NPR1_MALHU
ID NPR1_MALHU Reviewed; 586 AA.
AC E7BQV0; G8XUV9;
DT 03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT 03-JUL-2019, sequence version 2.
DT 25-MAY-2022, entry version 36.
DE RecName: Full=BTB/POZ domain and ankyrin repeat-containing protein NPR1 {ECO:0000305};
DE Short=MhNPR1 {ECO:0000303|PubMed:21973266};
DE AltName: Full=NPR1 homolog {ECO:0000303|PubMed:21973266};
GN Name=NPR1 {ECO:0000303|PubMed:21973266};
OS Malus hupehensis (Chinese crab apple).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Maleae; Malus.
OX NCBI_TaxID=106556;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=21973266; DOI=10.1111/j.1438-8677.2011.00483.x;
RA Zhang J.Y., Qiao Y.S., Lv D., Gao Z.H., Qu S.C., Zhang Z.;
RT "Malus hupehensis NPR1 induces pathogenesis-related protein gene expression
RT in transgenic tobacco.";
RL Plant Biol. 1:46-56(2012).
RN [2]
RP FUNCTION.
RX PubMed=22539187; DOI=10.1007/s11033-012-1655-3;
RA Chen X.K., Zhang J.Y., Zhang Z., Du X.L., Du B.B., Qu S.C.;
RT "Overexpressing MhNPR1 in transgenic Fuji apples enhances resistance to
RT apple powdery mildew.";
RL Mol. Biol. Rep. 39:8083-8089(2012).
RN [3]
RP FUNCTION, AND INDUCTION.
RX PubMed=24407603; DOI=10.1007/s11033-013-3001-9;
RA Zhang J.Y., Qu S.C., Qiao Y.S., Zhang Z., Guo Z.R.;
RT "Overexpression of the Malus hupehensis MhNPR1 gene increased tolerance to
RT salt and osmotic stress in transgenic tobacco.";
RL Mol. Biol. Rep. 41:1553-1561(2014).
CC -!- FUNCTION: Probable component of the salicylic acid (SA) defense
CC signaling pathway and pathogen-induced systemic acquired resistance
CC (SAR) (Probable). May be involved in disease resistance against fungal
CC pathogens (Probable). May be involved in tolerance to salt and osmotic
CC stresses (PubMed:24407603). {ECO:0000269|PubMed:24407603,
CC ECO:0000305|PubMed:21973266, ECO:0000305|PubMed:22539187}.
CC -!- TISSUE SPECIFICITY: Highly expressed in leaves (PubMed:21973266).
CC Expressed at low levels in roots and stems (PubMed:21973266).
CC {ECO:0000269|PubMed:21973266}.
CC -!- INDUCTION: Induced by salicylic acid (SA) in roots, stems and leaves
CC (PubMed:21973266). Induced by jasmonate in roots (PubMed:21973266).
CC Induced by ethylene in roots and leaves (PubMed:21973266). Induced by
CC salt stress, osmotic shock, cold stress and abscisic acid (ABA)
CC (PubMed:24407603). {ECO:0000269|PubMed:21973266,
CC ECO:0000269|PubMed:24407603}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FJ598141; ACU78081.1; -; mRNA.
DR EMBL; GU183100; ADP95762.1; -; Genomic_DNA.
DR AlphaFoldDB; E7BQV0; -.
DR SMR; E7BQV0; -.
DR GO; GO:0006952; P:defense response; TAS:UniProtKB.
DR GO; GO:2000022; P:regulation of jasmonic acid mediated signaling pathway; IEA:InterPro.
DR GO; GO:2000031; P:regulation of salicylic acid mediated signaling pathway; IEA:InterPro.
DR GO; GO:0009651; P:response to salt stress; IMP:UniProtKB.
DR GO; GO:0009414; P:response to water deprivation; IMP:UniProtKB.
DR GO; GO:0009862; P:systemic acquired resistance, salicylic acid mediated signaling pathway; IEA:InterPro.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR044292; NPR.
DR InterPro; IPR021094; NPR1/NIM1-like_C.
DR InterPro; IPR024228; NPR_central_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR46475; PTHR46475; 1.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF11900; DUF3420; 1.
DR Pfam; PF12313; NPR1_like_C; 1.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; Plant defense; Repeat; Stress response.
FT CHAIN 1..586
FT /note="BTB/POZ domain and ankyrin repeat-containing protein
FT NPR1"
FT /id="PRO_0000447479"
FT DOMAIN 63..139
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REPEAT 266..296
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 298..325
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REPEAT 329..358
FT /note="ANK 3"
FT /evidence="ECO:0000255"
FT REGION 561..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 93
FT /note="K -> R (in Ref. 1; ACU78081)"
FT /evidence="ECO:0000305"
FT CONFLICT 163..166
FT /note="VELM -> EELT (in Ref. 1; ADP95762)"
FT CONFLICT 226
FT /note="D -> N (in Ref. 1; ACU78081)"
FT /evidence="ECO:0000305"
FT CONFLICT 258
FT /note="P -> S (in Ref. 1; ACU78081)"
FT /evidence="ECO:0000305"
FT CONFLICT 285
FT /note="L -> P (in Ref. 1; ACU78081)"
FT /evidence="ECO:0000305"
FT CONFLICT 333
FT /note="A -> V (in Ref. 1; ACU78081)"
FT /evidence="ECO:0000305"
FT CONFLICT 383
FT /note="T -> A (in Ref. 1; ACU78081)"
FT /evidence="ECO:0000305"
FT CONFLICT 485
FT /note="N -> S (in Ref. 1; ACU78081)"
FT /evidence="ECO:0000305"
FT CONFLICT 566
FT /note="S -> P (in Ref. 1; ACU78081)"
FT /evidence="ECO:0000305"
FT CONFLICT 575
FT /note="E -> K (in Ref. 1; ACU78081)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 586 AA; 65083 MW; 11C480E7AA714DD3 CRC64;
MAHSAEPSSS LSFTSSPHLS NGSISHNLSC SGSESVPSLE VISLSKLSSS LEQLLIDPGC
DYSDADIVVE GIPVGVHRCI LASRSGFFRE LFKREKGSSG KEDRPKYCMS DFLPYGDVGY
EAFLVFLSYV YTGKLKPSPV EVSTCVHNVC AHDACRPAIN FVVELMYAAS IFQMPDLVSI
FERRLLNFVG KALSDNVVPI LLVAFHCQLN QLIDQCVDRV ARSDIDDISL EKGLPDEVVK
KIKILRRNYQ QDSDPNLPPA DPLHEKRIRR IHKALDSDDV ELVKLLLTES NITLDEANAL
HYAAAYCDPK VVTEVLALGL ADVNLRNSRG YTALHIAVMR KEPSIIVLLL TKGARASELT
SDGQSAVSIC RRLTRPKDYH SKTEQGQEAN KDRICIDVLE REMRRNPMAG DASISSQIMP
DDLHMELLNL ENRVALARLF FPAEAKLAMV IAHAETSEFA APSSSKGSSG NLMEVDLNET
PTVQNKRLHS RLEALMKTVR LGRCYFPHCS EVLDKFIDDD LPHLFYLEPG SSDEQKVKRR
RFMELKEEVQ KAFDKDKAEC NLSGLSSSSS TTSPEKIGAN QKVREP
