NPLP1_AGRIP
ID NPLP1_AGRIP Reviewed; 476 AA.
AC C0HKY1; C0HKU3; C0HKU4; C0HKU5; C0HKU6; C0HKU7; C0HKU8;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2018, sequence version 1.
DT 25-MAY-2022, entry version 8.
DE RecName: Full=Neuropeptide-like precursor 1 {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=Neuropeptide-like precursor 1-1 {ECO:0000303|PubMed:29466015};
DE Short=NPLP1-1 {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=Neuropeptide-like precursor 1-2 {ECO:0000303|PubMed:29466015};
DE Short=NPLP1-2 {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=Neuropeptide-like precursor 1-3 {ECO:0000303|PubMed:29466015};
DE Short=NPLP1-3 {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=Neuropeptide-like precursor 1-4 {ECO:0000303|PubMed:29466015};
DE Short=NPLP1-4 {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=YRVamide {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=Extended YRVamide {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=Neuropeptide-like precursor 1-6 {ECO:0000303|PubMed:29466015};
DE Short=NPLP1-6 {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=Neuropeptide-like precursor 1-6(1-11) {ECO:0000303|PubMed:29466015};
DE Short=NPLP1-6(1-11) {ECO:0000303|PubMed:29466015};
DE Contains:
DE RecName: Full=Neuropeptide-like precursor 1-9 {ECO:0000303|PubMed:29466015};
DE Short=NPLP1-9 {ECO:0000303|PubMed:29466015};
DE Flags: Precursor;
OS Agrotis ipsilon (Black cutworm moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC Noctuidae; Noctuinae; Noctuini; Agrotis.
OX NCBI_TaxID=56364;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-48; 50-68; 71-103;
RP 106-119; 122-143; 145-157 AND 235-256, TISSUE SPECIFICITY, MASS
RP SPECTROMETRY, IDENTIFICATION BY MASS SPECTROMETRY, AND AMIDATION AT
RP VAL-133.
RX PubMed=29466015; DOI=10.1021/acs.jproteome.7b00779;
RA Diesner M., Gallot A., Binz H., Gaertner C., Vitecek S., Kahnt J.,
RA Schachtner J., Jacquin-Joly E., Gadenne C.;
RT "Mating-induced differential peptidomics of neuropeptides and protein
RT hormones in Agrotis ipsilon moths.";
RL J. Proteome Res. 17:1397-1414(2018).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Neuropeptide-like precursor 1-1: Expressed in
CC antennal lobe (AL), corpora cardiaca (CC), corpora allata (CA) and
CC gnathal ganglion (GNG) (at protein level). Expression in AL detected in
CC all animals, in GNG in most animals, expression in CC and CA in few
CC animals (at protein level). Neuropeptide-like precursor 1-2: Expressed
CC in antennal lobe (AL), corpora cardiaca (CC), corpora allata (CA) and
CC gnathal ganglion (GNG) (at protein level). Expression in AL detected in
CC all animals, in GNG in some animals, expression in CC and CA in few
CC animals (at protein level). Neuropeptide-like precursor 1-3: Not
CC expressed in antennal lobe (AL), corpora cardiaca (CC), corpora allata
CC (CA) and gnathal ganglion (GNG) (at protein level). Neuropeptide-like
CC precursor 1-4: Expressed in antennal lobe (AL) and gnathal ganglion
CC (GNG) (at protein level). Expression in AL detected in most animals, in
CC GNG in some animals (at protein level). Not expressed in CC and CA (at
CC protein level). YRVamide: Expressed in antennal lobe (AL), corpora
CC cardiaca (CC), corpora allata (CA) and gnathal ganglion (GNG) (at
CC protein level). Expression in AL and GNG detected in most animals,
CC expression in CC and CA in few animals (at protein level). Extended
CC YRVamide: Expressed in antennal lobe (AL) and gnathal ganglion (GNG)
CC (at protein level). Expression in AL detected in most animals, in GNG
CC in some animals (at protein level). Not expressed in corpora cardiaca
CC (CC) and corpora allata (CA) (at protein level). Neuropeptide-like
CC precursor 1-6: Expressed in antennal lobe (AL), corpora cardiaca (CC),
CC corpora allata (CA) and gnathal ganglion (GNG) (at protein level).
CC Expression in GNG detected in all animals, expression in AL in most
CC animals, in CC and CA in few animals (at protein level). Neuropeptide-
CC like precursor 1-6(1-11): Expressed in antennal lobe (AL) and gnathal
CC ganglion (GNG) in most animals (at protein level). Not expressed in
CC corpora cardiaca (CC) and corpora allata (CA) (at protein level).
