ID   NPHP3_XENTR             Reviewed;        1311 AA.
AC   A0JM23;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 2.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Nephrocystin-3;
GN   Name=nphp3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for normal ciliary development and function.
CC       Inhibits disheveled-1-induced canonical Wnt-signaling activity and may
CC       also play a role in the control of non-canonical Wnt signaling that
CC       regulates planar cell polarity. Probably acts as a molecular switch
CC       between different Wnt signaling pathways. Required for proper
CC       convergent extension cell movements (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI25710.1; Type=Frameshift; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC125709; AAI25710.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001072733.2; NM_001079265.2.
DR   AlphaFoldDB; A0JM23; -.
DR   SMR; A0JM23; -.
DR   STRING; 8364.ENSXETP00000018542; -.
DR   DNASU; 780190; -.
DR   GeneID; 780190; -.
DR   KEGG; xtr:780190; -.
DR   CTD; 27031; -.
DR   Xenbase; XB-GENE-487873; nphp3.
DR   InParanoid; A0JM23; -.
DR   OrthoDB; 377554at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0097546; C:ciliary base; IBA:GO_Central.
DR   GO; GO:0097543; C:ciliary inversin compartment; IBA:GO_Central.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0060026; P:convergent extension; IBA:GO_Central.
DR   GO; GO:0007368; P:determination of left/right symmetry; IBA:GO_Central.
DR   GO; GO:0001822; P:kidney development; IBA:GO_Central.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:2000095; P:regulation of Wnt signaling pathway, planar cell polarity pathway; ISS:UniProtKB.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; -; 3.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF13176; TPR_7; 2.
DR   SMART; SM00028; TPR; 8.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50005; TPR; 8.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Reference proteome; Repeat;
KW   TPR repeat; Wnt signaling pathway.
FT   CHAIN           1..1311
FT                   /note="Nephrocystin-3"
FT                   /id="PRO_0000402546"
FT   REPEAT          889..923
FT                   /note="TPR 1"
FT   REPEAT          927..960
FT                   /note="TPR 2"
FT   REPEAT          969..1002
FT                   /note="TPR 3"
FT   REPEAT          1011..1044
FT                   /note="TPR 4"
FT   REPEAT          1077..1110
FT                   /note="TPR 5"
FT   REPEAT          1119..1152
FT                   /note="TPR 6"
FT   REPEAT          1161..1194
FT                   /note="TPR 7"
FT   REPEAT          1203..1236
FT                   /note="TPR 8"
FT   REPEAT          1245..1278
FT                   /note="TPR 9"
FT   COILED          81..183
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1311 AA;  149727 MW;  4D430BAB8D256F30 CRC64;
     MGTASSLVNP GEVIEDTYGG GGGEACVIPV EVKPKARLLR SSFRRGPRVI GASFKSTASV
     DLEYAAEYER LKKEYEIFRV SKNNEIASMQ KKEVKLDEEN KRLRAELQAL QKTYQKILRE
     KESAVEAKYQ AMERAATFEH DRDKVKRQFK IFRETKEKEI QDLLRAKRDL EAKLQRLQAQ
     GIQVFDPGES DSDDNGTELT VPGTQCEYWT SGGLGSEPSI GSMMQLQQSF RGPEFAHSSI
     DVEGPFANVN RDDWDAAVAS LLQVTPLFSQ SLWSNTVRCY LMYTAETQAE VKIFLKEYSP
     KLQRMCETSG YFFQVTFFPE ECENQYFAVR KWEIEKSSIV ILFICSSLPS CLQEDCEEAF
     LKNTEAKPCL IYHRIEDGRS DSEGLKQLLE QDTNKANKTK IVDHYGDPVE GANKIYCQLE
     QVINQDLLGI EITDPNAKDD SATKEEDDFW DVLWDVHDEQ EQMEAFQQAS HSICELGFQK
     YYDRLNDLVA APAPIPPLLI SGGPGSGKSL LLSKWIQLQQ KHSPNTLMLY HFVGRPLSSS
     SEPSLMIKRL FLKLMQHSWS VSSLSLDPAK FLEEFPHWLE KLSIRYQGNI IIIIDSIDHI
     QQSEKHMKWL IDPLPVNVRV IVSVNVETCP QAWRLWPTLH LDPLNSKDVK SLINMECGRA
     NIILTKEQER KLERHCRSAT TCNALYVTLI AKLLTWAGST GNIDDVLQLC LQCQDTVSLY
     RLALHSVQEV MPSAKDKEFM REILCFISAS RNGVSECELM ELCPGLTWPV LTSLIFHLYT
     LVLLKYSCGL IQFQHLQEIL SFNILNFKAW DAVNLEYMQG DQSIISEYRE KLIQHFNAQL
     SCDRVTWRSA DELTWLYQQQ GEKQKLHRCL MNLFVSQNLY KRGHFAELLS YWQLVGKDKI
     SMASEYFDAL KQYERSCEGE EKMTSLADLY ETLGRFLKDL GLLSQAVTPL QRSLEIRETA
     LDPDHPSVAQ SLHQLAGVYV QSKKFGNAEQ LYKQALEISE NAYGSEHMRV ARELDALAVL
     YQKQNKFEQA EQLRKKSLKI RQKSARRKGS MYGFALLRRR ALQLEELTLG KDTSDNARTL
     NELGVLYYLQ NNLETAETFL KRSLEMRERV LGADHPDCAQ SINNLAALYN EKKQYDKAEE
     LYERALDIRR RALSPDHPSL AYTVKHLAVL YKRKGKLDKA VPLYELAVEI RQKSFGPKHP
     SVATALVNLA VLYCQMKKQA EASPLYERAM KIYEDSLGRM HPRVGETLKN LAVLRYEEGD
     FEKAAELYKR AMEIKETETS VLGAKAHSGH SSSGGDTYSV QNALPVCAFP E