ID   NPL4_DEBHA              Reviewed;         566 AA.
AC   Q6BRJ9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Nuclear protein localization protein 4;
GN   Name=NPL4; OrderedLocusNames=DEHA2D15818g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the import of nuclear-targeted proteins into the
CC       nucleus and the export of poly(A) RNA out of the nucleus. Has a role in
CC       the endoplasmic reticulum-associated degradation (ERAD) pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC       Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Localizes mainly at the nuclear periphery and
CC       the endoplasmic reticulum membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPL4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG87342.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR382136; CAG87342.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_459171.2; XM_459171.2.
DR   AlphaFoldDB; Q6BRJ9; -.
DR   SMR; Q6BRJ9; -.
DR   STRING; 4959.XP_459171.2; -.
DR   EnsemblFungi; CAG87342; CAG87342; DEHA2D15818g.
DR   GeneID; 2901287; -.
DR   KEGG; dha:DEHA2D15818g; -.
DR   eggNOG; KOG2834; Eukaryota.
DR   HOGENOM; CLU_017172_0_0_1; -.
DR   InParanoid; Q6BRJ9; -.
DR   OrthoDB; 1106766at2759; -.
DR   Proteomes; UP000000599; Chromosome D.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd08061; MPN_NPL4; 1.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR016563; Npl4.
DR   InterPro; IPR007717; NPL4_C.
DR   InterPro; IPR007716; NPL4_Zn-bd_put.
DR   PANTHER; PTHR12710; PTHR12710; 1.
DR   Pfam; PF05021; NPL4; 1.
DR   Pfam; PF05020; zf-NPL4; 1.
DR   PIRSF; PIRSF010052; Polyub_prc_Npl4; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; mRNA transport; Nucleus;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..566
FT                   /note="Nuclear protein localization protein 4"
FT                   /id="PRO_0000339444"
FT   DOMAIN          238..375
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   566 AA;  63265 MW;  F04DC95BECB21DA7 CRC64;
     MFRINVDAGS DFLLVLEELV GKLSTNDIQS IYISDKPNSK GEQANSLCGR SVNDLGFKNG
     DLLFVTYEST GEPPKTESSA PLTTAKTTNG ANVSINMNDI SIPINKGPGP LKVDQLPVDG
     LLDKEEGMIM RPRSDLCRHG DKGMCEYCSP LPPWDKDYRK EKGFKHMSYH AHLNEINESK
     NNRNNATSYM APLEEPNYNI NLNCPSGSHA PYPKGICSKC QPPVITLQQQ QFRMVDHVEY
     ADSTILNKFI DSWRTTGVQR FGILYGRYEQ FDKVPLGIKA VVEAIYEPPQ SGELDGLTLL
     PWENERQVDE IAASLGLYKV GMTFTDLTDS GAKNGTVLCK RHKNSYFLSC LEVIMAAKYQ
     VSNPNITKHS NSGRFSSKFV TCVISGGMNG EIEPRSYQVS NSAEALIKAD IITGSTQPSM
     LYINDSEGKR YVPDVFYSKI NEYGLEVKTN AKPAFPVEFL LVSLSDSFPL DPSPMFRENF
     PIENRDFMGD LQDLKSAYNY LNADPGDGSQ LFDFHFLTYI AKTGILSHDE LKLVLSYVRN
     KDQTDYLQLV ESPGWMTFIT ILEQSV