ID   NPR3_PICST              Reviewed;         721 AA.
AC   A3LYV8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=NPR3; Synonyms=RMD11; ORFNames=PICST_63276;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR   EMBL; CP000501; ABN68047.2; -; Genomic_DNA.
DR   RefSeq; XP_001386076.2; XM_001386039.1.
DR   AlphaFoldDB; A3LYV8; -.
DR   STRING; 4924.XP_001386076.2; -.
DR   EnsemblFungi; ABN68047; ABN68047; PICST_63276.
DR   GeneID; 4840642; -.
DR   KEGG; pic:PICST_63276; -.
DR   eggNOG; ENOG502QW35; Eukaryota.
DR   HOGENOM; CLU_014314_0_0_1; -.
DR   InParanoid; A3LYV8; -.
DR   OMA; CLPQKVH; -.
DR   OrthoDB; 628619at2759; -.
DR   Proteomes; UP000002258; Chromosome 7.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..721
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301806"
FT   REGION          27..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          555..614
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..54
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   721 AA;  82681 MW;  68B155ADCBA0C4DE CRC64;
     MSYNLPNPSL IGILLIISTH SGPQLIYKQP PGLTKEPDED EGEYDQEDIA ETESDEYGNY
     FEYDEDSNMY GTNLYKQWDA NHLNYYMGTK KDLISFLDEI ETKRKQASMK AVAKKRSQLS
     KIASNPSTIS TTGNSGNDSI FGIEPAYLCE MLAPPKKMCN SRFEIMIDDK IFLGLPVHKY
     DNGSWRLKGS SKRINRNKEE NTHQHEVDNS KSKLNLNMFH LVFIMNPPVI EYNYRIDEMF
     HYVISRLSLV LRYEQSKNDF ISNQVKMILN LKEQFKEKEE LESQLLNKSS LCKMIHDCYL
     SISQSKIANL SVNNKLRSFQ IPIKTEFHSL PESSVPFIPG SHLSSTVGLL GTTGLINVGE
     TTRYGEAMND ENEGISEAAD DIVYFALLLL DDAESIIRDI KTESSGTLAK FIRMINPTES
     LLKLSTRSNS LDTLQVKSFA FHLIYWRRAR VIQPLSTRSV YFVSPMAPIT TNLYTDIREF
     KKSFPTLPSL PQFLKLLSPQ SKKPSQFATV IPSKDHRDIY FEALSWLIRF GYVTQLQTFI
     WLKISRKIKI KVEEDLENES SSRKRSNITK KLLMGGTDNS SKDPAAESST DNRIMDQNDD
     KEENATKQLS NINAEDQEIE NIKERLKSTS LGPLVSLEDD DDTILLDPGR ATTLERRWIN
     KIIFDECKLS SELTNAFYKL LKYMDGKSPL ELLLLKENIS RTEIRKLLIA IEDHIISVRH
     W