NPLP3_DROME
ID NPLP3_DROME Reviewed; 90 AA.
AC Q9VV28;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Neuropeptide-like 3;
DE Contains:
DE RecName: Full=SHA-peptide;
DE Contains:
DE RecName: Full=VVI-amide peptide;
DE Flags: Precursor;
GN Name=Nplp3; ORFNames=CG13061;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PROTEIN SEQUENCE OF 55-66 AND 80-89, AND AMIDATION AT ILE-89.
RC TISSUE=Larva;
RX PubMed=12171930; DOI=10.1074/jbc.m206257200;
RA Baggerman G., Cerstiaens A., De Loof A., Schoofs L.;
RT "Peptidomics of the larval Drosophila melanogaster central nervous
RT system.";
RL J. Biol. Chem. 277:40368-40374(2002).
RN [5]
RP PROTEIN SEQUENCE OF 55-66 AND 80-89.
RC TISSUE=CNS;
RX PubMed=14690519; DOI=10.1046/j.1471-4159.2003.02161.x;
RA Verleyen P., Baggerman G., Wiehart U., Schoeters E., Van Lommel A.,
RA De Loof A., Schoofs L.;
RT "Expression of a novel neuropeptide, NVGTLARDFQLPIPNamide, in the larval
RT and adult brain of Drosophila melanogaster.";
RL J. Neurochem. 88:311-319(2004).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014296; AAF49494.1; -; Genomic_DNA.
DR EMBL; AY113570; AAM29575.1; -; mRNA.
DR RefSeq; NP_652710.1; NM_144453.3.
DR AlphaFoldDB; Q9VV28; -.
DR STRING; 7227.FBpp0075128; -.
DR PaxDb; Q9VV28; -.
DR DNASU; 59235; -.
DR EnsemblMetazoa; FBtr0075369; FBpp0075128; FBgn0042201.
DR GeneID; 59235; -.
DR KEGG; dme:Dmel_CG13061; -.
DR CTD; 59235; -.
DR FlyBase; FBgn0042201; Nplp3.
DR VEuPathDB; VectorBase:FBgn0042201; -.
DR eggNOG; ENOG502TBFF; Eukaryota.
DR HOGENOM; CLU_2443129_0_0_1; -.
DR InParanoid; Q9VV28; -.
DR OMA; KMFKLCV; -.
DR OrthoDB; 1625002at2759; -.
DR PhylomeDB; Q9VV28; -.
DR BioGRID-ORCS; 59235; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 59235; -.
DR PRO; PR:Q9VV28; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0042201; Expressed in capitellum (Drosophila) and 12 other tissues.
DR ExpressionAtlas; Q9VV28; baseline and differential.
DR Genevisible; Q9VV28; DM.
DR GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR GO; GO:0005184; F:neuropeptide hormone activity; NAS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; NAS:UniProtKB.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT PROPEP 17..54
FT /id="PRO_0000021845"
FT PEPTIDE 55..66
FT /note="SHA-peptide"
FT /id="PRO_0000021846"
FT PROPEP 67..79
FT /id="PRO_0000021847"
FT PEPTIDE 80..89
FT /note="VVI-amide peptide"
FT /id="PRO_0000021848"
FT MOD_RES 89
FT /note="Isoleucine amide"
FT /evidence="ECO:0000269|PubMed:12171930"
SQ SEQUENCE 90 AA; 8688 MW; 3C676E3C03A1D61B CRC64;
MFKLCVFVAL LSLAAAAPAP APAPAPAPGL IGPGIVAPGI WGPTVVGSPL LAPQVVSVVP
GAISHAAITQ VHPSPLLIKS VHGLGPVVIG
