NPIB3_HUMAN
ID NPIB3_HUMAN Reviewed; 1050 AA.
AC Q92617; O43332; Q504Q6; Q59F29; Q6GMR1; Q6P7T2; Q6PIE2; Q6RH21;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 5.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Nuclear pore complex-interacting protein family member B3;
DE AltName: Full=Nuclear pore complex-interacting protein-like 3;
DE AltName: Full=Protein pps22-1;
GN Name=NPIPB3; Synonyms=KIAA0220, NPIPL3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Bone marrow;
RX PubMed=9039502; DOI=10.1093/dnares/3.5.321;
RA Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O.,
RA Tanaka A., Kotani H., Miyajima N., Nomura N.;
RT "Prediction of the coding sequences of unidentified human genes. VI. The
RT coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of
RT cDNA clones from cell line KG-1 and brain.";
RL DNA Res. 3:321-329(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
RC TISSUE=Spleen;
RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA Ohara O., Nagase T., Kikuno R.F.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 690-1050 (ISOFORM 1).
RC TISSUE=Lymph, Mammary carcinoma, Pancreas, and PNS;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 917-1050 (ISOFORM 6).
RA Huang Y.-P., Cheng J., Yang Y.-J.;
RT "Cloning and identification of a new protein coding gene pps22-1 binding
RT with promoter DNA of pre-pre-S gene of hepatitis B virus.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q92617; P59634: 6; Xeno; NbExp=3; IntAct=EBI-2866234, EBI-25489038;
CC Q92617-2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12346419, EBI-16439278;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q92617-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q92617-2; Sequence=VSP_021837;
CC Name=3;
CC IsoId=Q92617-3; Sequence=VSP_021833, VSP_021838;
CC Name=4;
CC IsoId=Q92617-4; Sequence=VSP_021832, VSP_021836;
CC Name=5;
CC IsoId=Q92617-5; Sequence=VSP_021834, VSP_021835, VSP_021839;
CC Name=6;
CC IsoId=Q92617-6; Sequence=VSP_033367;
CC -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA13210.2; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAD92869.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; D86974; BAA13210.2; ALT_SEQ; mRNA.
DR EMBL; AB209632; BAD92869.1; ALT_INIT; Transcribed_RNA.
DR EMBL; AC008740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036263; AAH36263.1; -; mRNA.
DR EMBL; BC061522; AAH61522.1; -; mRNA.
DR EMBL; BC073943; AAH73943.1; -; mRNA.
DR EMBL; BC094882; AAH94882.1; -; mRNA.
DR EMBL; AY498718; AAS48701.1; -; mRNA.
DR AlphaFoldDB; Q92617; -.
DR BioGRID; 116739; 3.
DR IntAct; Q92617; 4.
DR iPTMnet; Q92617; -.
DR PhosphoSitePlus; Q92617; -.
DR BioMuta; NPIPB3; -.
DR DMDM; 215274263; -.
DR jPOST; Q92617; -.
DR MassIVE; Q92617; -.
DR PaxDb; Q92617; -.
DR PeptideAtlas; Q92617; -.
DR PRIDE; Q92617; -.
DR ProteomicsDB; 75370; -. [Q92617-6]
DR Antibodypedia; 67318; 5 antibodies from 4 providers.
DR Ensembl; ENST00000542817.1; ENSP00000444096.1; ENSG00000169246.16. [Q92617-4]
DR UCSC; uc059rux.1; human. [Q92617-1]
DR GeneCards; NPIPB3; -.
DR HGNC; HGNC:28989; NPIPB3.
DR HPA; ENSG00000169246; Low tissue specificity.
DR neXtProt; NX_Q92617; -.
DR OpenTargets; ENSG00000169246; -.
DR PharmGKB; PA164724182; -.
DR VEuPathDB; HostDB:ENSG00000169246; -.
DR GeneTree; ENSGT00540000072033; -.
DR HOGENOM; CLU_780666_0_0_1; -.
DR InParanoid; Q92617; -.
DR OMA; MPRTAMR; -.
DR OrthoDB; 119185at2759; -.
DR PhylomeDB; Q92617; -.
DR PathwayCommons; Q92617; -.
DR SignaLink; Q92617; -.
DR BioGRID-ORCS; 23117; 27 hits in 193 CRISPR screens.
DR ChiTaRS; NPIPB3; human.
DR GenomeRNAi; 23117; -.
DR Pharos; Q92617; Tdark.
DR PRO; PR:Q92617; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q92617; protein.
DR Bgee; ENSG00000169246; Expressed in right uterine tube and 94 other tissues.
DR ExpressionAtlas; Q92617; baseline and differential.
DR Genevisible; Q92617; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR009443; NPIP.
