NPT3_MOUSE
ID NPT3_MOUSE Reviewed; 478 AA.
AC Q5SZA1; Q8VCX8;
DT 19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Sodium-dependent phosphate transport protein 3;
DE AltName: Full=Na(+)/PI cotransporter 3;
DE AltName: Full=Sodium/phosphate cotransporter 3;
DE AltName: Full=Solute carrier family 17 member 2;
GN Name=Slc17a2; Synonyms=Npt3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Important for the resorption of phosphate by the kidney. May
CC be involved in actively transporting phosphate into cells via Na(+)
CC cotransport in the renal brush border membrane (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PDZK1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5SZA1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SZA1-2; Sequence=VSP_020639;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sodium/anion
CC cotransporter family. {ECO:0000305}.
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DR EMBL; AL590388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC018306; AAH18306.1; -; mRNA.
DR CCDS; CCDS36620.1; -. [Q5SZA1-2]
DR RefSeq; NP_659085.1; NM_144836.2. [Q5SZA1-2]
DR RefSeq; XP_006516711.1; XM_006516648.3. [Q5SZA1-1]
DR RefSeq; XP_006516715.1; XM_006516652.2. [Q5SZA1-2]
DR AlphaFoldDB; Q5SZA1; -.
DR SMR; Q5SZA1; -.
DR STRING; 10090.ENSMUSP00000006786; -.
DR GlyGen; Q5SZA1; 4 sites.
DR iPTMnet; Q5SZA1; -.
DR PhosphoSitePlus; Q5SZA1; -.
DR jPOST; Q5SZA1; -.
DR MaxQB; Q5SZA1; -.
DR PaxDb; Q5SZA1; -.
DR PeptideAtlas; Q5SZA1; -.
DR PRIDE; Q5SZA1; -.
DR ProteomicsDB; 253097; -. [Q5SZA1-1]
DR ProteomicsDB; 253098; -. [Q5SZA1-2]
DR Antibodypedia; 25472; 94 antibodies from 23 providers.
DR DNASU; 218103; -.
DR Ensembl; ENSMUST00000006786; ENSMUSP00000006786; ENSMUSG00000036110. [Q5SZA1-2]
DR Ensembl; ENSMUST00000099697; ENSMUSP00000097288; ENSMUSG00000036110. [Q5SZA1-1]
DR GeneID; 218103; -.
DR KEGG; mmu:218103; -.
DR UCSC; uc007pvb.1; mouse. [Q5SZA1-2]
DR CTD; 10246; -.
DR MGI; MGI:2443098; Slc17a2.
DR VEuPathDB; HostDB:ENSMUSG00000036110; -.
DR eggNOG; KOG2532; Eukaryota.
DR GeneTree; ENSGT00940000161926; -.
DR HOGENOM; CLU_001265_5_0_1; -.
DR InParanoid; Q5SZA1; -.
DR OMA; FYKHPKD; -.
DR OrthoDB; 497052at2759; -.
DR PhylomeDB; Q5SZA1; -.
DR TreeFam; TF313535; -.
DR BioGRID-ORCS; 218103; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Slc17a2; mouse.
DR PRO; PR:Q5SZA1; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q5SZA1; protein.
DR Bgee; ENSMUSG00000036110; Expressed in left lobe of liver and 28 other tissues.
DR Genevisible; Q5SZA1; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0015136; F:sialic acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006820; P:anion transport; IBA:GO_Central.
DR GO; GO:0015739; P:sialic acid transport; IBA:GO_Central.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..478
FT /note="Sodium-dependent phosphate transport protein 3"
FT /id="PRO_0000250387"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 56
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 435..478
FT /note="DSESGWRNVFFLSAAVNMFGLIFYLIFGQAEIQSWAKERTLTRL -> VGHV
FT IEHLQVAGF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020639"
SQ SEQUENCE 478 AA; 51965 MW; 3E889F0691509CBD CRC64;
MDEKPTTRKG SGFCSLRYAL ALIMHFSNFT MITQRVSLSI AIIAMVNSTQ HQDPANASTE
GPVMDLLSNQ SRGIKDFSTR AAVYQWSTET QGIIFSSISY GIILTLIPSG YLAGIFGAKQ
ILGAGLLISS LLTLFTPLAA DFGVILVIVI RTVQGMAQGM AWTGQFTIWA KWAPPLERSK
LTSIAGSGAA FGSFIILCVG GLISQALGWP FIFYIFGSIG CVCCVLWFTV IYDDPMHHPC
ISVREKEHIT SSVAQQSSSP RRSVPIKAMV RCLPLWAIFM GFFSHFWLCT IIITYLPTYI
STVLHVNIRD SGVLSSLPFI AASSCTILGG QMADFLLSRN LLSLITVRKL FSSLGLLLPS
LCAVALPFVT SSYIATIVLL ILIPGTSNLC DSGFIINTLD VAPRYASFLM GISRGFGLTA
GIISSTTTGF LISQDSESGW RNVFFLSAAV NMFGLIFYLI FGQAEIQSWA KERTLTRL
