NPIB5_HUMAN
ID NPIB5_HUMAN Reviewed; 1133 AA.
AC A8MRT5; B4DK13;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 3.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Nuclear pore complex-interacting protein family member B5;
GN Name=NPIPB5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK296338; BAG59025.1; -; mRNA.
DR EMBL; AC106788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS45443.1; -.
DR RefSeq; NP_001129337.1; NM_001135865.1.
DR AlphaFoldDB; A8MRT5; -.
DR BioGRID; 935725; 3.
DR IntAct; A8MRT5; 1.
DR STRING; 9606.ENSP00000440703; -.
DR iPTMnet; A8MRT5; -.
DR PhosphoSitePlus; A8MRT5; -.
DR BioMuta; NPIPB5; -.
DR jPOST; A8MRT5; -.
DR MassIVE; A8MRT5; -.
DR PaxDb; A8MRT5; -.
DR PeptideAtlas; A8MRT5; -.
DR PRIDE; A8MRT5; -.
DR Ensembl; ENST00000424340.6; ENSP00000440703.1; ENSG00000243716.11.
DR Ensembl; ENST00000517539.5; ENSP00000430633.1; ENSG00000243716.11.
DR GeneID; 100132247; -.
DR KEGG; hsa:100132247; -.
DR MANE-Select; ENST00000424340.7; ENSP00000440703.1; NM_001395849.1; NP_001382778.1.
DR UCSC; uc010vbv.3; human.
DR CTD; 100132247; -.
DR GeneCards; NPIPB5; -.
DR HGNC; HGNC:37233; NPIPB5.
DR HPA; ENSG00000243716; Low tissue specificity.
DR neXtProt; NX_A8MRT5; -.
DR OpenTargets; ENSG00000243716; -.
DR VEuPathDB; HostDB:ENSG00000243716; -.
DR eggNOG; ENOG502TDBV; Eukaryota.
DR GeneTree; ENSGT00540000072033; -.
DR HOGENOM; CLU_308511_0_0_1; -.
DR OMA; DEFPMPQ; -.
DR OrthoDB; 119185at2759; -.
DR PhylomeDB; A8MRT5; -.
DR PathwayCommons; A8MRT5; -.
DR BioGRID-ORCS; 100132247; 135 hits in 655 CRISPR screens.
DR ChiTaRS; NPIPB5; human.
DR GenomeRNAi; 100132247; -.
DR Pharos; A8MRT5; Tdark.
DR PRO; PR:A8MRT5; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; A8MRT5; protein.
DR Bgee; ENSG00000243716; Expressed in right uterine tube and 172 other tissues.
DR ExpressionAtlas; A8MRT5; baseline and differential.
DR Genevisible; A8MRT5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR009443; NPIP.
DR PANTHER; PTHR15438; PTHR15438; 6.
DR Pfam; PF06409; NPIP; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..1133
FT /note="Nuclear pore complex-interacting protein family
FT member B5"
FT /id="PRO_0000348052"
FT TRANSMEM 60..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 241..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1018..1133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 905
FT /note="I -> V (in Ref. 1; BAG59025)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1133 AA; 126459 MW; 7F9A2A0B35AB161D CRC64;
MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINTLADHHH RGTDFGGSPW
LHVIIAFPTS YKVVITLWIV YLWVSLLKTI FWSRNGHDGS TDVQQRAWRS NRRRQEGLRS
ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINHHD KINGKRKTAR
KQKMFQRAQE LRRRAEDYHK CKIPPSARKA LCNWVRMAAA EHRHSSGLPY WPYLTAETLK
NRMGHQPPPP TQQHSITDNS LSLKTPPECL LTPLPPSADD NLKTPPECVL TPLPPSADDN
LKTPPECVLT PLPPSADDNL KTPPECLLTP LPPSADDNLK TPPECLLTPL PPSALPSAPP
SADDNLKTRA ECLLHPLPPS ADDNLKTPSE RQLTPLPPSA PPSADDNIKT PAERLRGPLP
PSADDNLKTP SERQLTPLPP SAPPSADDNI KTPAERLRGP LPPSADDNLK TPSERQLTPL
PPSAPPSADD NIKTPAERLR GPLPPSADDN LKTPSERQLT ALPPSADDNI KTPAERLRGP
LPPSADDNLK TPSERQLTPL PPSAPPSADD NIKTPAFHPQ RMISRHLPSV SSLPFHPQLH
PQQMIISRYL LSVCGFRFHH QPMIISRHLP SVSSLPFHPQ LHPQQMIISR HLPSVCGGRF
HPERMIISRH LPSVSSLPFH PQLHPQQMII SRHLPSVCGG RFHPQQMIIS RHLPSVSSLP
FHPQLHPQQM IISRHLPSVC GGRFHPQRMI ISRHLPSVSS LPFHPQLHPQ QMIISRHLPS
VCGGRFHPQQ MIISRHLPSV SSLPFHPQLH PQQMIISRHL PSVCGGRFHP QRMIISRHLP
SVSSLPFHPQ LHPQQMIISR HLPSVCGERL RGPLPPSADD NLKTPSERQL TPLPPSAPPS
ADDNIKTPAE RLRGPLPPSA DDNLKTPSER QLTPLPPSAP PSADDNIKTP AERLRGPLPP
SADDNLKTPS ERQLTPLPPS APPSADDNIK TPAERLRGPL PPSADDNLKT PPLATQEAEA
EKPRKPKRQR AAEMEPPPEP KRRRVGDVEP SRKPKRRRAA DVEPSSPEPK RRRVGDVEPS
RKPKRRRAAD VEPSSPEPKR RRVGDVEPSR KPKRRRAADV EPSLPEPKRR RLS
