ID   NPL4_LODEL              Reviewed;         600 AA.
AC   A5DX93;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Nuclear protein localization protein 4;
GN   Name=NPL4; ORFNames=LELG_01980;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Involved in the import of nuclear-targeted proteins into the
CC       nucleus and the export of poly(A) RNA out of the nucleus. Has a role in
CC       the endoplasmic reticulum-associated degradation (ERAD) pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC       Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Localizes mainly at the nuclear periphery and
CC       the endoplasmic reticulum membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPL4 family. {ECO:0000305}.
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DR   EMBL; CH981525; EDK43801.1; -; Genomic_DNA.
DR   RefSeq; XP_001527151.1; XM_001527101.1.
DR   AlphaFoldDB; A5DX93; -.
DR   SMR; A5DX93; -.
DR   STRING; 379508.A5DX93; -.
DR   EnsemblFungi; EDK43801; EDK43801; LELG_01980.
DR   GeneID; 5233850; -.
DR   KEGG; lel:LELG_01980; -.
DR   VEuPathDB; FungiDB:LELG_01980; -.
DR   eggNOG; KOG2834; Eukaryota.
DR   HOGENOM; CLU_017172_0_0_1; -.
DR   InParanoid; A5DX93; -.
DR   OMA; KWSRTGR; -.
DR   OrthoDB; 1106766at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd08061; MPN_NPL4; 1.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR016563; Npl4.
DR   InterPro; IPR007717; NPL4_C.
DR   InterPro; IPR024682; Npl4_Ub-like_dom.
DR   InterPro; IPR007716; NPL4_Zn-bd_put.
DR   PANTHER; PTHR12710; PTHR12710; 1.
DR   Pfam; PF05021; NPL4; 1.
DR   Pfam; PF11543; UN_NPL4; 1.
DR   Pfam; PF05020; zf-NPL4; 1.
DR   PIRSF; PIRSF010052; Polyub_prc_Npl4; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; mRNA transport; Nucleus;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..600
FT                   /note="Nuclear protein localization protein 4"
FT                   /id="PRO_0000339447"
FT   DOMAIN          265..402
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   REGION          109..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   600 AA;  66904 MW;  0897EB47CD0EC6B6 CRC64;
     MSLILRFRSK DGMFRVNTDS SSTFQTVVDQ LSLKLPTTDY DQITVSDKPN NKNDLGSQAK
     TLLSILHQTI SELQLKNGDL LFLNYSNAIP QGTLASTSST KLQSGSIAIN SSGGSSGPAT
     ASGANASTIR VSPTTHGPVK VSQLPIDDEL DSQDGILSRP ISSMCRHGAK GMCEYCSPLP
     PWDENYRKEH AIKHISYHAY LKQQMAKFNK KELSSSYIAP LENPNYAINL NCNEGHQSYP
     RGICSKCQPL PITLQLQKFR MVDHLEYASH TILNDFINVW RSTGVQRFGY LYGRYEKFDK
     VPMGIKAVVE AIYEPPQHDE LDGLTLLDWE DEPIVDAIAA KLGLQKVGIV FTDLTDSGNR
     DGTVLCKRHK DSYFLTNLEI IMAAKFQIKN PNITKYANLG EFSSKFVTCV ISGGLQGEIE
     PRSYQVSSSA EGLVKADIIT GSTQPSQIYV NGNNDTRYVP DIQYSKINEY GLEVKSNAKP
     TFPGEFLLVS LTDSFPIDPK PLFTSKISYV IENREFLGHG DIDGLDHLQN LSSVAKFIKL
     NDSELFDFHW LVHVAKMGIL SEEELSLLCK YVKEKKYDDY LQLMESGGWM TFLTILEQST