NPT3_HUMAN
ID NPT3_HUMAN Reviewed; 439 AA.
AC O00624; A6NK81; A6NLD6; Q5TB84; Q76P85;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Sodium-dependent phosphate transport protein 3;
DE AltName: Full=Na(+)/PI cotransporter 3;
DE AltName: Full=Sodium/phosphate cotransporter 3;
DE AltName: Full=Solute carrier family 17 member 2;
GN Name=SLC17A2; Synonyms=NPT3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2), AND TISSUE
RP SPECIFICITY.
RX PubMed=9149941; DOI=10.1101/gr.7.5.441;
RA Ruddy D.A., Kronmal G.S., Lee V.K., Mintier G.A., Quintana L.,
RA Domingo R. Jr., Meyer N.C., Irrinki A., McClelland E.E., Fullan A.,
RA Mapa F.A., Moore T., Thomas W., Loeb D.B., Harmon C., Tsuchihashi Z.,
RA Wolff R.K., Schatzman R.C., Feder J.N.;
RT "A 1.1-Mb transcript map of the hereditary hemochromatosis locus.";
RL Genome Res. 7:441-456(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in actively transporting phosphate into cells
CC via Na(+) cotransport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=O00624-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O00624-2; Sequence=VSP_020638;
CC Name=3;
CC IsoId=O00624-3; Sequence=VSP_054712;
CC -!- TISSUE SPECIFICITY: Expressed in the small intestine, kidney, spleen
CC and testis. Not detected in fetal brain, bone marrow, and mammary
CC gland. {ECO:0000269|PubMed:9149941}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC cotransporter family. {ECO:0000305}.
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DR EMBL; U91328; AAB82085.1; -; Genomic_DNA.
DR EMBL; U90544; AAB53422.1; -; mRNA.
DR EMBL; AL138726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471087; EAW55498.1; -; Genomic_DNA.
DR EMBL; CH471087; EAW55499.1; -; Genomic_DNA.
DR EMBL; BC104822; AAI04823.1; -; mRNA.
DR EMBL; BC112033; AAI12034.1; -; mRNA.
DR EMBL; BC143323; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS4567.1; -. [O00624-2]
DR CCDS; CCDS69060.1; -. [O00624-3]
DR RefSeq; NP_001273052.1; NM_001286123.1. [O00624-3]
DR RefSeq; NP_001273054.1; NM_001286125.1.
DR RefSeq; NP_005826.1; NM_005835.3. [O00624-2]
DR RefSeq; XP_005248841.1; XM_005248784.2.
DR RefSeq; XP_006715012.1; XM_006714949.3. [O00624-3]
DR AlphaFoldDB; O00624; -.
DR SMR; O00624; -.
DR BioGRID; 115540; 57.
DR IntAct; O00624; 51.
DR STRING; 9606.ENSP00000367081; -.
DR ChEMBL; CHEMBL3769300; -.
DR TCDB; 2.A.1.14.29; the major facilitator superfamily (mfs).
DR GlyGen; O00624; 5 sites, 1 O-linked glycan (1 site).
DR PhosphoSitePlus; O00624; -.
DR BioMuta; SLC17A2; -.
DR jPOST; O00624; -.
DR MassIVE; O00624; -.
DR PaxDb; O00624; -.
DR PeptideAtlas; O00624; -.
DR PRIDE; O00624; -.
DR Antibodypedia; 25472; 94 antibodies from 23 providers.
DR DNASU; 10246; -.
DR Ensembl; ENST00000265425.3; ENSP00000265425.3; ENSG00000112337.11. [O00624-1]
DR Ensembl; ENST00000360488.7; ENSP00000353677.3; ENSG00000112337.11. [O00624-2]
DR Ensembl; ENST00000377850.8; ENSP00000367081.3; ENSG00000112337.11. [O00624-3]
DR GeneID; 10246; -.
DR KEGG; hsa:10246; -.
DR MANE-Select; ENST00000377850.8; ENSP00000367081.3; NM_001286123.3; NP_001273052.1. [O00624-3]
DR UCSC; uc003nfl.5; human. [O00624-1]
DR CTD; 10246; -.
DR DisGeNET; 10246; -.
DR GeneCards; SLC17A2; -.
DR HGNC; HGNC:10930; SLC17A2.
DR HPA; ENSG00000112337; Tissue enriched (liver).
DR MIM; 611049; gene.
DR neXtProt; NX_O00624; -.
DR OpenTargets; ENSG00000112337; -.
DR PharmGKB; PA35821; -.
DR VEuPathDB; HostDB:ENSG00000112337; -.
DR eggNOG; KOG2532; Eukaryota.
DR GeneTree; ENSGT00940000161926; -.
DR HOGENOM; CLU_001265_5_0_1; -.
DR InParanoid; O00624; -.
DR OMA; FYKHPKD; -.
DR OrthoDB; 497052at2759; -.
DR PhylomeDB; O00624; -.
DR TreeFam; TF313535; -.
DR PathwayCommons; O00624; -.
DR SignaLink; O00624; -.
DR BioGRID-ORCS; 10246; 7 hits in 1053 CRISPR screens.
DR GenomeRNAi; 10246; -.
DR Pharos; O00624; Tdark.
DR PRO; PR:O00624; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; O00624; protein.
DR Bgee; ENSG00000112337; Expressed in right lobe of liver and 21 other tissues.
DR ExpressionAtlas; O00624; baseline and differential.
DR Genevisible; O00624; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0015136; F:sialic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005436; F:sodium:phosphate symporter activity; TAS:ProtInc.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006820; P:anion transport; IBA:GO_Central.
DR GO; GO:0006796; P:phosphate-containing compound metabolic process; TAS:ProtInc.
DR GO; GO:0015739; P:sialic acid transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; TAS:ProtInc.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..439
FT /note="Sodium-dependent phosphate transport protein 3"
FT /id="PRO_0000220940"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 350..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 355..439
FT /note="GLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYA
FT SFLMGISRGFGLIAGIISSTATGFLISQVGPVY -> DMQVSSWESQGDLGSSQESSLP
FT LPLDSSSVRILSLVGGMSFSCLLQSTCLAWSFTSRLDKQNFKTGPKRGPLPASEDIKLQ
FT T (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:9149941"
FT /id="VSP_020638"
FT VAR_SEQ 435..439
FT /note="VGPVY -> DFESGWRNVFFLSAAVNMFGLVFYLTFGQAELQDWAKERTLTR
FT L (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_054712"
SQ SEQUENCE 439 AA; 47277 MW; 67494C6E00EABB54 CRC64;
MDGKPATRKG PDFCSLRYGL ALIMHFSNFT MITQRVSLSI AIIAMVNTTQ QQGLSNASTE
GPVADAFNNS SISIKEFDTK ASVYQWSPET QGIIFSSINY GIILTLIPSG YLAGIFGAKK
MLGAGLLISS LLTLFTPLAA DFGVILVIMV RTVQGMAQGM AWTGQFTIWA KWAPPLERSK
LTTIAGSGSA FGSFIILCVG GLISQALSWP FIFYIFGSTG CVCCLLWFTV IYDDPMHHPC
ISVREKEHIL SSLAQQPSSP GRAVPIKAMV TCLPLWAIFL GFFSHFWLCT IILTYLPTYI
STLLHVNIRD SGVLSSLPFI AAASCTILGG QLADFLLSRN LLRLITVRKL FSSLGLLLPS
ICAVALPFVA SSYVITIILL ILIPGTSNLC DSGFIINTLD IAPRYASFLM GISRGFGLIA
GIISSTATGF LISQVGPVY
