ID   NPF_DROPS               Reviewed;         102 AA.
AC   Q29B55;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 3.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Neuropeptide F;
DE            Short=NPF;
DE   Flags: Precursor;
GN   Name=npf {ECO:0000250|UniProtKB:Q9VET0}; ORFNames=GA10258;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: An integral part of the sensory system that mediates food
CC       signaling, providing the neural basis for the regulation of food
CC       response; coordinates larval foraging and social behavior changes
CC       during development. May have a hormonal role in females (By
CC       similarity). {ECO:0000250|UniProtKB:Q8MP00,
CC       ECO:0000250|UniProtKB:Q9VET0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000255}.
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DR   EMBL; CM000070; EAL27144.2; -; Genomic_DNA.
DR   RefSeq; XP_001358007.2; XM_001357970.3.
DR   AlphaFoldDB; Q29B55; -.
DR   SMR; Q29B55; -.
DR   STRING; 7237.FBpp0282638; -.
DR   EnsemblMetazoa; FBtr0284200; FBpp0282638; FBgn0070316.
DR   GeneID; 4800796; -.
DR   KEGG; dpo:Dpse_GA10258; -.
DR   eggNOG; ENOG502T6VN; Eukaryota.
DR   HOGENOM; CLU_2294604_0_0_1; -.
DR   InParanoid; Q29B55; -.
DR   OMA; PPRNNEI; -.
DR   Proteomes; UP000001819; Chromosome 2.
DR   Bgee; FBgn0070316; Expressed in insect adult head and 1 other tissue.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0071859; F:neuropeptide F receptor binding; IEA:EnsemblMetazoa.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   GO; GO:0038002; P:endocrine signaling; IEA:EnsemblMetazoa.
DR   GO; GO:0030536; P:larval feeding behavior; ISS:UniProtKB.
DR   GO; GO:0035177; P:larval foraging behavior; ISS:UniProtKB.
DR   GO; GO:0045475; P:locomotor rhythm; IEA:EnsemblMetazoa.
DR   GO; GO:0008049; P:male courtship behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0042048; P:olfactory behavior; IEA:EnsemblMetazoa.
DR   GO; GO:0032095; P:regulation of response to food; ISS:UniProtKB.
DR   GO; GO:1990834; P:response to odorant; IEA:EnsemblMetazoa.
DR   GO; GO:0035176; P:social behavior; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Digestion; Hormone;
KW   Neuropeptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   PROPEP          30..32
FT                   /evidence="ECO:0000250|UniProtKB:Q9VET0"
FT                   /id="PRO_0000283082"
FT   PEPTIDE         35..62
FT                   /note="Neuropeptide F"
FT                   /evidence="ECO:0000250|UniProtKB:Q9VET0"
FT                   /id="PRO_0000283083"
FT   PROPEP          66..102
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000283084"
FT   MOD_RES         62
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   102 AA;  11461 MW;  F14493E2EE4A7A16 CRC64;
     MSNTMRCILI VCVALTLIAA GCNVEASNSR PPRKNDVNTM ADAYKFLQDL DTYYGDRARV
     RFGKRGGPLM EMLRNRELEN NMAKSINSGG ELIRALDEEE VF