NPTX1_MOUSE
ID NPTX1_MOUSE Reviewed; 432 AA.
AC Q62443;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Neuronal pentraxin-1;
DE Short=NP1;
DE AltName: Full=Neuronal pentraxin I;
DE Short=NP-I;
DE Flags: Precursor;
GN Name=Nptx1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8884281; DOI=10.1006/geno.1996.0503;
RA Omeis I.A., Hsu Y.-C., Perin M.S.;
RT "Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic
RT structure, and chromosomal localization.";
RL Genomics 36:543-545(1996).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in mediating uptake of synaptic material
CC during synapse remodeling or in mediating the synaptic clustering of
CC AMPA glutamate receptors at a subset of excitatory synapses.
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC Note=Binds 2 calcium ions per subunit. {ECO:0000250};
CC -!- SUBUNIT: Homooligomer or heterooligomer (probably pentamer) with
CC neuronal pentraxin receptor (NPTXR). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle
CC {ECO:0000305}.
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DR EMBL; U62021; AAC52826.1; -; Genomic_DNA.
DR CCDS; CCDS25719.1; -.
DR RefSeq; NP_032756.1; NM_008730.2.
DR AlphaFoldDB; Q62443; -.
DR SMR; Q62443; -.
DR BioGRID; 201833; 4.
DR IntAct; Q62443; 2.
DR MINT; Q62443; -.
DR STRING; 10090.ENSMUSP00000026670; -.
DR GlyConnect; 2552; 11 N-Linked glycans (2 sites).
DR GlyGen; Q62443; 2 sites, 11 N-linked glycans (2 sites).
DR PhosphoSitePlus; Q62443; -.
DR MaxQB; Q62443; -.
DR PaxDb; Q62443; -.
DR PRIDE; Q62443; -.
DR ProteomicsDB; 293882; -.
DR Antibodypedia; 32766; 411 antibodies from 32 providers.
DR DNASU; 18164; -.
DR Ensembl; ENSMUST00000026670; ENSMUSP00000026670; ENSMUSG00000025582.
DR GeneID; 18164; -.
DR KEGG; mmu:18164; -.
DR UCSC; uc007mqv.1; mouse.
DR CTD; 4884; -.
DR MGI; MGI:107811; Nptx1.
DR VEuPathDB; HostDB:ENSMUSG00000025582; -.
DR eggNOG; ENOG502QTID; Eukaryota.
DR GeneTree; ENSGT01050000244805; -.
DR HOGENOM; CLU_032051_0_0_1; -.
DR InParanoid; Q62443; -.
DR OMA; AQNFGQT; -.
DR OrthoDB; 770812at2759; -.
DR PhylomeDB; Q62443; -.
DR TreeFam; TF330208; -.
DR BioGRID-ORCS; 18164; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q62443; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q62443; protein.
DR Bgee; ENSMUSG00000025582; Expressed in cerebellum lobe and 142 other tissues.
DR ExpressionAtlas; Q62443; baseline and differential.
DR Genevisible; Q62443; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0098978; C:glutamatergic synapse; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0043083; C:synaptic cleft; ISO:MGI.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0060385; P:axonogenesis involved in innervation; IGI:MGI.
DR GO; GO:0071333; P:cellular response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0035865; P:cellular response to potassium ion; ISO:MGI.
DR GO; GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; ISO:MGI.
DR GO; GO:0006839; P:mitochondrial transport; ISO:MGI.
DR GO; GO:0099645; P:neurotransmitter receptor localization to postsynaptic specialization membrane; ISO:MGI.
DR GO; GO:0099151; P:regulation of postsynaptic density assembly; ISO:MGI.
DR GO; GO:0098962; P:regulation of postsynaptic neurotransmitter receptor activity; ISO:MGI.
DR CDD; cd00152; PTX; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR030476; Pentaxin_CS.
DR InterPro; IPR001759; Pentraxin-related.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS00289; PTX_1; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 1: Evidence at protein level;
KW Calcium; Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Metal-binding;
KW Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..432
FT /note="Neuronal pentraxin-1"
FT /id="PRO_0000023548"
FT DOMAIN 226..428
FT /note="Pentraxin (PTX)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT REGION 88..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 280
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 358
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 358
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 359
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 360
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 360
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 370
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT CARBOHYD 154
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 193
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 256..316
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
SQ SEQUENCE 432 AA; 47117 MW; 0698B8BAE4948923 CRC64;
MLAGRAARTC ALLALCLLGS GAQDFGPTRF ICTSVPVDAD MCAASVAAGG AEELRSNVLQ
LRETVLQQKE TILSQKETIR ELTTKLGRCE SQSTLDSGPG EARSGGGRKQ PGSGKNTMGD
LSRTPAAETL SQLGQTLQSL KTRLENLEQY SRLNSSSQTN SLKDLLQSKI DDLERQVLSR
VNTLEEGKGG PKNDTEERAK IESALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY
AKVKKSLPEM YAFTVCMWLK SSAAPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGNGEN LAPYHPIKPQ GVLVLGQEQD
TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSSK ALSGNVIAWA ESQIEIFGGA
TKWTFEACRQ IN