ID   NPL4_VANPO              Reviewed;         568 AA.
AC   A7TTC4;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Nuclear protein localization protein 4;
GN   Name=NPL4; ORFNames=Kpol_242p4;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Involved in the import of nuclear-targeted proteins into the
CC       nucleus and the export of poly(A) RNA out of the nucleus. Has a role in
CC       the endoplasmic reticulum-associated degradation (ERAD) pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC       Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Localizes mainly at the nuclear periphery and
CC       the endoplasmic reticulum membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPL4 family. {ECO:0000305}.
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DR   EMBL; DS480559; EDO14481.1; -; Genomic_DNA.
DR   RefSeq; XP_001642339.1; XM_001642289.1.
DR   AlphaFoldDB; A7TTC4; -.
DR   SMR; A7TTC4; -.
DR   STRING; 436907.A7TTC4; -.
DR   EnsemblFungi; EDO14481; EDO14481; Kpol_242p4.
DR   GeneID; 5542478; -.
DR   KEGG; vpo:Kpol_242p4; -.
DR   eggNOG; KOG2834; Eukaryota.
DR   HOGENOM; CLU_017172_0_0_1; -.
DR   InParanoid; A7TTC4; -.
DR   OMA; NQFIESW; -.
DR   OrthoDB; 1106766at2759; -.
DR   PhylomeDB; A7TTC4; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd08061; MPN_NPL4; 1.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR016563; Npl4.
DR   InterPro; IPR007717; NPL4_C.
DR   InterPro; IPR007716; NPL4_Zn-bd_put.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12710; PTHR12710; 1.
DR   Pfam; PF05021; NPL4; 1.
DR   Pfam; PF05020; zf-NPL4; 1.
DR   PIRSF; PIRSF010052; Polyub_prc_Npl4; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; mRNA transport; Nucleus;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..568
FT                   /note="Nuclear protein localization protein 4"
FT                   /id="PRO_0000339456"
FT   DOMAIN          226..366
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   568 AA;  63620 MW;  83CB88C7AC8C6FE5 CRC64;
     MLLRFRSKIG MNRVSCEATD LFGDVVENWV KEVGLNVDPG TVVVGNDPGS AKEPVSNIAG
     RSVEEMGLKH GDIVYIEYSD SSGSNEGQSV PVNAVGAGSA VISELPVDVL LEKEDGLIKR
     TRSSLCKHGD KGMCEYCSPL PPWDKEYHAE NKLKHISFHS YLKKLNEATN KKSSGSSYIP
     PLSQPDYKIN KRCNNGHEPW PRGICSKCQP SAITLQQQEF RMVDHVEIQQ SDLINQFIES
     WRATGMQRFG YLYGSYEKYD STPLGVKAVV HAIYEPPQHD EQDGLTMDLE QVEEEMQKVD
     QIAMSMGLLR VGLIFSDLTD TGNGNGTVFC KRHKDSFFLS SLEIIMAAKH QLAFPNASRF
     SEQGKFSSKF VTCVVSGNLD SEIDITSYQV SIEAEALVDA KMISGSTHPS MAYINETNEE
     VYVPEIFYMK TNEYGLTVKE NAKPAFPVDY LLVSLTHGFI TEDSKNQIKF HSTGGFPWAN
     RQAMGLSQDY QELKNYLYSA ATGGDYNLLH EKISNFHLLL YIKSLEIFNE KDWSLLITSA
     ISENWEQPLI QLTTTESFNS LVLIMEMI