ID   NPL4_YARLI              Reviewed;         563 AA.
AC   Q6C619;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Nuclear protein localization protein 4;
GN   Name=NPL4; OrderedLocusNames=YALI0E13233g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the import of nuclear-targeted proteins into the
CC       nucleus and the export of poly(A) RNA out of the nucleus. Has a role in
CC       the endoplasmic reticulum-associated degradation (ERAD) pathway (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
CC       Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Localizes mainly at the nuclear periphery and
CC       the endoplasmic reticulum membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPL4 family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG79486.2; -; Genomic_DNA.
DR   RefSeq; XP_503893.2; XM_503893.2.
DR   AlphaFoldDB; Q6C619; -.
DR   SMR; Q6C619; -.
DR   STRING; 4952.CAG79486; -.
DR   EnsemblFungi; CAG79486; CAG79486; YALI0_E13233g.
DR   GeneID; 2912023; -.
DR   KEGG; yli:YALI0E13233g; -.
DR   VEuPathDB; FungiDB:YALI0_E13233g; -.
DR   HOGENOM; CLU_017172_0_0_1; -.
DR   InParanoid; Q6C619; -.
DR   OMA; KWSRTGR; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd08061; MPN_NPL4; 1.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR016563; Npl4.
DR   InterPro; IPR007717; NPL4_C.
DR   InterPro; IPR007716; NPL4_Zn-bd_put.
DR   PANTHER; PTHR12710; PTHR12710; 1.
DR   Pfam; PF05021; NPL4; 1.
DR   Pfam; PF05020; zf-NPL4; 1.
DR   PIRSF; PIRSF010052; Polyub_prc_Npl4; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Endoplasmic reticulum; Membrane; mRNA transport; Nucleus;
KW   Protein transport; Reference proteome; Translocation; Transport.
FT   CHAIN           1..563
FT                   /note="Nuclear protein localization protein 4"
FT                   /id="PRO_0000339457"
FT   DOMAIN          231..373
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   563 AA;  61600 MW;  A71BBC60A78F0645 CRC64;
     MILRFRSKKG TLRAEAQPTD LFDVAFKKLT EDLPDIDPAT ITLATSPTGK QEPASRLLGK
     TVQKLGLNHG DMLFVSYTDS APRAAVEAVT AETAPQMTAA HIRDATKQLP VDDYLEKQDG
     KIKRQLSALQ QRKFGSRGMG EDTLPVDPWD EEYLKEQKIK HMSYHAYVKK LNSQANKKNG
     GGYIAPLNVS DFGVSKSCTG AHAPWPEGIC SRCQPSAITL QSQPFRMVDH VEFAESGMIN
     SFIEPWRQSG TQRIGWMYGH YEPYELVPLG IKAVVEAIYE PAQSGEYDGI TITEITQADG
     QPQPPHIATA EACGLVPLGV IFTDLVDAGN GDGSVICKRH ADSYFLSSLE VAFAGAMQAR
     FPNKSRWSPT SEFSSKFVTA VISGNPKGEI DVSCYQVSEQ CEAMARADLI EPSINPSVLL
     VKEATKTRYV PDVFYKKNNE YGRTVLQGAN PQLPVDYMLV TLTHGFPQDP RPLFSSGLSS
     FPVENRELIG VTQSPQALGK ALDSGSAGGA VSNFHLLSYI QSMGVLSAEE FQLLAKVATE
     KKDEDVSRLV ASEGWNNLLL IIQ