ID   NPF_AEDAE               Reviewed;          90 AA.
AC   Q8MP00; Q17HA5;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Neuropeptide F;
DE            Short=AeaNPF;
DE            Short=NPF;
DE   Flags: Precursor;
GN   Name=npf; ORFNames=AAEL002733;
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAM74026.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 33-62, TISSUE SPECIFICITY,
RP   AND AMIDATION AT PHE-63.
RC   TISSUE=Head {ECO:0000269|PubMed:12182937}, and
RC   Midgut {ECO:0000269|PubMed:12182937};
RX   PubMed=12182937; DOI=10.1016/s0196-9781(02)00074-8;
RA   Stanek D.M., Pohl J., Crim J.W., Brown M.R.;
RT   "Neuropeptide F and its expression in the yellow fever mosquito, Aedes
RT   aegypti.";
RL   Peptides 23:1367-1378(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12;
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
RN   [3]
RP   PROTEIN SEQUENCE OF 28-63, AND AMIDATION AT PHE-63.
RX   PubMed=12364794; DOI=10.1126/science.1076827;
RA   Riehle M.A., Garczynski S.F., Crim J.W., Hill C.A., Brown M.R.;
RT   "Neuropeptides and peptide hormones in Anopheles gambiae.";
RL   Science 298:172-175(2002).
CC   -!- FUNCTION: An integral part of the sensory system that mediates food
CC       signaling, providing the neural basis for the regulation of food
CC       response; coordinates larval foraging and social behavior changes
CC       during development (By similarity). May have a hormonal role in
CC       females. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in hemolymph, brain and midgut.
CC       {ECO:0000269|PubMed:12182937}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT46037.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AF474405; AAM74026.1; -; mRNA.
DR   EMBL; CH477251; EAT46037.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH477629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_001655888.1; XM_001655838.1.
DR   AlphaFoldDB; Q8MP00; -.
DR   STRING; 7159.AAEL002733-PA; -.
DR   VEuPathDB; VectorBase:AAEL002733; -.
DR   HOGENOM; CLU_2905969_0_0_1; -.
DR   InParanoid; Q8MP00; -.
DR   OrthoDB; 1620251at2759; -.
DR   Proteomes; UP000008820; Chromosome 1.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Digestion;
KW   Direct protein sequencing; Hormone; Neuropeptide; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000269|PubMed:12364794"
FT   CHAIN           28..63
FT                   /note="Neuropeptide F"
FT                   /evidence="ECO:0000303|PubMed:12182937"
FT                   /id="PRO_0000025404"
FT   PROPEP          67..90
FT                   /id="PRO_0000025405"
FT   REGION          54..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         63
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:12182937,
FT                   ECO:0000269|PubMed:12364794"
SQ   SEQUENCE   90 AA;  10193 MW;  6B426C24EEA36D02 CRC64;
     MTFSTSSSFS RRALVALLVC TLLIDLSSFT DARPQDDPTS VAEAIRLLQE LETKHAQHAR
     PRFGKRSYLN PAGYGQDEQE DDWQDSTFTR