CC Neuropeptide-like precursor 1-9: Expressed in antennal lobe (AL) and
CC gnathal ganglion (GNG) (at protein level). Expression in AL detected in
CC all animals in GNG in most (at protein level). Not expressed in corpora
CC cardiaca (CC) and corpora allata (CA) (at protein level).
CC {ECO:0000269|PubMed:29466015}.
CC -!- MASS SPECTROMETRY: [Neuropeptide-like precursor 1-1]: Mass=1642.81;
CC Method=MALDI; Note=Neuropeptide-like precursor 1-1.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [Neuropeptide-like precursor 1-2]: Mass=2082.05;
CC Method=MALDI; Note=Neuropeptide-like precursor 1-2.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [Neuropeptide-like precursor 1-3]: Mass=3725.79;
CC Method=MALDI; Note=Neuropeptide-like precursor 1-3.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [Neuropeptide-like precursor 1-4]: Mass=1554.78;
CC Method=MALDI; Note=Neuropeptide-like precursor 1-4.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [YRVamide]: Mass=1374.76; Method=MALDI;
CC Note=YRVamide.; Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [Extended YRVamide]: Mass=2464.21; Method=MALDI;
CC Note=Extended YRVamide.; Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [Neuropeptide-like precursor 1-6(1-11)]:
CC Mass=1125.68; Method=MALDI; Note=Neuropeptide-like precursor 1-6(1-
CC 11).; Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [Neuropeptide-like precursor 1-6]: Mass=1262.76;
CC Method=MALDI; Note=Neuropeptide-like precursor 1-6.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- MASS SPECTROMETRY: [Neuropeptide-like precursor 1-9]: Mass=2416.21;
CC Method=MALDI; Note=Neuropeptide-like precursor 1-9.;
CC Evidence={ECO:0000269|PubMed:29466015};
CC -!- CAUTION: Further mature peptides might exist. {ECO:0000305}.
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DR AlphaFoldDB; C0HKY1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Secreted; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT PEPTIDE 35..48
FT /note="Neuropeptide-like precursor 1-1"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444250"
FT PEPTIDE 50..68
FT /note="Neuropeptide-like precursor 1-2"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444251"
FT PEPTIDE 71..103
FT /note="Neuropeptide-like precursor 1-3"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444252"
FT PEPTIDE 106..119
FT /note="Neuropeptide-like precursor 1-4"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444253"
FT PEPTIDE 122..143
FT /note="Extended YRVamide"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444255"
FT PEPTIDE 122..133
FT /note="YRVamide"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444254"
FT PEPTIDE 146..157
FT /note="Neuropeptide-like precursor 1-6"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444257"
FT PEPTIDE 146..156
FT /note="Neuropeptide-like precursor 1-6(1-11)"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444256"
FT PROPEP 160..232
FT /evidence="ECO:0000305"
FT /id="PRO_0000444258"
FT PEPTIDE 235..256
FT /note="Neuropeptide-like precursor 1-9"
FT /evidence="ECO:0000269|PubMed:29466015"
FT /id="PRO_0000444259"
FT PROPEP 259..476
FT /evidence="ECO:0000305"
FT /id="PRO_0000444260"
FT REGION 275..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 360..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..297
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 133
FT /note="Valine amide"
FT /evidence="ECO:0000269|PubMed:29466015"
SQ SEQUENCE 476 AA; 54706 MW; F628C7300D8FA9E7 CRC64;
MNDAGASIGR HRGCLLLFVA LAVAFSSYVE QVESMPAEPV SQWPTFPRRN IAALARDGYL
RNSASRAYKR GISTLAKNGL LPTYRSPYVE TDKEDQNQDE SQEKRNMASI ARLRSYAAMK
RNIQALARDG YRVGRGQYNP SNDKRNIAAL ARNGLLHKKD EATENEYYFP FYQNPIAPLS
EIDHPLDVNE MYDFQQSMNP DMFPSMSQVY KRSLYEPYYD YYSPKDYDNS YFKRSSAGSP
VHGLYRPNYL EPNTRTKRYV MPYPDILEGD EMIEQNDIDG EKRSVDDDDD DDDDDGEVHE
NFQKRHIGSL ARLGLLPSFR YSGGRYSRSG RARLLLPSQE LYRKHSPDEN FGIREYLSSP
EVESPVDPDD ADIPPPPVPA HSHPTGRLLH RPLSNDLPHT SPLPLPPIAP TNYADTFTKN
RWQSYTKETP KFYYFRSLKV PYHTSGKRYL LLPAVDNILL RKGYRNSSLP SRRKNQ
