NPR8_CAEEL
ID NPR8_CAEEL Reviewed; 490 AA.
AC Q18904;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Probable G-protein coupled receptor npr-8 {ECO:0000312|WormBase:C56G3.1a};
GN Name=npr-8 {ECO:0000312|WormBase:C56G3.1a};
GN ORFNames=C56G3.1 {ECO:0000312|WormBase:C56G3.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Not known. Putative receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; FO080413; CCD63510.1; -; Genomic_DNA.
DR PIR; T15875; T15875.
DR RefSeq; NP_741835.1; NM_171724.4.
DR AlphaFoldDB; Q18904; -.
DR SMR; Q18904; -.
DR STRING; 6239.C56G3.1b; -.
DR PaxDb; Q18904; -.
DR EnsemblMetazoa; C56G3.1a.1; C56G3.1a.1; WBGene00016984.
DR EnsemblMetazoa; C56G3.1a.2; C56G3.1a.2; WBGene00016984.
DR UCSC; C56G3.1a.2; c. elegans.
DR WormBase; C56G3.1a; CE04283; WBGene00016984; npr-8.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000168939; -.
DR HOGENOM; CLU_579001_0_0_1; -.
DR InParanoid; Q18904; -.
DR OrthoDB; 729498at2759; -.
DR PRO; PR:Q18904; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00016984; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; Q18904; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042923; F:neuropeptide binding; IBA:GO_Central.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000611; NPY_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01012; NRPEPTIDEYR.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..490
FT /note="Probable G-protein coupled receptor npr-8"
FT /evidence="ECO:0000305"
FT /id="PRO_0000070239"
FT TOPO_DOM 1..55
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..236
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..331
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 332..352
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 353..374
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 375..395
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 396..490
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 272..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..322
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 490 AA; 56243 MW; 531E1FFAE003CA62 CRC64;
MEVKDIDNYC DRGISPNASN YLTYPFDGLC LQKFFYQLQT SLRRFTPYEE IIYTTVYIII
SVAAVIGNGL VIMAVVRKKT MRTNRNVLIL NLALSNLILA ITNIPFLWLP SIDFEFPYSR
FFCKFANVLP GSNIYCSTLT ISVMAIDRYY SVKKLKIASN RKQCFHAVLV SLAIWIVSFI
LSLPLLLYYE TSMLYVMREI RVVDQSGQEV IRSYGWRQCR LVSAGRLPDI TQSIQLLMSI
LQVAFLYIVP LFVLSIFNVK LTRFLKTNAN KMSKTRAPPK RFDRSDSHHN SLKNNNNHTS
SLRSPSMPSI RSSITERNKT NQRTNRTTSL LIAMAGSYAA LWFPFTLITF LIDFELIINQ
DYVNLVERID QTCKMVSMLS ICVNPFLYGF LNTNFRHEFS DIYYRYIRCE TKSQPAGRFH
HDVSSIAHHR QDSVYNDEAT LLTTGRQSNG KDGSSSPIGF RSSVRVCSGQ TKMIGDRIVL
DDDIEKDSFV
