ID   NPR3_EMENI              Reviewed;         816 AA.
AC   C8VSE7; Q5BDU1;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=npr3; Synonyms=rmd11; ORFNames=AN10171, AN1289;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA65882.1; Type=Erroneous gene model prediction; Note=The predicted gene AN1289 has been split into 2 genes: AN10176 and AN10171.; Evidence={ECO:0000305};
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DR   EMBL; AACD01000017; EAA65882.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001308; CBF87783.1; -; Genomic_DNA.
DR   AlphaFoldDB; C8VSE7; -.
DR   STRING; 162425.CADANIAP00001329; -.
DR   EnsemblFungi; CBF87783; CBF87783; ANIA_10171.
DR   EnsemblFungi; EAA65882; EAA65882; AN1289.2.
DR   VEuPathDB; FungiDB:AN10171; -.
DR   eggNOG; KOG3830; Eukaryota.
DR   HOGENOM; CLU_014314_1_0_1; -.
DR   InParanoid; C8VSE7; -.
DR   OMA; ARTDYVW; -.
DR   OrthoDB; 628619at2759; -.
DR   Proteomes; UP000000560; Chromosome VIII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..816
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301800"
FT   REGION          26..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          213..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          632..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..159
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..242
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        262..282
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        632..657
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        658..674
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   816 AA;  90513 MW;  88797DAEE7EEF16D CRC64;
     MSSIARPPDP CLVAVVLIAR SRAGPRFVFH YPPRPLADNA LRPPKARRTS RSRSRQNSKG
     NDSTSSDDSH SSSDEDEEEA PSQNLNNSNN SNNNSYIAGS RRSSNFGLDD SNTLSENQRP
     GSISSSRAYL RKRGANSDAE TDSGVGSDRQ EDGSRESDGP NRVPWESILG LPVDVWEKLL
     SPSRSWHKRR FELGINDLAF VGWPVFVRED GNWRKQRRKK KKKQRAEWES GELGHNDATE
     DSQDDGNDAV AASTETLSPF SALHPISQRP SVPNSRSSQM SSEPLDADDK DMMTMFNVVF
     VLDPPLLEYS MRVREIYDNV IKKFSKALKW EQSRTNYVWR ECQHILNIKE KAKEKRSSLN
     SLYADIISQS SLARAIRTLY TSISASKIAS VTLSPDVSIS LQIPPLTSTP YLPGPTDQAY
     PGLWLTTADS ISPADDPMTD DNSAPHQVLA KHFALLLLDN EATIIKDVEA AGGALAPPLV
     HYIRCSSPTK SFVQISQISG MPLPTIQFLA SHLVYWRRAR AIPPLHQRDT YIVSPNCDLS
     KLEVASAAYK VAFPTLPSLP KMLSALSGTP RPYGNFIPSK DHKATYFLIL AWLLRGGWVT
     QLRSFARVKV SPEIKMAVEL AIRREEVDKY LSKGKPPVAT SDKEDSVNDE RTEGSDFDDA
     SSSSSSSLAS HGSGDATPMP NRFRADTGVD LTHSLLDQTA SLKTSSLILL PHKVSPLESR
     WLDEIVARFP DNAPDFVGNT TEVDSATPIP AKSLKEVWPT YLKYFNGYDA LEKIPVREGL
     KRKLVSQVLT RLGLVTGQSS TELDPREQVL VSFRHW