ID   NPRA_GEOSE              Reviewed;         406 AA.
AC   P43130;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Transcriptional activator NprA;
GN   Name=nprA;
OS   Geobacillus stearothermophilus (Bacillus stearothermophilus).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX   NCBI_TaxID=1422;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC   STRAIN=TELNE;
RX   PubMed=2203733; DOI=10.1128/jb.172.9.4861-4869.1990;
RA   Nishiya Y., Imanaka T.;
RT   "Cloning and nucleotide sequences of the Bacillus stearothermophilus
RT   neutral protease gene and its transcriptional activator gene.";
RL   J. Bacteriol. 172:4861-4869(1990).
CC   -!- FUNCTION: Activates the transcription of nprS by about five fold. May
CC       bind to the upstream region of nprS promoter.
CC       {ECO:0000269|PubMed:2203733}.
CC   -!- INDUCTION: Expressed in the late logarithmic growth phase.
CC       {ECO:0000269|PubMed:2203733}.
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DR   EMBL; M34237; AAA22624.1; -; Genomic_DNA.
DR   PIR; A36706; A36706.
DR   AlphaFoldDB; P43130; -.
DR   SMR; P43130; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50005; TPR; 4.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Repeat; TPR repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..406
FT                   /note="Transcriptional activator NprA"
FT                   /id="PRO_0000057947"
FT   REPEAT          125..158
FT                   /note="TPR 1"
FT   REPEAT          206..239
FT                   /note="TPR 2"
FT   REPEAT          246..279
FT                   /note="TPR 3"
FT   REPEAT          285..318
FT                   /note="TPR 4"
SQ   SEQUENCE   406 AA;  49154 MW;  A62ED350A1CFDD64 CRC64;
     MADGIISVSY LSKIENNQVV PSEEVLRLLC QRLGINNILK NRQDELTSKL LLWYKTITDK
     NRQEAARMYE EIKRTFDDVQ GAESIAYFLL FEMRYHLLLK DIHTVEALLI KLRELYDTFD
     DVMKYYYYKF LGLLYYCKEK YEDALEYYKK AEQRFRSQSF EKWEEADLHY LLALVYSRLW
     RILGCINYAQ HALAIYQSEY DLKRSAECHI LLGICYRRYG EVDQAIECYS LAHKIAQIIN
     DTELLGTIEH NLGYLMSMKH EHYEAIQHYK KSLLYKRNSS LQARFITLFS LIKEYYVSKN
     YKKALANVEE SLQLLKREKD GMTTYYEYYL HFTVYQYLLS EDISENEFET FMKDRVLPYF
     QRFKKYEDVA QYAEYLAIYY EKRHKYKLAS KFYKMSYQFL KNMINI