NPL4_ORYSJ
ID NPL4_ORYSJ Reviewed; 415 AA.
AC Q9AS33; Q0JMN0;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=NPL4-like protein;
GN OrderedLocusNames=Os01g0377700, LOC_Os01g27990; ORFNames=P0416G11.21-1;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12447438; DOI=10.1038/nature01184;
RA Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT "The genome sequence and structure of rice chromosome 1.";
RL Nature 420:312-316(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
CC -!- FUNCTION: May be part of a complex that binds ubiquitinated proteins
CC and that is necessary for the export of misfolded proteins from the ER
CC to the cytoplasm, where they are degraded by the proteasome.
CC {ECO:0000250}.
CC -!- PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9AS33-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9AS33-2; Sequence=VSP_018607, VSP_018608;
CC -!- SIMILARITY: Belongs to the NPL4 family. {ECO:0000305}.
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DR EMBL; AP002968; BAB39260.1; -; Genomic_DNA.
DR EMBL; AP008207; BAF04998.1; -; Genomic_DNA.
DR EMBL; AP014957; BAS72213.1; -; Genomic_DNA.
DR EMBL; AP014957; BAS72214.1; -; Genomic_DNA.
DR EMBL; AK059266; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK107503; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; XP_015621888.1; XM_015766402.1. [Q9AS33-1]
DR AlphaFoldDB; Q9AS33; -.
DR SMR; Q9AS33; -.
DR STRING; 4530.OS01T0377700-02; -.
DR iPTMnet; Q9AS33; -.
DR PaxDb; Q9AS33; -.
DR PRIDE; Q9AS33; -.
DR EnsemblPlants; Os01t0377700-01; Os01t0377700-01; Os01g0377700. [Q9AS33-2]
DR EnsemblPlants; Os01t0377700-02; Os01t0377700-02; Os01g0377700. [Q9AS33-1]
DR GeneID; 4325451; -.
DR Gramene; Os01t0377700-01; Os01t0377700-01; Os01g0377700. [Q9AS33-2]
DR Gramene; Os01t0377700-02; Os01t0377700-02; Os01g0377700. [Q9AS33-1]
DR KEGG; osa:4325451; -.
DR eggNOG; KOG2834; Eukaryota.
DR HOGENOM; CLU_052923_0_0_1; -.
DR InParanoid; Q9AS33; -.
DR OMA; DYTMSTA; -.
DR OrthoDB; 1106766at2759; -.
DR UniPathway; UPA00144; -.
DR Proteomes; UP000000763; Chromosome 1.
DR Proteomes; UP000059680; Chromosome 1.
DR Genevisible; Q9AS33; OS.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd08061; MPN_NPL4; 1.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR016563; Npl4.
DR InterPro; IPR007717; NPL4_C.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12710; PTHR12710; 2.
DR Pfam; PF05021; NPL4; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50249; MPN; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..415
FT /note="NPL4-like protein"
FT /id="PRO_0000238460"
FT DOMAIN 130..279
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT VAR_SEQ 333..351
FT /note="GPLSTGFPIENRGNPVAMS -> VFLFFPTLLHSIMNLQFTK (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:12869764"
FT /id="VSP_018607"
FT VAR_SEQ 352..415
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12869764"
FT /id="VSP_018608"
FT CONFLICT 306
FT /note="E -> G (in Ref. 5; AK059266)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 415 AA; 44891 MW; FE4BC8355CC3ADB0 CRC64;
MILRIRSRDG TDRITVPDPA AATVGDLQRL IAARVTVPVP LQRLSLDPAL LLPSSASAAL
LADPAAPLSS LRLSNGSFVY LSYPPDARSS QPPPPKALSA AGSFGKKMTM DDLIARQIRV
TRQEAPLCAA ASFDRDSANA FQLHVAESLA FATKRAGFLY GRVDADTKEV FVDFIYEPPQ
VGTEDVVQLM RDAQEEARVD AIAHGLGMRR VGLVFTQAVG RKTSDTGEYT MSNREVLQAT
ELQAEGGIPE WVTAIVKLEV GDDGSGDVHF EAFQMSEICV KLFKDGVLET EIGDKDDPRL
SKMRKEVVAG GKDTMEVDND FFLVPVKISD HQGPLSTGFP IENRGNPVAM SALKSHLDRA
KHLPFVKRIS DFHLLLLVAA FLDIKADVPA LTACVKNQSV VPEGYQLLIE SLAGA
