NPIA5_HUMAN
ID NPIA5_HUMAN Reviewed; 350 AA.
AC E9PKD4; Q0P618;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Nuclear pore complex-interacting protein family member A5;
GN Name=NPIPA5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=E9PKD4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=E9PKD4-2; Sequence=VSP_056345, VSP_056346;
CC -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
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DR EMBL; AC126755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC137803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC138969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039707; AAH39707.1; -; mRNA.
DR CCDS; CCDS59264.1; -. [E9PKD4-1]
DR CCDS; CCDS86506.1; -. [E9PKD4-2]
DR RefSeq; NP_001264254.1; NM_001277325.1. [E9PKD4-1]
DR AlphaFoldDB; E9PKD4; -.
DR SMR; E9PKD4; -.
DR STRING; 9606.ENSP00000433597; -.
DR BioMuta; NPIPA5; -.
DR MassIVE; E9PKD4; -.
DR PaxDb; E9PKD4; -.
DR PeptideAtlas; E9PKD4; -.
DR PRIDE; E9PKD4; -.
DR Antibodypedia; 73254; 8 antibodies from 4 providers.
DR DNASU; 100288332; -.
DR Ensembl; ENST00000360151.9; ENSP00000433597.1; ENSG00000183793.14. [E9PKD4-1]
DR Ensembl; ENST00000543801.5; ENSP00000441072.1; ENSG00000183793.14. [E9PKD4-2]
DR GeneID; 100288332; -.
DR KEGG; hsa:100288332; -.
DR MANE-Select; ENST00000360151.9; ENSP00000433597.1; NM_001277325.2; NP_001264254.1.
DR UCSC; uc010uzu.3; human. [E9PKD4-1]
DR CTD; 100288332; -.
DR DisGeNET; 100288332; -.
DR GeneCards; NPIPA5; -.
DR HGNC; HGNC:41980; NPIPA5.
DR HPA; ENSG00000183793; Low tissue specificity.
DR neXtProt; NX_E9PKD4; -.
DR VEuPathDB; HostDB:ENSG00000183793; -.
DR eggNOG; ENOG502R1NR; Eukaryota.
DR GeneTree; ENSGT00540000072033; -.
DR HOGENOM; CLU_059939_0_0_1; -.
DR OrthoDB; 119185at2759; -.
DR PhylomeDB; E9PKD4; -.
DR TreeFam; TF333389; -.
DR PathwayCommons; E9PKD4; -.
DR BioGRID-ORCS; 100288332; 547 hits in 976 CRISPR screens.
DR ChiTaRS; NPIPA5; human.
DR GenomeRNAi; 100288332; -.
DR Pharos; E9PKD4; Tdark.
DR PRO; PR:E9PKD4; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; E9PKD4; protein.
DR Bgee; ENSG00000183793; Expressed in primary visual cortex and 93 other tissues.
DR ExpressionAtlas; E9PKD4; baseline and differential.
DR Genevisible; E9PKD4; HS.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR009443; NPIP.
DR PANTHER; PTHR15438; PTHR15438; 1.
DR Pfam; PF06409; NPIP; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..350
FT /note="Nuclear pore complex-interacting protein family
FT member A5"
FT /id="PRO_0000423918"
FT REGION 151..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 215..232
FT /note="VRMAAVEHRHSSGLPYWP -> CTYNLVLPGSEKKYYSHA (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_056345"
FT VAR_SEQ 233..350
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_056346"
SQ SEQUENCE 350 AA; 40105 MW; F388229DC483BAA9 CRC64;
MFCCLGYEWL SGGCKTWHSA WVINTLADHR HRGTDFGGSP WLLIITVFLR SYKFAISLCT
SYLCVSFLKT IFPSQNGHDG STDVQQRARR SNCRRQEGIK IVLEDIFTLW RQVETKVRAK
IRKMKVTTKV NRHDKINGKR KTAKEHLRKL SMKEREHGEK ERQVSEAEEN GKLDMKEIHT
YMEMFQRAQA LRRRAEDYYR CKITPSARKP LCNRVRMAAV EHRHSSGLPY WPYLTAETLK
NRMGHQPPPP TQQHSIIDNS LSLKTPSERL LYPLPPSADD NLKTPPECLL TPLPPSALPS
ADDNLKTPAE CLLTPLPPSA PPSADDNLKT PPECVCSLPF HPQRMIISRN
