NPT1_RAT
ID NPT1_RAT Reviewed; 465 AA.
AC Q62795;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Sodium-dependent phosphate transport protein 1;
DE AltName: Full=Na(+)/PI cotransporter 1;
DE AltName: Full=Renal Na(+)-dependent phosphate cotransporter 1;
DE AltName: Full=Renal sodium-dependent phosphate transport protein 1;
DE Short=Renal sodium-phosphate transport protein 1;
DE AltName: Full=Sodium/phosphate cotransporter 1;
DE AltName: Full=Solute carrier family 17 member 1;
GN Name=Slc17a1; Synonyms=Npt1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=8867793;
RA Li H., Xie Z.;
RT "Molecular cloning of two rat Na+/Pi cotransporters: evidence for
RT differential tissue expression of transcripts.";
RL Cell. Mol. Biol. Res. 41:451-460(1995).
CC -!- FUNCTION: Important for the resorption of phosphate by the kidney. May
CC be involved in actively transporting phosphate into cells via Na(+)
CC cotransport in the renal brush border membrane. Plays a role in urate
CC transport in the kidney. {ECO:0000250|UniProtKB:Q14916}.
CC -!- SUBUNIT: Interacts with PDZK1. {ECO:0000250|UniProtKB:Q61983}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000250|UniProtKB:Q14916}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC cotransporter family. {ECO:0000305}.
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DR EMBL; U28504; AAC52487.1; -; mRNA.
DR AlphaFoldDB; Q62795; -.
DR SMR; Q62795; -.
DR STRING; 10116.ENSRNOP00000061056; -.
DR BindingDB; Q62795; -.
DR ChEMBL; CHEMBL3398; -.
DR GlyGen; Q62795; 3 sites.
DR PaxDb; Q62795; -.
DR RGD; 620099; Slc17a1.
DR eggNOG; KOG2532; Eukaryota.
DR InParanoid; Q62795; -.
DR PhylomeDB; Q62795; -.
DR Reactome; R-RNO-428643; Organic anion transporters.
DR PRO; PR:Q62795; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015136; F:sialic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005436; F:sodium:phosphate symporter activity; TAS:RGD.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006820; P:anion transport; IBA:GO_Central.
DR GO; GO:0015739; P:sialic acid transport; IBA:GO_Central.
DR GO; GO:0046415; P:urate metabolic process; ISO:RGD.
DR GO; GO:0015747; P:urate transport; ISS:UniProtKB.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004745; Pi_cotranspt.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00894; 2A0114euk; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Ion transport; Membrane; Reference proteome;
KW Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..465
FT /note="Sodium-dependent phosphate transport protein 1"
FT /id="PRO_0000220939"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 431..451
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 465 AA; 51350 MW; 28BBBF8DC5C0AC52 CRC64;
MENRCLPKKV PGFCSFRYGL AILLHFCNIV IMAQRVCLNL TMVAMVNKTE PPHLSNKSVA
EMLDNVKNPV HSWSLDIQGL VLSSVFLGMV VIQVPVGYLS GAYPMEKIIG SSLFLSSVLS
LLIPPAAQVG AALVIVCRVL QGIAQGAVST GQHGIWVKWA PPLERGRLTS MTLSGFVMGP
FIALLVSGFI CDLLGWPMVF YIFGIVGCVL SLFWFILLFD DPNNHPYMSS SEKDYITSSL
MQQVHSGRQS LPIKAMLKSL PLWAIILNSF AFIWSNNLLV TYTPTFISTT LHVNVRENGL
LSSLPYLLAY ICGIVAGQMS DFLLSRKIFS VVAVRKLFTT LGIFCPVIFV VCLLYLSYNF
YSTVIFLTLA NSTLSFSFCG QLINALDIAP RYYGFLKAVT ALIGIFGGLI SSTLAGLILN
QDPEYAWHKN FFLMAGINVT CLAFYLLFAK GDIQDWAKET KTTRL
