NPSR1_HUMAN
ID NPSR1_HUMAN Reviewed; 371 AA.
AC Q6W5P4; A2RTZ4; Q2XP58; Q56H76; Q56H77; Q56H78; Q6JSL4; Q6JSL5; Q6JSL6;
AC Q6JSL7; Q6JSL8; Q6W5P3; Q6ZMB8;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Neuropeptide S receptor;
DE AltName: Full=G-protein coupled receptor 154;
DE AltName: Full=G-protein coupled receptor PGR14;
DE AltName: Full=G-protein coupled receptor for asthma susceptibility;
GN Name=NPSR1; Synonyms=GPR154, GPRA, PGR14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4), VARIANT ILE-107, INVOLVEMENT
RP IN ASRT2, AND TISSUE SPECIFICITY.
RX PubMed=15073379; DOI=10.1126/science.1090010;
RA Laitinen T., Polvi A., Rydman P., Vendelin J., Pulkkinen V.,
RA Salmikangas P., Maekelae S., Rehn M., Pirskanen A., Rautanen A.,
RA Zucchelli M., Gullsten H., Leino M., Alenius H., Petaeys T., Haahtela T.,
RA Laitinen A., Laprise C., Hudson T.J., Laitinen L.A., Kere J.;
RT "Characterization of a common susceptibility locus for asthma-related
RT traits.";
RL Science 304:300-304(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 5; 6; 7 AND 9), FUNCTION,
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15947423; DOI=10.1165/rcmb.2004-0405oc;
RA Vendelin J., Pulkkinen V., Rehn M., Pirskanen A., Raisanen-Sokolowski A.,
RA Laitinen A., Laitinen L.A., Kere J., Laitinen T.;
RT "Characterization of GPRA, a novel G protein-coupled receptor related to
RT asthma.";
RL Am. J. Respir. Cell Mol. Biol. 33:262-270(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), AND VARIANT ILE-107.
RA Uebele V.N.;
RT "Human neuropeptide S receptor isoforms A and G: nucleotide and deduced
RT amino acid sequence.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 8), AND VARIANT ILE-107.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS ILE-107; GLN-122; GLY-143;
RP PHE-197; ILE-212; ARG-241; THR-315 AND ARG-344.
RG SeattleSNPs variation discovery resource;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP FUNCTION.
RX PubMed=15312648; DOI=10.1016/j.neuron.2004.08.005;
RA Xu Y.-L., Reinscheid R.K., Huitron-Resendiz S., Clark S.D., Wang Z.,
RA Lin S.H., Brucher F.A., Zeng J., Ly N.K., Henriksen S.J., de Lecea L.,
RA Civelli O.;
RT "Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like
RT effects.";
RL Neuron 43:487-497(2004).
RN [9]
RP INVOLVEMENT IN ASRT2.
RX PubMed=15710598; DOI=10.1164/rccm.200410-1317oc;
RA Melen E., Bruce S., Doekes G., Kabesch M., Laitinen T., Lauener R.,
RA Lindgren C.M., Riedler J., Scheynius A., van Hage-Hamsten M., Kere J.,
RA Pershagen G., Wickman M., Nyberg F.;
RT "Haplotypes of G protein-coupled receptor 154 are associated with childhood
RT allergy and asthma.";
RL Am. J. Respir. Crit. Care Med. 171:1089-1095(2005).
RN [10]
RP INVOLVEMENT IN ASRT2.
RX PubMed=15764725; DOI=10.1164/rccm.200410-1312oc;
RA Kormann M.S., Carr D., Klopp N., Illig T., Leupold W., Fritzsch C.,
RA Weiland S.K., von Mutius E., Kabesch M.;
RT "G-protein-coupled receptor polymorphisms are associated with asthma in a
RT large German population.";
RL Am. J. Respir. Crit. Care Med. 171:1358-1362(2005).
RN [11]
RP CHARACTERIZATION OF VARIANT ILE-107, SUBCELLULAR LOCATION, AND FUNCTION.
RX PubMed=16790440; DOI=10.1074/jbc.m603691200;
RA Bernier V., Stocco R., Bogusky M.J., Joyce J.G., Parachoniak C.,
RA Grenier K., Arget M., Mathieu M.C., O'Neill G.P., Slipetz D.,
RA Crackower M.A., Tan C.M., Therien A.G.;
RT "Structure-function relationships in the neuropeptide S receptor: molecular
RT consequences of the asthma-associated mutation N107I.";
RL J. Biol. Chem. 281:24704-24712(2006).
CC -!- FUNCTION: G-protein coupled receptor for neuropeptide S (NPS)
CC (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores
CC (PubMed:16790440). Inhibits cell growth in response to NPS binding
CC (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-
CC mediated diseases. {ECO:0000269|PubMed:15312648,
CC ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16790440}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane
CC {ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16790440}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane
CC {ECO:0000269|PubMed:15947423}; Multi-pass membrane protein
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane
CC {ECO:0000269|PubMed:15947423}; Multi-pass membrane protein
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm
CC {ECO:0000269|PubMed:15947423}.
