NPSR1_MACMU
ID NPSR1_MACMU Reviewed; 371 AA.
AC Q56H79; Q58HF3;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Neuropeptide S receptor;
DE AltName: Full=G-protein coupled receptor 154;
GN Name=NPSR1; Synonyms=GPR154;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Uebele V.N.;
RT "Rhesus neuropeptide S receptor nucleotide and deduced amino acid
RT sequence.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: G-protein coupled receptor for neuropeptide S (NPS). Promotes
CC mobilization of intracellular Ca(2+) stores. Inhibits cell growth in
CC response to NPS binding. Involved in pathogenesis of asthma and other
CC IgE-mediated diseases. {ECO:0000250|UniProtKB:Q6W5P4}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6W5P4};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6W5P4}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; AY950595; AAX47273.1; -; mRNA.
DR EMBL; AY956445; AAX63743.1; -; mRNA.
DR RefSeq; NP_001028114.1; NM_001032942.1.
DR AlphaFoldDB; Q56H79; -.
DR SMR; Q56H79; -.
DR STRING; 9544.ENSMMUP00000018684; -.
DR GeneID; 574355; -.
DR KEGG; mcc:574355; -.
DR CTD; 387129; -.
DR eggNOG; KOG3184; Eukaryota.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; Q56H79; -.
DR OrthoDB; 1034048at2759; -.
DR Proteomes; UP000006718; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0008188; F:neuropeptide receptor activity; ISS:UniProtKB.
DR GO; GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR GO; GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; ISS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR027294; NPS_rcpt.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR PANTHER; PTHR24244:SF2; PTHR24244:SF2; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Neuropeptide; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..371
FT /note="Neuropeptide S receptor"
FT /id="PRO_0000069640"
FT TOPO_DOM 1..52
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 74..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 145..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..312
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 313..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..371
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 13
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 121..197
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 95
FT /note="S -> Y (in Ref. 1; AAX47273)"
FT /evidence="ECO:0000305"
FT CONFLICT 129
FT /note="V -> A (in Ref. 1; AAX47273)"
FT /evidence="ECO:0000305"
FT CONFLICT 350
FT /note="I -> R (in Ref. 1; AAX47273)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 371 AA; 42631 MW; 0DF59F847F3414B6 CRC64;
MPANFTEGSF DSNGTGQMLD SSPVACTETV TFTEVVEGKE WGSFYYSFKT EQLITLWVLF
VFTIVGNSVV LFSTWRRKRK SRMTFFVTQL AITDSFTGLV NILTDIIWRF TGDFMAPDLV
CRVVRYLQVV LLYASTYVLV SLSIDRYHAI VYPMKFLQGE KQAKVLIVIA WSLSFLFSIP
TLIIFGKRTL SNGEVQCWAL WPDDSYWTPY MTIVAFLVYF IPLTIISVMY GIVIRTIWIK
SKTYETVISN CSDGKLCSSY NRGLISKAKI KAIKYSIVII LAFICCWSPY FLFDILDNFN
LLPDTQERFY ASVIIQNLPA LNSAINPLIY CVFSSSISFP CGERRSQDSI MTFRERTERH
EMQILSKPEF I
