NPIA1_HUMAN
ID NPIA1_HUMAN Reviewed; 350 AA.
AC Q9UND3; O15102;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Nuclear pore complex-interacting protein family member A1;
DE AltName: Full=Nuclear pore complex-interacting protein;
DE Short=NPIP;
GN Name=NPIPA1; Synonyms=NPIP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=11586358; DOI=10.1038/35097067;
RA Johnson M.E., Viggiano L., Bailey J.A., Abdul-Rauf M., Goodwin G.,
RA Rocchi M., Eichler E.E.;
RT "Positive selection of a gene family during the emergence of humans and
RT African apes.";
RL Nature 413:514-519(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
RA Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
RA Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
RA Adams M.D.;
RT "Genome duplications and other features in 12 Mb of DNA sequence from human
RT chromosome 16p and 16q.";
RL Genomics 60:295-308(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
CC -!- SUBUNIT: May associate with the nuclear pore complex.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000269|PubMed:11586358}. Nucleus membrane
CC {ECO:0000269|PubMed:11586358}. Note=Colocalizes with nuclear pore
CC complex protein NUP62.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11586358}.
CC -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
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DR EMBL; AF132984; AAD34394.1; -; mRNA.
DR EMBL; AC002045; AAC05438.1; -; Genomic_DNA.
DR EMBL; AC138932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS10557.1; -.
DR RefSeq; NP_001264253.1; NM_001277324.1.
DR RefSeq; NP_008916.2; NM_006985.2.
DR RefSeq; XP_005255546.1; XM_005255489.3.
DR RefSeq; XP_011521051.1; XM_011522749.2.
DR AlphaFoldDB; Q9UND3; -.
DR SMR; Q9UND3; -.
DR BioGRID; 114701; 2.
DR IntAct; Q9UND3; 2.
DR STRING; 9606.ENSP00000331843; -.
DR TCDB; 1.I.1.1.3; the nuclear pore complex (npc) family.
DR iPTMnet; Q9UND3; -.
DR PhosphoSitePlus; Q9UND3; -.
DR BioMuta; NPIPA1; -.
DR DMDM; 238054371; -.
DR EPD; Q9UND3; -.
DR MassIVE; Q9UND3; -.
DR PaxDb; Q9UND3; -.
DR PeptideAtlas; Q9UND3; -.
DR PRIDE; Q9UND3; -.
DR Antibodypedia; 24922; 33 antibodies from 13 providers.
DR DNASU; 9284; -.
DR Ensembl; ENST00000328085.10; ENSP00000331843.6; ENSG00000183426.17.
DR GeneID; 642799; -.
DR GeneID; 9284; -.
DR KEGG; hsa:642799; -.
DR KEGG; hsa:9284; -.
DR MANE-Select; ENST00000328085.10; ENSP00000331843.6; NM_006985.4; NP_008916.2.
DR UCSC; uc002dcy.5; human.
DR CTD; 642799; -.
DR CTD; 9284; -.
DR DisGeNET; 642799; -.
DR DisGeNET; 9284; -.
DR GeneCards; NPIPA1; -.
DR HGNC; HGNC:7909; NPIPA1.
DR HPA; ENSG00000183426; Tissue enhanced (brain).
DR MIM; 606406; gene.
DR neXtProt; NX_Q9UND3; -.
DR OpenTargets; ENSG00000183426; -.
DR PharmGKB; PA31711; -.
DR VEuPathDB; HostDB:ENSG00000183426; -.
DR eggNOG; ENOG502R1NR; Eukaryota.
DR GeneTree; ENSGT00540000072033; -.
DR HOGENOM; CLU_059939_0_0_1; -.
DR InParanoid; Q9UND3; -.
DR OrthoDB; 119185at2759; -.
DR PhylomeDB; Q9UND3; -.
DR TreeFam; TF333389; -.
DR PathwayCommons; Q9UND3; -.
DR SignaLink; Q9UND3; -.
DR BioGRID-ORCS; 642799; 14 hits in 186 CRISPR screens.
DR BioGRID-ORCS; 9284; 349 hits in 524 CRISPR screens.
DR Pharos; Q9UND3; Tdark.
DR PRO; PR:Q9UND3; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9UND3; protein.
DR Bgee; ENSG00000183426; Expressed in right hemisphere of cerebellum and 95 other tissues.
DR ExpressionAtlas; Q9UND3; baseline and differential.
DR Genevisible; Q9UND3; HS.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR009443; NPIP.
DR PANTHER; PTHR15438; PTHR15438; 1.
DR Pfam; PF06409; NPIP; 2.
PE 2: Evidence at transcript level;
KW Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Translocation; Transport.
FT CHAIN 1..350
FT /note="Nuclear pore complex-interacting protein family
FT member A1"
FT /id="PRO_0000076275"
FT REGION 306..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..325
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 93
FT /note="R -> C (in dbSNP:rs1136474)"
FT /id="VAR_034141"
FT CONFLICT 61
FT /note="S -> T (in Ref. 1; AAD34394)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="R -> C (in Ref. 2; AAC05438)"
FT /evidence="ECO:0000305"
FT CONFLICT 220
FT /note="V -> A (in Ref. 2; AAC05438)"
FT /evidence="ECO:0000305"
FT CONFLICT 267
FT /note="S -> P (in Ref. 2; AAC05438)"
FT /evidence="ECO:0000305"
FT CONFLICT 324
FT /note="V -> A (in Ref. 1; AAD34394 and 2; AAC05438)"
FT /evidence="ECO:0000305"
FT CONFLICT 333
FT /note="E -> K (in Ref. 2; AAC05438)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 350 AA; 40133 MW; D003F8A277A5D324 CRC64;
MFCCLGYEWL SGGCKTWHSA WVINTLADHR HRGTDFGGSP WLLIITVFLR SYKFAISLCT
SYLCVSFLKT IFPSQNGHDG STDVQQRARR SNRRRQEGIK IVLEDIFTLW RQVETKVRAK
IRKMKVTTKV NRHDKINGKR KTAKEHLRKL SMKEREHGEK ERQVSEAEEN GKLDMKEIHT
YMEMFQRAQA LRRRAEDYYR CKITPSARKP LCNRVRMAAV EHRHSSGLPY WPYLTAETLK
NRMGHQPPPP TQQHSIIDNS LSLKTPSECL LTPLPPSALP SADDNLKTPA ECLLYPLPPS
ADDNLKTPPE CLLTPLPPSA PPSVDDNLKT PPECVCSLPF HPQRMIISRN