CC -!- SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm
CC {ECO:0000269|PubMed:15947423}.
CC -!- SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm
CC {ECO:0000269|PubMed:15947423}.
CC -!- SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm
CC {ECO:0000269|PubMed:15947423}.
CC -!- SUBCELLULAR LOCATION: [Isoform 9]: Cytoplasm
CC {ECO:0000269|PubMed:15947423}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=9;
CC Name=1; Synonyms=Isoform A;
CC IsoId=Q6W5P4-1; Sequence=Displayed;
CC Name=2; Synonyms=Isoform F;
CC IsoId=Q6W5P4-2; Sequence=VSP_016079;
CC Name=3; Synonyms=Isoform G;
CC IsoId=Q6W5P4-3; Sequence=VSP_016088;
CC Name=4; Synonyms=Isoform B long form;
CC IsoId=Q6W5P4-4; Sequence=VSP_016089;
CC Name=5; Synonyms=Isoform B short form;
CC IsoId=Q6W5P4-5; Sequence=VSP_016078, VSP_016089;
CC Name=6; Synonyms=Isoform D;
CC IsoId=Q6W5P4-6; Sequence=VSP_016080, VSP_016087;
CC Name=7; Synonyms=Isoform E;
CC IsoId=Q6W5P4-7; Sequence=VSP_016083, VSP_016085;
CC Name=8;
CC IsoId=Q6W5P4-8; Sequence=VSP_016084, VSP_016086;
CC Name=9; Synonyms=Isoform C;
CC IsoId=Q6W5P4-9; Sequence=VSP_016081, VSP_016082;
CC -!- TISSUE SPECIFICITY: Isoform 4 is ubiquitous; it is detected in
CC glandular epithelia of bronchus, stomach, small intestine, colon,
CC uterus, esophagus, spleen, kidney, pancreas, prostate and breast.
CC Isoform 1 is detected in uterus, colon and prostate, and in the smooth
CC muscle cell layer in bronchial and arterial walls (at protein level)
CC (PubMed:15947423). Isoform 1 is predominantly expressed in smooth
CC muscle. Isoform 4 is predominantly expressed in epithelial cells. In
CC bronchial biopsies, it is expressed in smooth muscle cells of asthma
CC patients, but not in control patients; whereas in epithelial cells, its
CC expression is consistently stronger in asthma patients.
CC {ECO:0000269|PubMed:15073379, ECO:0000269|PubMed:15947423}.
CC -!- DISEASE: Asthma-related traits 2 (ASRT2) [MIM:608584]: Asthma-related
CC traits include clinical symptoms of asthma, such as coughing, wheezing,
CC dyspnea, bronchial hyperresponsiveness as assessed by methacholine
CC challenge test, serum IgE levels, atopy and atopic dermatitis.
CC {ECO:0000269|PubMed:15073379, ECO:0000269|PubMed:15710598,
CC ECO:0000269|PubMed:15764725}. Note=Disease susceptibility is associated
CC with variants affecting the gene represented in this entry.
CC -!- MISCELLANEOUS: Only isoforms with 7 transmembrane topology (isoform 1,
CC isoform 3 and isoform 4) are transported into the plasma membrane in
CC transfected cells, while the truncated ones retain intracellular
CC compartments. {ECO:0000269|PubMed:15947423}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/gpr154/";
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DR EMBL; AY310326; AAQ76966.1; -; mRNA.
DR EMBL; AY310327; AAQ76967.1; -; mRNA.
DR EMBL; AY310328; AAQ76968.1; -; mRNA.
DR EMBL; AY310329; AAQ76969.1; -; mRNA.
DR EMBL; AY310330; AAQ76970.1; -; mRNA.
DR EMBL; AY310331; AAQ76971.1; -; mRNA.
DR EMBL; AY310332; AAQ76972.1; -; mRNA.
DR EMBL; AY956446; AAX63744.1; -; mRNA.
DR EMBL; AY956447; AAX63745.1; -; mRNA.
DR EMBL; AY956448; AAX63746.1; -; mRNA.
DR EMBL; AK172847; BAD18811.1; -; mRNA.
DR EMBL; DQ272236; ABB72550.1; -; Genomic_DNA.
DR EMBL; CH471073; EAW94036.1; -; Genomic_DNA.
DR EMBL; BC132693; AAI32694.1; -; mRNA.
DR EMBL; BC132695; AAI32696.1; -; mRNA.
