ID   AROE_SULTO              Reviewed;         260 AA.
AC   Q96Y95;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=STK_22730;
OS   Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)
OS   (Sulfolobus tokodaii).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfurisphaera.
OX   NCBI_TaxID=273063;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16993 / JCM 10545 / NBRC 100140 / 7;
RX   PubMed=11572479; DOI=10.1093/dnares/8.4.123;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Jin-no K., Takahashi M., Sekine M.,
RA   Baba S., Ankai A., Kosugi H., Hosoyama A., Fukui S., Nagai Y.,
RA   Nishijima K., Otsuka R., Nakazawa H., Takamiya M., Kato Y., Yoshizawa T.,
RA   Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K.,
RA   Masuda S., Yanagii M., Nishimura M., Yamagishi A., Oshima T., Kikuchi H.;
RT   "Complete genome sequence of an aerobic thermoacidophilic Crenarchaeon,
RT   Sulfolobus tokodaii strain7.";
RL   DNA Res. 8:123-140(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH;
CC         Xref=Rhea:RHEA:17737, ChEBI:CHEBI:15378, ChEBI:CHEBI:16630,
CC         ChEBI:CHEBI:36208, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.25;
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
CC       {ECO:0000305}.
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DR   EMBL; BA000023; BAB67382.1; -; Genomic_DNA.
DR   RefSeq; WP_010980357.1; NC_003106.2.
DR   AlphaFoldDB; Q96Y95; -.
DR   SMR; Q96Y95; -.
DR   STRING; 273063.STK_22730; -.
DR   EnsemblBacteria; BAB67382; BAB67382; STK_22730.
DR   GeneID; 1460355; -.
DR   KEGG; sto:STK_22730; -.
DR   PATRIC; fig|273063.9.peg.2577; -.
DR   eggNOG; arCOG01033; Archaea.
DR   OMA; FGNPIKH; -.
DR   OrthoDB; 98644at2157; -.
DR   UniPathway; UPA00053; UER00087.
DR   Proteomes; UP000001015; Chromosome.
DR   GO; GO:0004764; F:shikimate 3-dehydrogenase (NADP+) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR046346; Aminiacid_DH-like_N_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR022893; Shikimate_DH_fam.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   PANTHER; PTHR21089; PTHR21089; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF53223; SSF53223; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; NADP;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..260
FT                   /note="Shikimate dehydrogenase"
FT                   /id="PRO_0000325185"
FT   ACT_SITE        71
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255"
FT   BINDING         124..128
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   260 AA;  29435 MW;  92B011D681F4DED6 CRC64;
     MLEINYDTKL LGVVGENISY TLSPAIHNYS FQELGINAVY LAFDIKSDEF KEIFPGLVKI
     AYGLNITIPY KEIAIKYVEA QSEAKRIGAI NTIFNGKGYN TDYIAIKSLV QERIDKFETC
     TIFGAGGAAR AAIFALHDLD CSINVINRSK EKAEKLIEEM RNKNIEIKIT YNCKSDIIVN
     STPNPDFVPD ECVNGKLVID FVYKPVITSL IKRAQNKNIK TINGIEILVR QAMEAEKIWF
     GKSLEDEEVV NYLYARKLIW