ID   NPL4_PICGU              Reviewed;         564 AA.
AC   A5DBC9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Nuclear protein localization protein 4;
GN   Name=NPL4; ORFNames=PGUG_00584;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Involved in the import of nuclear-targeted proteins into the
CC       nucleus and the export of poly(A) RNA out of the nucleus. Has a role in
CC       the endoplasmic reticulum-associated degradation (ERAD) pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC       Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Localizes mainly at the nuclear periphery and
CC       the endoplasmic reticulum membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPL4 family. {ECO:0000305}.
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DR   EMBL; CH408155; EDK36486.2; -; Genomic_DNA.
DR   RefSeq; XP_001487207.1; XM_001487157.1.
DR   AlphaFoldDB; A5DBC9; -.
DR   SMR; A5DBC9; -.
DR   STRING; 4929.XP_001487207.1; -.
DR   EnsemblFungi; EDK36486; EDK36486; PGUG_00584.
DR   GeneID; 5128788; -.
DR   KEGG; pgu:PGUG_00584; -.
DR   VEuPathDB; FungiDB:PGUG_00584; -.
DR   eggNOG; KOG2834; Eukaryota.
DR   HOGENOM; CLU_017172_0_0_1; -.
DR   InParanoid; A5DBC9; -.
DR   OMA; NQFIESW; -.
DR   OrthoDB; 1106766at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd08061; MPN_NPL4; 1.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR016563; Npl4.
DR   InterPro; IPR007717; NPL4_C.
DR   InterPro; IPR024682; Npl4_Ub-like_dom.
DR   InterPro; IPR007716; NPL4_Zn-bd_put.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12710; PTHR12710; 1.
DR   Pfam; PF05021; NPL4; 1.
DR   Pfam; PF11543; UN_NPL4; 1.
DR   Pfam; PF05020; zf-NPL4; 1.
DR   PIRSF; PIRSF010052; Polyub_prc_Npl4; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; mRNA transport; Nucleus;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..564
FT                   /note="Nuclear protein localization protein 4"
FT                   /id="PRO_0000339451"
FT   DOMAIN          266..403
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   564 AA;  62885 MW;  F8B1FEA670765EF9 CRC64;
     MCYFCDFASL RVSYFIINFK FQLTQIIRFR TPSGMLRVNA TPETAFNDLL NDLGNQMGES
     DLSSFTFSDK PNDKGSSANT FHGKSVADLG LKHGDMLYVT RTATSSSPAV TASVNEPKSG
     SAVVTKPINT AGIIPIHGPT KVKQLEVDDV LDTQDGMIKR KKSNLCRHGE KGMCEYCSPL
     PSWDKGYREE NGIKHMSFHA YVNQINEQKN NRNNSTSYMS PLEEPDYNVN LNCPSGHAPY
     PKGICSKCQP PVITLQQQQF RMVDHVEFAD SGILNDFIDV WRQTGVQRFG FMFGRYEVFD
     KVPLGIKAVV EAIYEPPQAG ETDGITLLPW ENQELVLKVA EKLNLYPVGI AFTDLTDSGA
     RNGTVLCKRH KDTYFLSCLE VLMAARFQIE HPNITKHSNS GRFSSKFVTC VVSGGLEGEI
     EPRSFQVSTN AEALVRADII TGSTQPSMLY INSSQGKRYV PDVFYSKINE YGLEVKTNAK
     PAFPVDFLLV TLSDAFPLNP TPRFTNGFTI ENRDFMGNLQ DLRAAYRYIN SDPGNGSCLS
     NFHFIVYLVT LGILGDSELQ MVFD