ID   NPR2_ORYSJ              Reviewed;         635 AA.
AC   Q0JJ01; Q5D0W7; Q5ZAN8;
DT   07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=BTB/POZ domain and ankyrin repeat-containing protein NPR2 {ECO:0000305};
DE            Short=OsNPR2 {ECO:0000303|PubMed:17309686};
DE   AltName: Full=NPR1 homolog 2 {ECO:0000305};
DE            Short=OsNH2 {ECO:0000303|PubMed:15986920};
GN   Name=NPR2 {ECO:0000303|PubMed:17309686};
GN   Synonyms=NH2 {ECO:0000303|PubMed:15986920};
GN   OrderedLocusNames=Os01g0767900 {ECO:0000312|EMBL:BAF06277.1},
GN   LOC_Os01g56200 {ECO:0000305};
GN   ORFNames=B1143G03.10 {ECO:0000312|EMBL:BAD53329.1},
GN   OSJNBb0053G03.24 {ECO:0000312|EMBL:BAD53355.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND FUNCTION.
RX   PubMed=17309686; DOI=10.1111/j.1467-7652.2007.00243.x;
RA   Yuan Y., Zhong S., Li Q., Zhu Z., Lou Y., Wang L., Wang J., Wang M., Li Q.,
RA   Yang D., He Z.;
RT   "Functional analysis of rice NPR1-like genes reveals that OsNPR1/NH1 is the
RT   rice orthologue conferring disease resistance with enhanced herbivore
RT   susceptibility.";
RL   Plant Biotechnol. J. 5:313-324(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Dongjin;
RA   Moon S.-J., Shin D., Kim B.-G., Park S.R., Byun M.-O.;
RT   "Oryza sativa japonica group cultivar Dongjin putative NPR1-like protein 1
RT   (NPR1) mRNA.";
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447438; DOI=10.1038/nature01184;
RA   Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA   Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA   Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA   Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA   Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA   Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA   Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA   Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA   Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA   Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA   Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA   Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA   Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT   "The genome sequence and structure of rice chromosome 1.";
RL   Nature 420:312-316(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [6]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 430-635, AND INTERACTION WITH NRR.
RX   PubMed=15986920; DOI=10.1094/mpmi-18-0511;
RA   Chern M., Fitzgerald H.A., Canlas P.E., Navarre D.A., Ronald P.C.;
RT   "Overexpression of a rice NPR1 homolog leads to constitutive activation of
RT   defense response and hypersensitivity to light.";
RL   Mol. Plant Microbe Interact. 18:511-520(2005).
RN   [9]
RP   INTERACTION WITH TGAL1 AND TGAL11.
RX   PubMed=24919709; DOI=10.1186/1471-2164-15-461;
RA   Chern M., Bai W., Ruan D., Oh T., Chen X., Ronald P.C.;
RT   "Interaction specificity and coexpression of rice NPR1 homologs 1 and 3
RT   (NH1 and NH3), TGA transcription factors and negative regulator of
RT   resistance (NRR) proteins.";
RL   BMC Genomics 15:461-461(2014).
CC   -!- FUNCTION: Does not seem to be involved in defense response against the
CC       bacterial blight disease caused by Xanthomonas oryzae pv. oryzae (Xoo).
CC       Over-expression of NPR2/NH2 does not confer disease resistance to Xoo.
CC       {ECO:0000269|PubMed:17309686}.
CC   -!- SUBUNIT: Interacts with NRR (PubMed:15986920). Interacts with TGAL1 and
CC       TGAL11 (PubMed:24919709). {ECO:0000269|PubMed:15986920,
CC       ECO:0000269|PubMed:24919709}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD53329.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAD53355.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; DQ450949; ABE11615.1; -; mRNA.
DR   EMBL; DQ450950; ABE11616.1; -; Genomic_DNA.
DR   EMBL; HM991166; AEF30409.1; -; mRNA.
DR   EMBL; AP003371; BAD53329.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AP003377; BAD53355.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AP008207; BAF06277.1; -; Genomic_DNA.
DR   EMBL; AP014957; BAS74525.1; -; Genomic_DNA.
