ID   NPF_MONEX               Reviewed;          39 AA.
AC   P41967;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Neuropeptide F;
DE            Short=NPF;
OS   Moniezia expansa (Sheep tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Anoplocephalidae; Moniezia.
OX   NCBI_TaxID=28841;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT PHE-39.
RA   Maule A.G., Shaw C., Halton D.W., Thim L., Johnston C.F., Fairweather I.,
RA   Buchanan K.D.;
RT   "Neuropeptide F: a novel parasitic flatworm regulatory peptide from
RT   Moniezia expansa (Cestoda: Cyclophyllidea).";
RL   Parasitology 102:309-316(1991).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=1461689; DOI=10.1017/s0031182000074680;
RA   Maule A.G., Shaw C., Halton D.W., Brennan G.P., Johnston C.F., Moore S.;
RT   "Neuropeptide F (Moniezia expansa): localization and characterization using
RT   specific antisera.";
RL   Parasitology 105:505-512(1992).
RN   [3]
RP   STRUCTURE BY NMR.
RX   PubMed=12023801; DOI=10.1080/07391102.2002.10506802;
RA   Miskolzie M., Kotovych G.;
RT   "The NMR-derived conformation of neuropeptide F from Moniezia expansa.";
RL   J. Biomol. Struct. Dyn. 19:991-998(2002).
CC   -!- FUNCTION: May have an important physiological role in neuroregulation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
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DR   PDB; 1K8V; NMR; -; A=1-39.
DR   PDBsum; 1K8V; -.
DR   AlphaFoldDB; P41967; -.
DR   BMRB; P41967; -.
DR   SMR; P41967; -.
DR   EvolutionaryTrace; P41967; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   Pfam; PF00159; Hormone_3; 1.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..39
FT                   /note="Neuropeptide F"
FT                   /id="PRO_0000044825"
FT   MOD_RES         39
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|Ref.1"
FT   HELIX           19..35
FT                   /evidence="ECO:0007829|PDB:1K8V"
SQ   SEQUENCE   39 AA;  4594 MW;  2D61A76927DEA732 CRC64;
     PDKDFIVNPS DLVLDNKAAL RDYLRQINEY FAIIGRPRF