NPIB7_HUMAN
ID NPIB7_HUMAN Reviewed; 414 AA.
AC O75200; E7ERT9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 3.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Nuclear pore complex-interacting protein family member B7;
DE AltName: Full=Nuclear pore complex-interacting protein-like 1;
DE Flags: Precursor;
GN Name=NPIPB7; Synonyms=NPIPL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10493829; DOI=10.1006/geno.1999.5927;
RA Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J.,
RA Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X.,
RA Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C.,
RA Adams M.D.;
RT "Genome duplications and other features in 12 Mb of DNA sequence from human
RT chromosome 16p and 16q.";
RL Genomics 60:295-308(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC27429.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002544; AAC27429.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC138894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; O75200; -.
DR GlyGen; O75200; 1 site.
DR iPTMnet; O75200; -.
DR PhosphoSitePlus; O75200; -.
DR BioMuta; NPIPB7; -.
DR MassIVE; O75200; -.
DR PaxDb; O75200; -.
DR PeptideAtlas; O75200; -.
DR PRIDE; O75200; -.
DR ProteomicsDB; 17851; -.
DR Antibodypedia; 77161; 1 antibodies from 1 providers.
DR Ensembl; ENST00000452313.5; ENSP00000405348.1; ENSG00000233232.7.
DR MANE-Select; ENST00000452313.6; ENSP00000405348.1; NM_001396030.1; NP_001382959.1.
DR UCSC; uc059smh.1; human.
DR GeneCards; NPIPB7; -.
DR HGNC; HGNC:33832; NPIPB7.
DR HPA; ENSG00000233232; Tissue enhanced (testis).
DR neXtProt; NX_O75200; -.
DR OpenTargets; ENSG00000233232; -.
DR VEuPathDB; HostDB:ENSG00000233232; -.
DR GeneTree; ENSGT00540000072033; -.
DR InParanoid; O75200; -.
DR PhylomeDB; O75200; -.
DR TreeFam; TF333389; -.
DR ChiTaRS; NPIPB7; human.
DR Pharos; O75200; Tdark.
DR PRO; PR:O75200; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; O75200; protein.
DR Bgee; ENSG00000233232; Expressed in left testis and 97 other tissues.
DR ExpressionAtlas; O75200; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR009443; NPIP.
DR PANTHER; PTHR15438; PTHR15438; 1.
DR Pfam; PF06409; NPIP; 2.
PE 3: Inferred from homology;
KW Coiled coil; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..414
FT /note="Nuclear pore complex-interacting protein family
FT member B7"
FT /id="PRO_0000326066"
FT REGION 242..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 414 AA; 47714 MW; 34224B51C5C6E2F7 CRC64;
MRLRFWLLIW LLLGFISHQP TPVINSLAVY RHRETDFGVG VRDHPGQHGK TPSPQKLDNL
IIIIIGFLRR YTFNVLFCTS CLCVSFLKTI FWSRNGHDGS MDVQQRAWRS NRSRQKGLRS
ICMHTKKRVS SFRGNKIGLK DVITLRRHVE TKVRAKIRKR KVTTKINRHD KINGKRKTAR
KQKMFQRAQE LRRRAEDYHK CKIPPSARKP LCNWVRMAAA EHCHSSGLPY WLYLTAETLK
NRMGRQPPPP TQQHSITDNS LSLKTPPECL LTPLPPSVDD NIKECPLAPL PPSPLPPSVD
DNLKECLFVP LPPSPLPPSV DDNLKECLFV PLPPSPLPPS VDDNLKTPPL ATQEAEVEKP
PKPKRWRVDE VEQSPKPKRQ REAEAQQLPK PKRRRLSKLR TRHCTQAWAI RINP
