptide FF"
FT /id="PRO_0000009910"
FT PROPEP 85..100
FT /id="PRO_0000009911"
FT PEPTIDE 101..111
FT /note="Neuropeptide AF-like"
FT /id="PRO_0000009912"
FT REGION 29..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 82
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
FT MOD_RES 111
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 114 AA; 13152 MW; 482ABA87BA28F9E4 CRC64;
MDSKWAAVLL LLLLLRNWGH AEEAGSWGED QVFAEEDKGP HPSQYAHTPD RIQTPGSLMR
VLLQAMERPR RNPAFLFQPQ RFGRNAWGPW SKEQLSPQAR EFWSLAAPQR FGKK
