NPS3B_MOUSE
ID NPS3B_MOUSE Reviewed; 247 AA.
AC Q9CQE1; B1AWZ4; Q8VHX9;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein NipSnap homolog 3B;
DE Short=NipSnap3B;
DE AltName: Full=NipSnap-related protein;
DE AltName: Full=Protein NipSnap homolog 3A;
DE Short=NipSnap3A;
GN Name=Nipsnap3b; Synonyms=Nipsnap3a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Shaw D.J., Carrello A., Ward B.K., Temple S.E., Mark P.J., Minchin R.F.,
RA Ratajczak T.;
RT "Cloning and characterization of a novel NIPSNAP-related protein.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [7]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-45; LYS-48; LYS-57 AND LYS-166,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast, and Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Note=May be part of some
CC vesicular structure distinct from lysosomal vesicles. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NipSnap family. {ECO:0000305}.
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DR EMBL; AF353623; AAL56225.1; -; mRNA.
DR EMBL; AK004458; BAB23312.1; -; mRNA.
DR EMBL; AK008786; BAB25894.1; -; mRNA.
DR EMBL; AK012480; BAB28269.1; -; mRNA.
DR EMBL; AL772397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466565; EDL02287.1; -; Genomic_DNA.
DR EMBL; BC019505; AAH19505.1; -; mRNA.
DR CCDS; CCDS18186.1; -.
DR RefSeq; NP_079899.1; NM_025623.3.
DR AlphaFoldDB; Q9CQE1; -.
DR SMR; Q9CQE1; -.
DR BioGRID; 211542; 4.
DR IntAct; Q9CQE1; 1.
DR STRING; 10090.ENSMUSP00000015391; -.
DR iPTMnet; Q9CQE1; -.
DR PhosphoSitePlus; Q9CQE1; -.
DR SwissPalm; Q9CQE1; -.
DR EPD; Q9CQE1; -.
DR jPOST; Q9CQE1; -.
DR MaxQB; Q9CQE1; -.
DR PaxDb; Q9CQE1; -.
DR PeptideAtlas; Q9CQE1; -.
DR PRIDE; Q9CQE1; -.
DR ProteomicsDB; 293715; -.
DR Ensembl; ENSMUST00000015391; ENSMUSP00000015391; ENSMUSG00000015247.
DR GeneID; 66536; -.
DR KEGG; mmu:66536; -.
DR UCSC; uc008swt.1; mouse.
DR CTD; 55335; -.
DR MGI; MGI:1913786; Nipsnap3b.
DR VEuPathDB; HostDB:ENSMUSG00000015247; -.
DR eggNOG; KOG2883; Eukaryota.
DR GeneTree; ENSGT00950000183018; -.
DR HOGENOM; CLU_085919_0_1_1; -.
DR InParanoid; Q9CQE1; -.
DR OMA; AVHAHIN; -.
DR OrthoDB; 1141024at2759; -.
DR PhylomeDB; Q9CQE1; -.
DR TreeFam; TF314501; -.
DR BioGRID-ORCS; 66536; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q9CQE1; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9CQE1; protein.
DR Bgee; ENSMUSG00000015247; Expressed in epithelium of small intestine and 240 other tissues.
DR ExpressionAtlas; Q9CQE1; baseline and differential.
DR Genevisible; Q9CQE1; MM.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR012577; NIPSNAP.
DR Pfam; PF07978; NIPSNAP; 2.
DR SUPFAM; SSF54909; SSF54909; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..247
FT /note="Protein NipSnap homolog 3B"
FT /id="PRO_0000221155"
FT MOD_RES 45
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 48
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 57
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT MOD_RES 166
FT /note="N6-succinyllysine"
FT /evidence="ECO:0007744|PubMed:23806337"
FT CONFLICT 5
FT /note="R -> L (in Ref. 1; AAL56225)"
FT /evidence="ECO:0000305"
FT CONFLICT 33
FT /note="N -> D (in Ref. 1; AAL56225)"
FT /evidence="ECO:0000305"
FT CONFLICT 36
FT /note="F -> L (in Ref. 1; AAL56225)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 247 AA; 28308 MW; 99791350D557956C CRC64;
MLALRSGLRT ALAPRVLTPQ VCSPFATGPR QSNGTFYEFR TYFLKPSKTN EFLENFKNSV
HLRTAHSEMI GYWTVEFGGR TNRVFHIWKY DNFAHRTAVR KALAKDKEWQ ERFLIPNLAF
IDKQEVEITY LVPWCKIGTP PKEGVYELAT FQMKPGGPAL WGNAFKRAVN AHVELGYSTL
VGVFHTEYGA LNRVHVLWWN ESADSRAAGR HWSHEDPRVV AAVRESVSYL ESQQNTFLIP
TSFSPLK
