NPT3_BOVIN
ID NPT3_BOVIN Reviewed; 479 AA.
AC Q32LF0;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Sodium-dependent phosphate transport protein 3;
DE AltName: Full=Na(+)/PI cotransporter 3;
DE AltName: Full=Sodium/phosphate cotransporter 3;
DE AltName: Full=Solute carrier family 17 member 3;
GN Name=SLC17A2; Synonyms=NPT3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Important for the resorption of phosphate by the kidney. May
CC be involved in actively transporting phosphate into cells via Na(+)
CC cotransport in the renal brush border membrane (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PDZK1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC cotransporter family. {ECO:0000305}.
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DR EMBL; BC109616; AAI09617.1; -; mRNA.
DR RefSeq; NP_001033207.1; NM_001038118.1.
DR RefSeq; XP_010816778.1; XM_010818476.2.
DR AlphaFoldDB; Q32LF0; -.
DR SMR; Q32LF0; -.
DR STRING; 9913.ENSBTAP00000003426; -.
DR PaxDb; Q32LF0; -.
DR Ensembl; ENSBTAT00000003426; ENSBTAP00000003426; ENSBTAG00000002642.
DR GeneID; 515523; -.
DR KEGG; bta:515523; -.
DR CTD; 10246; -.
DR VEuPathDB; HostDB:ENSBTAG00000002642; -.
DR VGNC; VGNC:34697; SLC17A2.
DR eggNOG; KOG2532; Eukaryota.
DR GeneTree; ENSGT00940000161926; -.
DR HOGENOM; CLU_001265_5_0_1; -.
DR InParanoid; Q32LF0; -.
DR OMA; FYKHPKD; -.
DR OrthoDB; 497052at2759; -.
DR TreeFam; TF313535; -.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000002642; Expressed in liver and 7 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0015136; F:sialic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006820; P:anion transport; IBA:GO_Central.
DR GO; GO:0015739; P:sialic acid transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium;
KW Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..479
FT /note="Sodium-dependent phosphate transport protein 3"
FT /id="PRO_0000250386"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 274..294
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..373
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 479 AA; 52538 MW; 2DE8D25B52D41752 CRC64;
MDEKPSTRKS PEFCSLRYGL ALIMHFSNFT MITQRVSLSI AIIAMVNRTQ QPGLFNTSTE
RPLAFTFNHS NRSIKEFNTA EVSVYEWSPE TQGIIFSSIN YGIILTLIPS GYLAGIFGAK
QMLGAGLLIS SLLTLFTPLT ADFGVILVIV IRTVQGMAQG MAWTGQFTIW AKWAPPLERS
KLTSIAGSGA AFGSFIILCV GGLISQALGW PFIFYIFGSI GCVCCLLWFT VIYDDPLHHP
CISIREKEHI VSSLAQQSSS PRRSVPIKSM VRCLPLWAIF MGFFSHFWLC TIIITYLPTY
ISSVLHVNIR DSGVLSSLPF IAAASCTILG GQLADFLLSR NLLRLITVRK LFSSLGLLLP
SLCAVALPFV ASSYTTTIIL LILIPGTSNL CDSGFIINTL DVAPRYASFL MGISRGFGLI
AGIISSTATG FLISQDSVSG WRNVFFLAAA VNMFGLVFYL TFGQAEIQHW AKERTLTRL
