NPR3_ASPFU
ID NPR3_ASPFU Reviewed; 843 AA.
AC Q4WTC7;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Nitrogen permease regulator 3;
DE AltName: Full=Required for meiotic nuclear division protein 11;
DE Flags: Precursor;
GN Name=npr3; Synonyms=rmd11; ORFNames=AFUA_1G09760;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC amino acid starvation. Required for meiotic nuclear division (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR EMBL; AAHF01000004; EAL90305.2; -; Genomic_DNA.
DR RefSeq; XP_752343.2; XM_747250.2.
DR AlphaFoldDB; Q4WTC7; -.
DR STRING; 746128.CADAFUBP00000903; -.
DR EnsemblFungi; EAL90305; EAL90305; AFUA_1G09760.
DR GeneID; 3510523; -.
DR KEGG; afm:AFUA_1G09760; -.
DR VEuPathDB; FungiDB:Afu1g09760; -.
DR eggNOG; KOG3830; Eukaryota.
DR HOGENOM; CLU_014314_1_0_1; -.
DR InParanoid; Q4WTC7; -.
DR OMA; ARTDYVW; -.
DR OrthoDB; 628619at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IBA:GO_Central.
DR GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR GO; GO:0038202; P:TORC1 signaling; IBA:GO_Central.
DR InterPro; IPR005365; Npr3.
DR PANTHER; PTHR13153; PTHR13153; 1.
DR Pfam; PF03666; NPR3; 1.
PE 3: Inferred from homology;
KW Meiosis; Reference proteome; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..843
FT /note="Nitrogen permease regulator 3"
FT /id="PRO_0000301792"
FT REGION 30..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..763
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 843 AA; 92726 MW; 7560F505C6CF5B58 CRC64;
MSSIARPPDP CLVAIILIVR SRAGPRLVFH YPPNPLSENG LRPARKERRT SRSKNGQDYK
SNESSSSEES GSSSDDDEDE HQRQLQSQSQ SQSHLSGSVV SGRRSSNFGL DDHVAMSVSP
GGDSQRAGSM GSGSGRTSFR KRGGNSDVEE DSGAASDRQE DGSGGAGGPY RPPWESLLGL
PADVWEKLLS PSPAWHKRRF EVGINDLAFI GWPVFVREDG TWRKQRRKKK KKRRADWEGG
ELGHNENAED APDDEDGDAG GNASGGGGLM AASTETLSPK QVTLSEAKRG SGSSGKAARS
LVDCLDGDDK DSMTMFNVVF VLDPPLLEYS MRTKEVYDNI IKKFAKALKW EQARTDYVWR
EAQHISHLKE KAKERRTSLN TLYTELITQS SLARAIYTVH TSISASKIAS VPLSPDVSIS
LQIPPLTSTP YLPGPTDKAY PGLWLTTADS VTPVEDPTAD EYTAPHQVLA KHFALLLLDN
EAAILRDVEA SGGALAPALA HYLRCSKPTK SFAQISASSG IPLSTIQMLA SHLVYWRRAR
AIPPIHQRDT YIVSPNCDLS KLEVATAAYQ AAFPTLPSLP KMLSALSGTP RPYGSFIPSK
DHKETYFAIL AWLLRGGWVT QLRSFARVKV TPEIKMAVEV ALRREEVDKY LRKGRSLEAQ
KSTDGENGNE EDENDDASSS SSSSLASQGS GEETPMPGRY QQESNPRLSH SMLDRNTSLR
TSSLILFPHR ASPLESRWLE QIVSRFPEHP RSAGRHRRGE GSNAGGGEID PEYAALSTPM
KDLWPTYIKY FNGLDALEKI PVREGLKRKF VWQVLTRLGL VTSQQSSIEL DPREQVLVSV
RHW
