NPIB8_HUMAN
ID NPIB8_HUMAN Reviewed; 432 AA.
AC E9PQR5;
DT 16-OCT-2013, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Nuclear pore complex-interacting protein family member B8;
GN Name=NPIPB8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
CC -!- SIMILARITY: Belongs to the NPIP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC020765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC145285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS81963.1; -.
DR RefSeq; NP_001297065.1; NM_001310136.1.
DR RefSeq; XP_016879113.1; XM_017023624.1.
DR AlphaFoldDB; E9PQR5; -.
DR SMR; E9PQR5; -.
DR STRING; 9606.ENSP00000434399; -.
DR BioMuta; NPIPB8; -.
DR MassIVE; E9PQR5; -.
DR PaxDb; E9PQR5; -.
DR PeptideAtlas; E9PQR5; -.
DR PRIDE; E9PQR5; -.
DR DNASU; 728734; -.
DR Ensembl; ENST00000529716.5; ENSP00000434399.1; ENSG00000255524.8.
DR Ensembl; ENST00000683297.1; ENSP00000507410.1; ENSG00000255524.8.
DR GeneID; 728734; -.
DR KEGG; hsa:728734; -.
DR MANE-Select; ENST00000683297.1; ENSP00000507410.1; NM_001310136.2; NP_001297065.1.
DR UCSC; uc059soj.1; human.
DR CTD; 728734; -.
DR DisGeNET; 728734; -.
DR GeneCards; NPIPB8; -.
DR HGNC; HGNC:37490; NPIPB8.
DR HPA; ENSG00000255524; Tissue enriched (testis).
DR neXtProt; NX_E9PQR5; -.
DR VEuPathDB; HostDB:ENSG00000255524; -.
DR eggNOG; ENOG502TDBV; Eukaryota.
DR GeneTree; ENSGT00540000072033; -.
DR HOGENOM; CLU_059939_0_0_1; -.
DR InParanoid; E9PQR5; -.
DR OrthoDB; 119185at2759; -.
DR PhylomeDB; E9PQR5; -.
DR TreeFam; TF333389; -.
DR PathwayCommons; E9PQR5; -.
DR SignaLink; E9PQR5; -.
DR BioGRID-ORCS; 728734; 0 hits in 33 CRISPR screens.
DR ChiTaRS; NPIPB8; human.
DR GenomeRNAi; 728734; -.
DR Pharos; E9PQR5; Tdark.
DR PRO; PR:E9PQR5; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; E9PQR5; protein.
DR Bgee; ENSG00000255524; Expressed in left testis and 90 other tissues.
DR ExpressionAtlas; E9PQR5; baseline and differential.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR009443; NPIP.
DR PANTHER; PTHR15438; PTHR15438; 1.
DR Pfam; PF06409; NPIP; 2.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..432
FT /note="Nuclear pore complex-interacting protein family
FT member B8"
FT /id="PRO_0000423922"
FT REGION 260..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 432 AA; 49617 MW; 408BDEA42C5EB928 CRC64;
MVKLSIVLTP QFLSHDQGQL TKELQQHVKS VTCPCEYLRK VINSLAVYRH RETDFGVGVR
DHPGQHGKTP SPQKLDNLII IIIGFLRCYT FNILFCTSCL CVSFLKTIFW SRNGHDGSMD
VQQRAWRSNR SRQKGLRSIC MHTKKRVSSF RGNKIGLKDV ITLRRHVETK VRAKIRKRKV
TTKINRHDKI NGKRKTARKQ KMFQRAQELR RRAEDYHKCK IPPSARKPLC NWVRMAAAEH
RHSSGLPYWL YLTAETLKNR MGRQPPPPTQ QHSITDNSLS LKTPPECLLT PLPPSVDDNI
KECPLAPLPP SPLPPSVDDN LKECLFVPLP PSPLPPSVDD NLKECLFVPL PPSPLPPSVD
DNLKTPPLAT QEAEVEKPPK PKRWRVDEVE QSPKPKRQRE AEAQQLPKPK RRRLSKLRTR
HCTQAWAIRI NP
