ID   NPLP4_DROME             Reviewed;          64 AA.
AC   Q9VQ66;
DT   17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Neuropeptide-like 4;
DE   AltName: Full=YSY peptide;
DE   Flags: Precursor;
GN   Name=Nplp4; ORFNames=CG15361;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   PROTEIN SEQUENCE OF 41-62.
RC   TISSUE=Larva;
RX   PubMed=12171930; DOI=10.1074/jbc.m206257200;
RA   Baggerman G., Cerstiaens A., De Loof A., Schoofs L.;
RT   "Peptidomics of the larval Drosophila melanogaster central nervous
RT   system.";
RL   J. Biol. Chem. 277:40368-40374(2002).
RN   [4]
RP   PROTEIN SEQUENCE OF 41-62.
RC   TISSUE=CNS;
RX   PubMed=14690519; DOI=10.1046/j.1471-4159.2003.02161.x;
RA   Verleyen P., Baggerman G., Wiehart U., Schoeters E., Van Lommel A.,
RA   De Loof A., Schoofs L.;
RT   "Expression of a novel neuropeptide, NVGTLARDFQLPIPNamide, in the larval
RT   and adult brain of Drosophila melanogaster.";
RL   J. Neurochem. 88:311-319(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; AE014134; AAF51315.1; -; Genomic_DNA.
DR   RefSeq; NP_001259893.1; NM_001272964.2.
DR   RefSeq; NP_652352.1; NM_144095.3.
DR   AlphaFoldDB; Q9VQ66; -.
DR   BioGRID; 72580; 1.
DR   DIP; DIP-22218N; -.
DR   STRING; 7227.FBpp0077493; -.
DR   PaxDb; Q9VQ66; -.
DR   DNASU; 50190; -.
DR   EnsemblMetazoa; FBtr0077817; FBpp0077493; FBgn0040717.
DR   EnsemblMetazoa; FBtr0334759; FBpp0306800; FBgn0040717.
DR   GeneID; 50190; -.
DR   KEGG; dme:Dmel_CG15361; -.
DR   CTD; 50190; -.
DR   FlyBase; FBgn0040717; Nplp4.
DR   VEuPathDB; VectorBase:FBgn0040717; -.
DR   eggNOG; ENOG502T8QV; Eukaryota.
DR   HOGENOM; CLU_2869908_0_0_1; -.
DR   OMA; YYYGASP; -.
DR   SignaLink; Q9VQ66; -.
DR   BioGRID-ORCS; 50190; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 50190; -.
DR   PRO; PR:Q9VQ66; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0040717; Expressed in larva and 12 other tissues.
DR   ExpressionAtlas; Q9VQ66; baseline and differential.
DR   Genevisible; Q9VQ66; DM.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0005184; F:neuropeptide hormone activity; NAS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; NAS:UniProtKB.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Neuropeptide; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..40
FT                   /id="PRO_0000021853"
FT   PEPTIDE         41..62
FT                   /note="Neuropeptide-like 4"
FT                   /id="PRO_0000021854"
FT   PROPEP          63..64
FT                   /id="PRO_0000021855"
SQ   SEQUENCE   64 AA;  6798 MW;  2A33ECC15693F623 CRC64;
     MFKLLVVVFA ALFAAALAVP APVARANPAP IPIASPEPAP QYYYGASPYA YSGGYYDSPY
     SYYG