ID   NPR3_ASPNC              Reviewed;         869 AA.
AC   A2QQ79;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=npr3; Synonyms=rmd11; ORFNames=An08g01560;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAK39836.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AM270160; CAK39836.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; A2QQ79; -.
DR   PaxDb; A2QQ79; -.
DR   EnsemblFungi; CAK39836; CAK39836; An08g01560.
DR   Proteomes; UP000006706; Chromosome 8R.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..869
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301793"
FT   REGION          31..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          662..702
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          842..869
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        119..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..175
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        239..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        662..677
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        678..692
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   869 AA;  95390 MW;  3D7F43A2EDB0EE4E CRC64;
     MSSIARPPDP CLVAIILIVR SRAGPRFVFH YPPNPLSENG LRGAPKARRP SRKNSKSNES
     SSSEDSSSTS SEDEDEAPIT ATAAAPATTG TATQPANATQ NASHVAGSHP VAGRRSSNFG
     VVDDTTISGS PGGESQRAGS VGSGRGLMMR KRGTNSDAEE DAGAASDRQE DEAGPFRPPW
     ESLLGLPADV WEKLLSPSRS WHKRRFEVGI NDLAFVGWPV FVREDGTWRK QRRKKRKPRA
     TWEGGELGHN ETPGDGDGDG EGDEAGTEDD SPDRGTELIA ASTETLSPKQ MATTDSQRAS
     MISVRSFRTL SEALDPDDKD CMTMFNVVFV LDPPLLEYSM RLREIYDNII KKFSKALKWE
     QARTDYVWKE AQHISHIKEK AKEKRMSVNS LYSELISQSS LARAICTVFT SISASKIASV
     SLSPDVSISL QIPPLTSTPW LPGPTDKAYP GLWLTTADSV TPVDDPTADE NTAPHQVLAK
     HFALLLLDNE ASILKDVEAS GGALAPALAH YIRCSKPTKS FAQISVSSGI PLSTIQMLAS
     HLVYWRRARA IPPLHQRDTY IVSPNCDLSK LEVATAAYQA AFPTLPSLPK MLSAMSGTPR
     PYGSFIPSKD HKDTYFAILA WLLRGGWVTQ LRAFARVKIS PEIKMAVETA LRQEEVDKYL
     SKRGSASDTE IREDLDDASS SSSSSLGSNG SGDETPMPGR YKRNNELDLS HSLLDQNTSL
     KTSSLILYPH RASPLESRWL GEVMARFPEL QGDVPDGDLE YAGLRTSLKK YWPTFIKYFN
     GYDALEKIPV RESLKRKLVW QILMRLGLVT GQQSSIQLDP REQILKTVQF FTKTIHNFEI
     NKTISPNPAS SHVMTPRHTD GRNGTTPTN