DR   EMBL; AK067198; BAG90312.1; -; mRNA.
DR   EMBL; AY923984; AAX18701.1; -; mRNA.
DR   RefSeq; XP_015620897.1; XM_015765411.1.
DR   AlphaFoldDB; Q0JJ01; -.
DR   SMR; Q0JJ01; -.
DR   STRING; 4530.OS01T0767900-01; -.
DR   PaxDb; Q0JJ01; -.
DR   PRIDE; Q0JJ01; -.
DR   EnsemblPlants; Os01t0767900-01; Os01t0767900-01; Os01g0767900.
DR   GeneID; 4325503; -.
DR   Gramene; Os01t0767900-01; Os01t0767900-01; Os01g0767900.
DR   KEGG; osa:4325503; -.
DR   eggNOG; KOG0504; Eukaryota.
DR   HOGENOM; CLU_034895_1_0_1; -.
DR   InParanoid; Q0JJ01; -.
DR   OMA; GRPRYKM; -.
DR   OrthoDB; 631377at2759; -.
DR   PlantReactome; R-OSA-6788019; Salicylic acid signaling.
DR   Proteomes; UP000000763; Chromosome 1.
DR   Proteomes; UP000059680; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0050832; P:defense response to fungus; IBA:GO_Central.
DR   GO; GO:2000022; P:regulation of jasmonic acid mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:2000031; P:regulation of salicylic acid mediated signaling pathway; IEA:InterPro.
DR   GO; GO:0009862; P:systemic acquired resistance, salicylic acid mediated signaling pathway; IEA:InterPro.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR044292; NPR.
DR   InterPro; IPR021094; NPR1/NIM1-like_C.
DR   InterPro; IPR024228; NPR_central_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR46475; PTHR46475; 1.
DR   Pfam; PF13637; Ank_4; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF11900; DUF3420; 1.
DR   Pfam; PF12313; NPR1_like_C; 1.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   1: Evidence at protein level;
KW   ANK repeat; Plant defense; Reference proteome; Repeat.
FT   CHAIN           1..635
FT                   /note="BTB/POZ domain and ankyrin repeat-containing protein
FT                   NPR2"
FT                   /id="PRO_0000437001"
FT   DOMAIN          97..191
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REPEAT          317..347
FT                   /note="ANK 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          349..376
FT                   /note="ANK 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          380..409
FT                   /note="ANK 3"
FT                   /evidence="ECO:0000255"
FT   REGION          138..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   635 AA;  68495 MW;  3591FF56EDA1AF6A CRC64;
     MPARSAVVVI AMEPSSSITI ASSSSYLSNG SSPCSVSLAP PGAGAVAAQA APVAAGEGGG
     GGGGGGGGGS SSVEVVSLNR LSANLERLLL DSDLDCSDAD VDVADGGPPV PVHRCILAAR
     STFFYNLFAA RGRGGDGAAG GGGGGGGGGG ERTGGRPRYK MEELVPGGRV GRDAFLSLLG
     YLYTGKLRPA PDDVVSCADP MCPHDSCPPA IRFNVEQMYA AWAFKITELI SLFQRRLLNF
     VDKTLVEDVL PILQVAFHSE LTPVLEKCIR RIARSNLDNV SLDKELPPEV AVQIKEIRQK
     SQPNEGDTVI SDPVHEKRVR RIHRALDSDD VELVKLLLNE SEITLDDANA LHYAAAYCDS
     KVVSELLDLR LANLNLKNSR GYTALHLAAM RREPAIIMCL LNKGAAVSQL TADGQSAMSI
     CRRLTRMKDY NTKMEQGQES NKDRLCIDIL DREMIRKPMA VEDSVTSPLL ADDLHMKLLY
     LENRVAFARL FFPAEAKVAM QIAQADTTPE FGIVPAASTS GKLKEVDLNE TPVTQNKRLR
     SRVDALMKTV ELGRRYFPNC SQVLDKFLED DLPDSPDALD LQNGTSDEQN VKRMRFCELK
     EDVRKAFSKD RADNSMFSIL SSSSSSSPPP KVAKK