ID   NPS_BOVIN               Reviewed;          89 AA.
AC   P0C0P5;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Neuropeptide S;
DE   Flags: Precursor;
GN   Name=NPS;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Smith T.P.L., Roberts A.J., Echternkamp S.E., Chitko-McKown C.G.,
RA   Wray J.E., Keele J.W.;
RT   "A second set of bovine ESTs from pooled-tissue normalized libraries.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates arousal and anxiety. May play an important
CC       anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity
CC       to increase intracellular calcium concentrations (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   EMBL; DN276816; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0C0P5; -.
DR   InParanoid; P0C0P5; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR028138; Neuropeptide_S.
DR   PANTHER; PTHR36679; PTHR36679; 1.
DR   Pfam; PF14993; Neuropeptide_S; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Neuropeptide; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..67
FT                   /id="PRO_0000042886"
FT   PEPTIDE         70..89
FT                   /note="Neuropeptide S"
FT                   /id="PRO_0000042887"
SQ   SEQUENCE   89 AA;  10261 MW;  E05B1C5250924D09 CRC64;
     MIGSLKFNFI LFLLISTMHM FWCHPISSSK VPGKSDYFVI LLNSCPTRMD RRVGLDFLKP
     ILEKTLMKRS FRNGVGTGMK KTSFRRAKS