NPS_MOUSE
ID NPS_MOUSE Reviewed; 89 AA.
AC P0C0P8;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Neuropeptide S;
DE Flags: Precursor;
GN Name=Nps;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Sato S., Shintani Y., Miyajima N., Yoshimura K.;
RT "Novel G protein-coupled receptor protein and its DNA.";
RL Patent number WO0231145, 18-APR-2002.
RN [2]
RP FUNCTION.
RX PubMed=16279934; DOI=10.1111/j.1742-4658.2005.04982.x;
RA Reinscheid R.K., Xu Y.L.;
RT "Neuropeptide S as a novel arousal promoting peptide transmitter.";
RL FEBS J. 272:5689-5693(2005).
CC -!- FUNCTION: May play an important anorexigenic role. Modulates arousal
CC and anxiety as well as increases locomotor activity. Binds to its
CC receptor NPSR1 with nanomolar affinity to increase intracellular
CC calcium concentrations. {ECO:0000269|PubMed:16279934}.
CC -!- SUBCELLULAR LOCATION: Secreted.
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DR EMBL; BD168690; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR CCDS; CCDS52420.1; -.
DR RefSeq; NP_001157083.1; NM_001163611.1.
DR AlphaFoldDB; P0C0P8; -.
DR STRING; 10090.ENSMUSP00000095597; -.
DR PaxDb; P0C0P8; -.
DR PRIDE; P0C0P8; -.
DR Antibodypedia; 57702; 136 antibodies from 19 providers.
DR Ensembl; ENSMUST00000097983; ENSMUSP00000095597; ENSMUSG00000073804.
DR GeneID; 100043254; -.
DR KEGG; mmu:100043254; -.
DR UCSC; uc012fvj.1; mouse.
DR CTD; 594857; -.
DR MGI; MGI:3642232; Nps.
DR VEuPathDB; HostDB:ENSMUSG00000073804; -.
DR eggNOG; ENOG502SSTA; Eukaryota.
DR GeneTree; ENSGT00400000024769; -.
DR HOGENOM; CLU_2432613_0_0_1; -.
DR InParanoid; P0C0P8; -.
DR OMA; KSDYCLV; -.
DR OrthoDB; 1613904at2759; -.
DR PhylomeDB; P0C0P8; -.
DR Reactome; R-MMU-375276; Peptide ligand-binding receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR BioGRID-ORCS; 100043254; 3 hits in 71 CRISPR screens.
DR PRO; PR:P0C0P8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P0C0P8; protein.
DR Bgee; ENSMUSG00000073804; Expressed in spermatocyte and 6 other tissues.
DR ExpressionAtlas; P0C0P8; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0045760; P:positive regulation of action potential; IDA:MGI.
DR GO; GO:0010841; P:positive regulation of circadian sleep/wake cycle, wakefulness; ISO:MGI.
DR GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IDA:MGI.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IDA:MGI.
DR GO; GO:0035249; P:synaptic transmission, glutamatergic; IDA:MGI.
DR GO; GO:0008542; P:visual learning; IDA:MGI.
DR InterPro; IPR028138; Neuropeptide_S.
DR PANTHER; PTHR36679; PTHR36679; 1.
DR Pfam; PF14993; Neuropeptide_S; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues; Neuropeptide; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..69
FT /id="PRO_0000042941"
FT PEPTIDE 70..89
FT /note="Neuropeptide S"
FT /id="PRO_0000042942"
SQ SEQUENCE 89 AA; 9861 MW; A2C8208D20107D59 CRC64;
MIGSLKLSFV LALSLSVMHV LWCYPVLSSK VPGKPDYFLI LLSSCPARLE GSDRLAFLKP
ILEKTSMKRS FRNGVGSGAK KTSFRRAKQ