DR CCDS; CCDS5443.1; -. [Q6W5P4-4]
DR CCDS; CCDS5444.1; -. [Q6W5P4-1]
DR CCDS; CCDS75579.1; -. [Q6W5P4-3]
DR CCDS; CCDS75580.1; -. [Q6W5P4-5]
DR CCDS; CCDS75581.1; -. [Q6W5P4-2]
DR RefSeq; NP_001287862.1; NM_001300933.1. [Q6W5P4-5]
DR RefSeq; NP_001287863.1; NM_001300934.1. [Q6W5P4-2]
DR RefSeq; NP_001287864.1; NM_001300935.1. [Q6W5P4-3]
DR RefSeq; NP_997055.1; NM_207172.1. [Q6W5P4-1]
DR RefSeq; NP_997056.1; NM_207173.1. [Q6W5P4-4]
DR AlphaFoldDB; Q6W5P4; -.
DR SMR; Q6W5P4; -.
DR BioGRID; 132263; 38.
DR IntAct; Q6W5P4; 16.
DR MINT; Q6W5P4; -.
DR STRING; 9606.ENSP00000370950; -.
DR BindingDB; Q6W5P4; -.
DR ChEMBL; CHEMBL5162; -.
DR DrugBank; DB01159; Halothane.
DR GuidetoPHARMACOLOGY; 302; -.
DR TCDB; 9.A.14.10.5; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; Q6W5P4; 1 site.
DR iPTMnet; Q6W5P4; -.
DR PhosphoSitePlus; Q6W5P4; -.
DR BioMuta; NPSR1; -.
DR DMDM; 74758626; -.
DR EPD; Q6W5P4; -.
DR PaxDb; Q6W5P4; -.
DR PeptideAtlas; Q6W5P4; -.
DR PRIDE; Q6W5P4; -.
DR ProteomicsDB; 67746; -. [Q6W5P4-2]
DR Antibodypedia; 1941; 198 antibodies from 27 providers.
DR DNASU; 387129; -.
DR Ensembl; ENST00000359791.5; ENSP00000352839.1; ENSG00000187258.14. [Q6W5P4-4]
DR Ensembl; ENST00000360581.6; ENSP00000353788.1; ENSG00000187258.14. [Q6W5P4-1]
DR Ensembl; ENST00000381539.3; ENSP00000370950.3; ENSG00000187258.14. [Q6W5P4-3]
DR Ensembl; ENST00000381542.5; ENSP00000370953.1; ENSG00000187258.14. [Q6W5P4-2]
DR Ensembl; ENST00000381544.6; ENSP00000370955.2; ENSG00000187258.14. [Q6W5P4-6]
DR Ensembl; ENST00000381553.7; ENSP00000370965.3; ENSG00000187258.14. [Q6W5P4-8]
DR Ensembl; ENST00000396095.6; ENSP00000379402.2; ENSG00000187258.14. [Q6W5P4-7]
DR Ensembl; ENST00000465305.5; ENSP00000434955.1; ENSG00000187258.14. [Q6W5P4-9]
DR Ensembl; ENST00000531252.5; ENSP00000433258.1; ENSG00000187258.14. [Q6W5P4-5]
DR GeneID; 387129; -.
DR KEGG; hsa:387129; -.
DR MANE-Select; ENST00000360581.6; ENSP00000353788.1; NM_207172.2; NP_997055.1.
DR UCSC; uc003teg.1; human. [Q6W5P4-1]
DR CTD; 387129; -.
DR DisGeNET; 387129; -.
DR GeneCards; NPSR1; -.
DR HGNC; HGNC:23631; NPSR1.
DR HPA; ENSG00000187258; Tissue enhanced (brain).
DR MalaCards; NPSR1; -.
DR MIM; 608584; phenotype.
DR MIM; 608595; gene.
DR neXtProt; NX_Q6W5P4; -.
DR OpenTargets; ENSG00000187258; -.
DR PharmGKB; PA134951416; -.
DR VEuPathDB; HostDB:ENSG00000187258; -.
DR eggNOG; KOG3184; Eukaryota.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000155094; -.
DR HOGENOM; CLU_2385563_0_0_1; -.
DR InParanoid; Q6W5P4; -.
DR OMA; WIPYMTV; -.
DR OrthoDB; 1034048at2759; -.
DR PhylomeDB; Q6W5P4; -.
DR TreeFam; TF106499; -.
DR PathwayCommons; Q6W5P4; -.
DR Reactome; R-HSA-375276; Peptide ligand-binding receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR Reactome; R-HSA-9660821; ADORA2B mediated anti-inflammatory cytokines production.
DR SignaLink; Q6W5P4; -.
DR BioGRID-ORCS; 387129; 12 hits in 1073 CRISPR screens.
DR ChiTaRS; NPSR1; human.
DR GeneWiki; Neuropeptide_S_receptor; -.
DR GenomeRNAi; 387129; -.
DR Pharos; Q6W5P4; Tchem.
