ID   NPL4_PHANO              Reviewed;         653 AA.
AC   P0C7N6; Q0UV64;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Nuclear protein localization protein 4;
GN   Name=NPL4; ORFNames=SNOG_04349;
OS   Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS   blotch fungus) (Parastagonospora nodorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC   Parastagonospora.
OX   NCBI_TaxID=321614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX   PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA   Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA   Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA   Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT   "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT   analysis of the wheat pathogen Stagonospora nodorum.";
RL   Plant Cell 19:3347-3368(2007).
CC   -!- FUNCTION: Involved in the import of nuclear-targeted proteins into the
CC       nucleus and the export of poly(A) RNA out of the nucleus. Has a role in
CC       the endoplasmic reticulum-associated degradation (ERAD) pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC       Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Localizes mainly at the nuclear periphery and
CC       the endoplasmic reticulum membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPL4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT88110.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH445330; EAT88110.2; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; P0C7N6; -.
DR   SMR; P0C7N6; -.
DR   STRING; 13684.SNOT_04350; -.
DR   PRIDE; P0C7N6; -.
DR   eggNOG; KOG0989; Eukaryota.
DR   eggNOG; KOG2834; Eukaryota.
DR   InParanoid; P0C7N6; -.
DR   OMA; KWSRTGR; -.
DR   OrthoDB; 1071197at2759; -.
DR   Proteomes; UP000001055; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd08061; MPN_NPL4; 1.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR016563; Npl4.
DR   InterPro; IPR007717; NPL4_C.
DR   InterPro; IPR007716; NPL4_Zn-bd_put.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12710; PTHR12710; 1.
DR   Pfam; PF05021; NPL4; 1.
DR   Pfam; PF05020; zf-NPL4; 1.
DR   PIRSF; PIRSF010052; Polyub_prc_Npl4; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; mRNA transport; Nucleus;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..653
FT                   /note="Nuclear protein localization protein 4"
FT                   /id="PRO_0000339453"
FT   DOMAIN          253..390
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   REGION          596..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   653 AA;  71984 MW;  B65C99178D37C77F CRC64;
     MILRFVSKEG QFRLTVQPDS TFPELLAQIA EKLPKSVDLQ SVTVSNRPQG GDARKISELK
     GVSFKQVGLS HGAQLFLGFE DQSTASNGHA TAPTGANRLN GKVVEASDMP SVPLGSPTQV
     IKNPWEVVRQ SPLDDKLDRQ DGKIHRKRDA RMCTHGPKGM CDYCMPLEPY AAAYLAEKKI
     KHLSFHSYLR KVNSAKNRPE LGSSYIPPLT EPYYRVRPDC PSGHKPFPAG ICTKCQPGAI
     SLKPQEYRMV DHVEFASIQV VDDLINFWRN TGCQRLGFLY GRYEEYTEVP LGTKAVVETI
     YEPPQVNELD GISLGDWDNE KEIDEIAAQC GLQRVGVIFT DLLDADKGDG SVICKRHIDS
     YYLSSLEIAF AARYQAKYPR PTKWSETGKF GSNFVTCVIS GDDQGQIGIS SYQASNDAVE
     MVRADIIEPS AEPSVMLVQS EDDNEALNRA RYIPEVFYRR INEHGANVQE NAKPDFPVEY
     LFVTLTHGFP TQPNPLFTGG KFPIENREIM GEMPDVSALG KSLNAKANGL ALNTTSGLNA
     ISNFHMLCFI HNLGILSKDE ESLLFKVAST HDTSEGSALQ HTGGWATLLT ILKESGERPP
     KRSYASPSFS ATGRGAAHPG EKNRLMRQPS HGSDSDSVQL AKRLKGASLK GKE