NPIB4_HUMAN
ID NPIB4_HUMAN Reviewed; 1138 AA.
AC C9JG80;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 2.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Nuclear pore complex-interacting protein family member B4;
GN Name=NPIPB4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
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DR EMBL; AC092375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; C9JG80; -.
DR SMR; C9JG80; -.
DR STRING; 9606.ENSP00000404439; -.
DR iPTMnet; C9JG80; -.
DR PhosphoSitePlus; C9JG80; -.
DR BioMuta; NPIPB4; -.
DR jPOST; C9JG80; -.
DR MassIVE; C9JG80; -.
DR PaxDb; C9JG80; -.
DR PeptideAtlas; C9JG80; -.
DR PRIDE; C9JG80; -.
DR Antibodypedia; 76105; 1 antibodies from 1 providers.
DR Ensembl; ENST00000415645.6; ENSP00000404439.2; ENSG00000185864.18.
DR UCSC; uc059rwg.1; human.
DR GeneCards; NPIPB4; -.
DR HGNC; HGNC:41985; NPIPB4.
DR HPA; ENSG00000185864; Low tissue specificity.
DR neXtProt; NX_C9JG80; -.
DR OpenTargets; ENSG00000185864; -.
DR VEuPathDB; HostDB:ENSG00000185864; -.
DR eggNOG; ENOG502TDBV; Eukaryota.
DR GeneTree; ENSGT00540000072033; -.
DR HOGENOM; CLU_308511_0_0_1; -.
DR OMA; PPPTEMW; -.
DR PhylomeDB; C9JG80; -.
DR TreeFam; TF333389; -.
DR ChiTaRS; NPIPB4; human.
DR Pharos; C9JG80; Tdark.
DR PRO; PR:C9JG80; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; C9JG80; protein.
DR Bgee; ENSG00000185864; Expressed in sural nerve and 99 other tissues.
DR ExpressionAtlas; C9JG80; baseline and differential.
DR Genevisible; C9JG80; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR009443; NPIP.
DR PANTHER; PTHR15438; PTHR15438; 6.
DR Pfam; PF06409; NPIP; 2.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1138
FT /note="Nuclear pore complex-interacting protein family
FT member B4"
FT /id="PRO_0000423920"
FT TRANSMEM 63..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 241..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 873..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1138 AA; 126699 MW; D7BDA22623DE8263 CRC64;
MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
ICMHTKKRVS SFRGNKIVLK DVITLRRHVE TKVRAKIRKR KVTTKINHHD KINGKRKTAR
KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
NRMGHQPPPP TQQHSITDNS LSLKTPPECL LTPLPPSADD NLKTPPECVL TPLPPSADDN
LKTPPECVLT PLPPSADDNL KTPPECLLTP LPPSADDKLK TPPECLLTPL PPSALPSAPP
SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP
PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL
PPSAPPSADD NIKTPAERLR GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER
LRGPLPPSAD DNLKTPSERQ LTPLPPSAPP SADDNIKTPA ERLRGPLPPS ADDNLKTPSE
RQLTPLPPSA PPSADDNIKT PAFHPQRMII SRHLPSVSSL PFHPQLHPQQ MIISRYLLSV
CGFRFHHQPM IISRHLPSVS SLPFHPQLHP QQMIISRHLP SVCGGRFHPQ RMIISRHLPS
VSSLPFHPQL HPQQMIISRH LPSVCGGRFH PQRMIISRHL PSVSSLPFHP QLHPQQMIIS
RHLPSVCGGR FHPQRMIISR HLPSVSSLPF HPQLHPQQMI ISRHLPSVCG GRFHPQRMII
SRHLPSVSSL PFHPQLHPQQ MIISRHLPSV CGERLRGPLP PSADDNLKTP SERQLTPLPP
SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAERLR
GPLPPSADDN LKTPSERQLT PLPPSAPPSA DDNIKTPAER LRGPLPPSAD DNLKTPPLAT
QEAEAEKPRK PKRQRAAEME PPPEPKRRRV GDVEPSRKPK RRRAADVEPS SPEPKRRRVG
DVEPSRKPKR RRAADVEPSS PEPKRRRVGD VEPSRKPKRR RAADVEPSLP EPKRRRLS
