ID   NPS_RAT                 Reviewed;          89 AA.
AC   P0C0P7;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Neuropeptide S;
DE   Flags: Precursor;
GN   Name=Nps;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Sato S., Shintani Y., Miyajima N., Yoshimura K.;
RT   "Novel G protein-coupled receptor protein and its DNA.";
RL   Patent number WO0231145, 18-APR-2002.
RN   [2]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=15312648; DOI=10.1016/j.neuron.2004.08.005;
RA   Xu Y.-L., Reinscheid R.K., Huitron-Resendiz S., Clark S.D., Wang Z.,
RA   Lin S.H., Brucher F.A., Zeng J., Ly N.K., Henriksen S.J., de Lecea L.,
RA   Civelli O.;
RT   "Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like
RT   effects.";
RL   Neuron 43:487-497(2004).
RN   [3]
RP   FUNCTION.
RX   PubMed=15919054; DOI=10.1016/j.bbrc.2005.05.029;
RA   Beck B., Fernette B., Stricker-Krongrad A.;
RT   "Peptide S is a novel potent inhibitor of voluntary and fast-induced food
RT   intake in rats.";
RL   Biochem. Biophys. Res. Commun. 332:859-865(2005).
CC   -!- FUNCTION: May play an important anorexigenic role. Modulates arousal
CC       and anxiety as well as increases locomotor activity. Binds to its
CC       receptor NPSR1 with nanomolar affinity to increase intracellular
CC       calcium concentrations. {ECO:0000269|PubMed:15312648,
CC       ECO:0000269|PubMed:15919054}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in mammary, salivary and thyroid gland.
CC       Expressed in the brain, in a cluster of cells located between the locus
CC       coeruleus (LC) and Barrington's nucleus, as well as in few cells of the
CC       dorsomedial hypothalamic nucleus and the amygdala.
CC       {ECO:0000269|PubMed:15312648}.
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DR   EMBL; BD168712; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   RefSeq; NP_001258042.1; NM_001271113.1.
DR   AlphaFoldDB; P0C0P7; -.
DR   SMR; P0C0P7; -.
DR   STRING; 10116.ENSRNOP00000051780; -.
DR   PaxDb; P0C0P7; -.
DR   Ensembl; ENSRNOT00000054896; ENSRNOP00000051780; ENSRNOG00000036653.
DR   GeneID; 100360071; -.
DR   KEGG; rno:100360071; -.
DR   UCSC; RGD:2324597; rat.
DR   CTD; 594857; -.
DR   RGD; 2324597; Nps.
DR   eggNOG; ENOG502SSTA; Eukaryota.
DR   GeneTree; ENSGT00400000024769; -.
DR   HOGENOM; CLU_2432613_0_0_1; -.
DR   InParanoid; P0C0P7; -.
DR   OMA; KSDYCLV; -.
DR   OrthoDB; 1613904at2759; -.
DR   PhylomeDB; P0C0P7; -.
DR   Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR   Reactome; R-RNO-416476; G alpha (q) signalling events.
DR   PRO; PR:P0C0P7; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000036653; Expressed in brain.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0045760; P:positive regulation of action potential; ISO:RGD.
DR   GO; GO:0010841; P:positive regulation of circadian sleep/wake cycle, wakefulness; IDA:RGD.
DR   GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; ISO:RGD.
DR   GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; ISO:RGD.
DR   GO; GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
DR   GO; GO:0008542; P:visual learning; ISO:RGD.
DR   InterPro; IPR028138; Neuropeptide_S.
DR   PANTHER; PTHR36679; PTHR36679; 1.
DR   Pfam; PF14993; Neuropeptide_S; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Neuropeptide; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..69
FT                   /id="PRO_0000042943"
FT   PEPTIDE         70..89
FT                   /note="Neuropeptide S"
FT                   /id="PRO_0000042944"
SQ   SEQUENCE   89 AA;  9763 MW;  2FB73057DFB35AB9 CRC64;
     MIGSLKLNLI LALSLSVVHV IWSYPVLSSK VPGKPDYFLI LLSTCPARLE GSDGLAFLKP
     ILEKTSMKRS FRNGVGSGVK KTSFRRAKQ