ID   NPF_HELZE               Reviewed;           7 AA.
AC   P85106;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   02-JUN-2021, entry version 26.
DE   RecName: Full=Neuropeptide F;
DE            Short=NPF;
DE   AltName: Full=Hez-MP-I;
DE   Flags: Fragment;
OS   Helicoverpa zea (Corn earworm moth) (Heliothis zea).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Heliothinae; Helicoverpa.
OX   NCBI_TaxID=7113;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   AMIDATION AT PHE-7.
RC   TISSUE=Midgut {ECO:0000269|PubMed:9692236};
RX   PubMed=9692236; DOI=10.1016/s0965-1748(98)00007-1;
RA   Huang Y., Brown M.R., Lee T.D., Crim J.W.;
RT   "RF-amide peptides isolated from the midgut of the corn earworm,
RT   Helicoverpa zea, resemble pancreatic polypeptide.";
RL   Insect Biochem. Mol. Biol. 28:345-356(1998).
CC   -!- FUNCTION: An integral part of the sensory system that mediates food
CC       signaling, providing the neural basis for the regulation of food
CC       response; coordinates larval foraging and social behavior changes
CC       during development. May have a hormonal role in females.
CC       {ECO:0000250|UniProtKB:Q8MP00, ECO:0000250|UniProtKB:Q9VET0,
CC       ECO:0000269|PubMed:9692236}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9692236}.
CC   -!- TISSUE SPECIFICITY: Expressed in the hemolymph, midgut and brain.
CC       {ECO:0000269|PubMed:9692236}.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000255}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007586; P:digestion; IEA:UniProtKB-KW.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Digestion; Direct protein sequencing; Hormone; Neuropeptide;
KW   Secreted.
FT   CHAIN           <1..7
FT                   /note="Neuropeptide F"
FT                   /id="PRO_0000283085"
FT   MOD_RES         7
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:9692236"
FT   NON_TER         1
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   7 AA;  845 MW;  69D417740DDDC6B0 CRC64;
     QAARPRF