DR PANTHER; PTHR15438; PTHR15438; 4.
DR Pfam; PF06409; NPIP; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1050
FT /note="Nuclear pore complex-interacting protein family
FT member B3"
FT /id="PRO_0000050735"
FT TRANSMEM 63..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 241..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 935..1050
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..216
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021832"
FT VAR_SEQ 1..40
FT /note="MVKLSIVLTPQFLSHDQGQLTKELQQHVKSVTCPCEYLRK -> MFCCLGYE
FT WLSGGCKTWHSAW (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021833"
FT VAR_SEQ 290..327
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_021834"
FT VAR_SEQ 413..576
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_021835"
FT VAR_SEQ 515..928
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021836"
FT VAR_SEQ 515..886
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021837"
FT VAR_SEQ 577..868
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_021838"
FT VAR_SEQ 785..826
FT /note="ERLRGPLPPSADDNLKTPSERQLTPLPPSAPPSADDNIKTPA -> GRFHPQ
FT RMIISRHLPSVSSLPFHPQLHPQQMIISRHLPSVCG (in isoform 5)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_021839"
FT VAR_SEQ 947..974
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|Ref.5"
FT /id="VSP_033367"
FT CONFLICT 21
FT /note="T -> S (in Ref. 4; AAH36263)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="G -> V (in Ref. 4; AAH36263)"
FT /evidence="ECO:0000305"
FT CONFLICT 388
FT /note="P -> L (in Ref. 4; AAH36263)"
FT /evidence="ECO:0000305"
FT CONFLICT 521
FT /note="A -> P (in Ref. 1; BAA13210)"
FT /evidence="ECO:0000305"
FT CONFLICT 526
FT /note="A -> APPSA (in Ref. 1; BAA13210)"
FT /evidence="ECO:0000305"
FT CONFLICT 584
FT /note="Missing (in Ref. 2; BAD92869)"
FT /evidence="ECO:0000305"
FT CONFLICT 610..612
FT /note="HLP -> YLL (in Ref. 1; BAA13210)"
FT /evidence="ECO:0000305"
FT CONFLICT 617
FT /note="G -> F (in Ref. 1; BAA13210)"
FT /evidence="ECO:0000305"
FT CONFLICT 621..623
FT /note="PQQ -> HQP (in Ref. 1; BAA13210)"
FT /evidence="ECO:0000305"
FT CONFLICT 622..623
FT /note="QQ -> ER (in Ref. 2; BAD92869)"
FT /evidence="ECO:0000305"
FT CONFLICT 664
FT /note="Q -> E (in Ref. 2; BAD92869)"
FT /evidence="ECO:0000305"
FT CONFLICT 675
FT /note="V -> I (in Ref. 1; BAA13210)"
FT /evidence="ECO:0000305"
FT CONFLICT 707
FT /note="Q -> R (in Ref. 1; BAA13210 and 2; BAD92869)"
FT /evidence="ECO:0000305"
FT CONFLICT 766
FT /note="P -> T (in Ref. 1; BAA13210)"
FT /evidence="ECO:0000305"
FT CONFLICT 825
FT /note="P -> S (in Ref. 4; AAH73943)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1050 AA; 116847 MW; 342657B7685C9167 CRC64;
MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINHHD KINGKRKTAR
KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
NRMGHQPPPP TQQHSITDNS LSLKTPPECL LTPLPPSADD NLKTPPECVL TPLPPSADDN
LKTPPECVLT PLPPSADDNL KTPPECLLTP LPPSADDNLK TPPECLLTPL PPSALPSAPP
SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP
PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL
PPSAPPSADD NIKTPAERLR GPLPPSADDN LKTPSERQLT ALPPSADDNI KTPAERLRGP
LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAFHPQ RMIISRHLPS VSSLPFHPQL
HPQQMIISRH LPSVCGGRFH PQQMIISRHL PSVSSLPFHP QLHPQQMIIS RHLPSVCGGR
FHPQRMIISR HLPSVSSLPF HPQLHPQQMI ISRHLPSVCG GRFHPQQMII SRHLPSVSSL
PFHPQLHPQQ MIISRHLPSV CGGRFHPQRM IISRHLPSVS SLPFHPQLHP QQMIISRHLP
SVCGERLRGP LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAERLR GPLPPSADDN
LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD DNLKTPSERQ LTPLPPSAPP
SADDNIKTPA ERLRGPLPPS ADDNLKTPPL ATQEAEAEKP RKPKRQRAAE MEPPPEPKRR
RVGDVEPSRK PKRRRAADVE PSSPEPKRRR VGDVEPSRKP KRRRAADVEP SSPEPKRRRV
GDVEPSRKPK RRRAADVEPS LPEPKRRRLS
