NPT2B_PONAB
ID NPT2B_PONAB Reviewed; 689 AA.
AC Q5REV9;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Sodium-dependent phosphate transport protein 2B;
DE Short=Sodium-phosphate transport protein 2B;
DE AltName: Full=Na(+)-dependent phosphate cotransporter 2B;
DE AltName: Full=Sodium/phosphate cotransporter 2B;
DE Short=Na(+)/Pi cotransporter 2B;
DE Short=NaPi-2b;
DE AltName: Full=Solute carrier family 34 member 2;
GN Name=SLC34A2;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in actively transporting phosphate into cells via
CC Na(+) cotransport. {ECO:0000250|UniProtKB:O95436}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in);
CC Xref=Rhea:RHEA:71255, ChEBI:CHEBI:29101, ChEBI:CHEBI:43474;
CC Evidence={ECO:0000250|UniProtKB:O95436};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:71256;
CC Evidence={ECO:0000250|UniProtKB:O95436};
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000250|UniProtKB:Q9DBP0}; Multi-pass membrane protein
CC {ECO:0000255}. Note=Localized at the brush border membranes of
CC enterocytes. {ECO:0000250|UniProtKB:Q9DBP0}.
CC -!- SIMILARITY: Belongs to the SLC34A transporter family. {ECO:0000305}.
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DR EMBL; CR857407; CAH89698.1; -; mRNA.
DR RefSeq; NP_001124770.1; NM_001131298.1.
DR AlphaFoldDB; Q5REV9; -.
DR STRING; 9601.ENSPPYP00000016368; -.
DR PRIDE; Q5REV9; -.
DR GeneID; 100171622; -.
DR KEGG; pon:100171622; -.
DR CTD; 10568; -.
DR eggNOG; ENOG502QQ3I; Eukaryota.
DR InParanoid; Q5REV9; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0042301; F:phosphate ion binding; ISS:UniProtKB.
DR GO; GO:0031402; F:sodium ion binding; ISS:UniProtKB.
DR GO; GO:0005436; F:sodium:phosphate symporter activity; ISS:UniProtKB.
DR GO; GO:0006817; P:phosphate ion transport; ISS:UniProtKB.
DR GO; GO:0044341; P:sodium-dependent phosphate transport; IEA:InterPro.
DR InterPro; IPR003841; Na/Pi_transpt.
DR InterPro; IPR029852; Na/Pi_transpt_2B.
DR PANTHER; PTHR10010; PTHR10010; 1.
DR PANTHER; PTHR10010:SF23; PTHR10010:SF23; 1.
DR Pfam; PF02690; Na_Pi_cotrans; 2.
DR TIGRFAMs; TIGR01013; 2a58; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..689
FT /note="Sodium-dependent phosphate transport protein 2B"
FT /id="PRO_0000068615"
FT TOPO_DOM 1..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=M1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..135
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=M2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=M3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..362
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical; Name=M4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 384..407
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 408..428
FT /note="Helical; Name=M5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 429..485
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 486..506
FT /note="Helical; Name=M6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 507..525
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 526..546
FT /note="Helical; Name=M7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 547..552
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 553..573
FT /note="Helical; Name=M8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 574..687
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 294
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 307
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 320
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 302..349
FT /evidence="ECO:0000250|UniProtKB:Q06496"
SQ SEQUENCE 689 AA; 75521 MW; EFA4F504E2482B5C CRC64;
MAPWPELGDA QPNPDKYLEG AAGQQPTAPD KSKETNKNNT EAPVTKIELL PTYSTATLID
EPTEVDDPWN IPTLQDSGIK WSERDTKGKI LCVFQGIGRL ILLLGFLYFF VCSLDILSSA
FQLVGGKMAG QFFSNSSIMS NPLLGLVIGV LVTVLVQSSS TSTSIVVSMV SSSLLTVRAA
IPIIMGANIG TSITNTIVAL MQVGDRSEFR RAFAGATVHD FFNWLSVLVL LPVEVATHYL
EIITQLIVDS FHSKNGEDAP DLLKVITKPF TKLIVQLDKK IISQIAMNDE KAKNKSLVKI
WCKTFTNKTQ VNVTVPSTAN CTSPSLCWTD GIQTWTMKNV TYKENIAKCQ HIFVNFHLPD
LAVGTILLIL SLLVLCGCLI MIVKILGSVL KGQVATVIKK TINTDFPFPF AWLTGYLAIL
VGAGMTFIVQ SSSVFTSALT PLIGIGVITI ERAYPLTLGS NIGTTTTAIL AALASPGNAL
RSSLQIALCH FFFNISGILL WYPIPFTRLP IRMAKGLGNI SAKYRWFAVF YLIIFFFLIP
LTVFGLSLAG WRVLVGVGVP VVFIIILVLC LRLLQSRCPR VLPKKLQNWN FLPLWMRSLK
PWDAVFSKFT GCFQMRCCCC CRVCCRACCL LCGCPKCCRC SKCCEDLEEA HEGQDVPVKA
PDTFDNITIS REAQGEVPAS DSKTECTAL
