ID   NPR2_SCHPO              Reviewed;         409 AA.
AC   O42857;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Nitrogen permease regulator 2 homolog;
GN   ORFNames=SPAC23H3.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Post-transcriptional regulator of nitrogen
CC       permeases (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the NPR2 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB16240.1; -; Genomic_DNA.
DR   PIR; T38296; T38296.
DR   RefSeq; NP_593793.1; NM_001019222.2.
DR   AlphaFoldDB; O42857; -.
DR   SMR; O42857; -.
DR   BioGRID; 278331; 14.
DR   STRING; 4896.SPAC23H3.03c.1; -.
DR   MaxQB; O42857; -.
DR   PaxDb; O42857; -.
DR   PRIDE; O42857; -.
DR   EnsemblFungi; SPAC23H3.03c.1; SPAC23H3.03c.1:pep; SPAC23H3.03c.
DR   GeneID; 2541840; -.
DR   KEGG; spo:SPAC23H3.03c; -.
DR   PomBase; SPAC23H3.03c; -.
DR   VEuPathDB; FungiDB:SPAC23H3.03c; -.
DR   eggNOG; KOG3789; Eukaryota.
DR   HOGENOM; CLU_014995_3_1_1; -.
DR   InParanoid; O42857; -.
DR   OMA; YASMTHG; -.
DR   PhylomeDB; O42857; -.
DR   PRO; PR:O42857; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IBA:GO_Central.
DR   GO; GO:1990130; C:GATOR1 complex; IMP:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005774; C:vacuolar membrane; EXP:PomBase.
DR   GO; GO:0005096; F:GTPase activator activity; EXP:PomBase.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IMP:PomBase.
DR   GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR   InterPro; IPR009348; NPR2.
DR   PANTHER; PTHR12991; PTHR12991; 1.
DR   Pfam; PF06218; NPR2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..409
FT                   /note="Nitrogen permease regulator 2 homolog"
FT                   /id="PRO_0000339459"
SQ   SEQUENCE   409 AA;  47029 MW;  C4A48F98A2403165 CRC64;
     MEYSEEGWMD QADSFPPRLL AIFFALFDPL QGPIVACEAP AGSVTNVDGG KNCLLPFETI
     SDYVIPKREL CNKTITVCTN HYQVIGHPIS IIGSNYERNA LIFNMCMIFH EEEDSACYIP
     LVKRLARNLE VLEKQIHYIS DLNKRPVIFS VIEQILEDMN NFCECMIQLD DQNSINIKLF
     PVFPSPPTVK SFHVPILTAQ LDLLMDKNWD MTVQKVYPFI NGINSVQRIA ELANVSYRSC
     QKCMEHFLYY GCLIIADIFQ FHNIYAMTTN APNLLQDPDF QRECTAYVST NSSNAKNVTF
     ATIFKLYCSL RQGLRVKDWM NENKEIFKGL DVRRLISFGT IKGLIYRVHK YPYLERRTMR
     NNLTEEEKKL LGLLDGKHHF DELCVTLKKS PKVVNEMIAG LGDACFIYV