DR PRO; PR:Q6W5P4; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q6W5P4; protein.
DR Bgee; ENSG00000187258; Expressed in ganglionic eminence and 21 other tissues.
DR ExpressionAtlas; Q6W5P4; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0008188; F:neuropeptide receptor activity; IDA:UniProtKB.
DR GO; GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
DR GO; GO:0042755; P:eating behavior; IEA:Ensembl.
DR GO; GO:2000293; P:negative regulation of defecation; IEA:Ensembl.
DR GO; GO:1903999; P:negative regulation of eating behavior; IEA:Ensembl.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:UniProtKB.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IDA:UniProtKB.
DR GO; GO:0060013; P:righting reflex; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR027294; NPS_rcpt.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR PANTHER; PTHR24244:SF2; PTHR24244:SF2; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Asthma; Cell membrane; Cytoplasm; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..371
FT /note="Neuropeptide S receptor"
FT /id="PRO_0000069639"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..312
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..371
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 121..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VAR_SEQ 93..103
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15947423"
FT /id="VSP_016078"
FT VAR_SEQ 94..159
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15947423"
FT /id="VSP_016079"
FT VAR_SEQ 94..158
FT /note="DSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSID
FT RYHAIVYPMKFLQ -> GCAALRLYLRPGVPQHRQIPCHRLPHEVPSRRKASQGPHCDR
FT LEPVFSVLHSHPDHIWEEDTVQR (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15947423"
FT /id="VSP_016080"
FT VAR_SEQ 94
FT /note="D -> V (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:15947423"
FT /id="VSP_016081"
FT VAR_SEQ 95..371
FT /note="Missing (in isoform 9)"
FT /evidence="ECO:0000303|PubMed:15947423"
FT /id="VSP_016082"
FT VAR_SEQ 129..136
FT /note="VVLLYAST -> KSKPGSSL (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:15947423"
FT /id="VSP_016083"
FT VAR_SEQ 130..143
FT /note="VLLYASTYVLVSLS -> MVMKLFHIQKMNME (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016084"
FT VAR_SEQ 137..371
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:15947423"
FT /id="VSP_016085"
FT VAR_SEQ 144..371
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016086"
FT VAR_SEQ 159..371
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15947423"
FT /id="VSP_016087"
FT VAR_SEQ 343..371
FT /note="EQRSQDSRMTFRERTERHEMQILSKPEFI -> ANSSVYLLACDVSVLWALV
FT LTSEKESCESWRRKGAKITGFQNDVPGEN (in isoform 3)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_016088"
FT VAR_SEQ 343..371
FT /note="EQRSQDSRMTFRERTERHEMQILSKPEFI -> VIRLRQLQEAALMLCPQRE
FT NWKGTWPGVPSWALPR (in isoform 4 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:15073379,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:15947423"
FT /id="VSP_016089"
FT VARIANT 107
FT /note="N -> I (increases cell surface expression and NPS-
FT dependent calcium mobilization; does not affect affinity
FT for NPS.; dbSNP:rs324981)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15073379, ECO:0000269|PubMed:16790440,
FT ECO:0000269|Ref.3, ECO:0000269|Ref.5"
FT /id="VAR_023757"
FT VARIANT 122
FT /note="R -> Q (in dbSNP:rs35436513)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_025103"
FT VARIANT 143
FT /note="S -> G (in dbSNP:rs325465)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_025104"
FT VARIANT 197
FT /note="C -> F (in dbSNP:rs34705969)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_025105"
FT VARIANT 212
FT /note="T -> I (in dbSNP:rs35537374)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_025106"
FT VARIANT 241
FT /note="S -> R (in dbSNP:rs727162)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_023758"
FT VARIANT 315
FT /note="I -> T (in dbSNP:rs10270766)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_025107"
FT VARIANT 344
FT /note="Q -> R (in dbSNP:rs6972158)"
FT /evidence="ECO:0000269|Ref.5"
FT /id="VAR_023759"
SQ SEQUENCE 371 AA; 42687 MW; EA084B381562353D CRC64;
MPANFTEGSF DSSGTGQTLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF
VFTIVGNSVV LFSTWRRKKK SRMTFFVTQL AITDSFTGLV NILTDINWRF TGDFTAPDLV
CRVVRYLQVV LLYASTYVLV SLSIDRYHAI VYPMKFLQGE KQARVLIVIA WSLSFLFSIP
TLIIFGKRTL SNGEVQCWAL WPDDSYWTPY MTIVAFLVYF IPLTIISIMY GIVIRTIWIK
SKTYETVISN CSDGKLCSSY NRGLISKAKI KAIKYSIIII LAFICCWSPY FLFDILDNFN
LLPDTQERFY ASVIIQNLPA LNSAINPLIY CVFSSSISFP CREQRSQDSR MTFRERTERH
EMQILSKPEF I
